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mvb12bb multivesicular body subunit 12Bb [ Danio rerio (zebrafish) ]

Gene ID: 100004330, updated on 2-Nov-2024

Summary

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Official Symbol
mvb12bbprovided by ZNC
Official Full Name
multivesicular body subunit 12Bbprovided by ZNC
Primary source
ZFIN:ZDB-GENE-080414-2
See related
Ensembl:ENSDARG00000079478 AllianceGenome:ZFIN:ZDB-GENE-080414-2
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fam125bb
Summary
Predicted to be involved in regulation of epidermal growth factor receptor signaling pathway; viral budding; and virus maturation. Predicted to act upstream of or within protein transport. Predicted to be located in late endosome membrane. Predicted to be part of ESCRT I complex. Predicted to be active in late endosome. Orthologous to human MVB12B (multivesicular body subunit 12B). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See mvb12bb in Genome Data Viewer
Location:
chromosome: 8
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (33420677..33568965, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (33411445..33559728, complement)

Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene LIM homeobox transcription factor 1, beta b Neighboring gene uncharacterized LOC110440017 Neighboring gene uncharacterized LOC137496300 Neighboring gene uncharacterized LOC137496366 Neighboring gene uncharacterized LOC101882658 Neighboring gene pre-B-cell leukemia homeobox 3b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. A long noncoding RNA cluster-based genomic locus maintains proper development and visual function. Wang F, et al. Nucleic Acids Res, 2019 Jul 9. PMID 31127312, Free PMC Article
  2. Contrasted innate responses to two viruses in zebrafish: insights into the ancestral repertoire of vertebrate IFN-stimulated genes. Briolat V, et al. J Immunol, 2014 May 1. PMID 24683187
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Process Evidence Code Pubs
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of epidermal growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in viral budding IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in virus maturation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of ESCRT I complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ESCRT I complex IEA
Inferred from Electronic Annotation
more info
  
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in late endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in late endosome membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
multivesicular body subunit 12Bb
Names
fam125b
family with sequence similarity 125, member B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001136477.1 → NP_001129949.1  multivesicular body subunit 12Bb

    Status: VALIDATED

    Source sequence(s)
    BM182452, BM182806, EB876116
    UniProtKB/TrEMBL
    A0A8M1NIX6
    Related
    ENSDARP00000116123.1, ENSDART00000138921.2
    Conserved Domains (1) summary
    pfam10240
    Location:19 → 263
    DUF2464; Protein of unknown function (DUF2464)

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007119.7 Reference GRCz11 Primary Assembly

    Range
    33420677..33568965 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021478155.2 → XP_021333830.1  multivesicular body subunit 12Bb isoform X1

    UniProtKB/TrEMBL
    A0A8M9QID7
    Conserved Domains (1) summary
    pfam10240
    Location:19 → 263
    DUF2464; Multivesicular body subunit 12
Nucleotide Protein Strain
Heading Accession and Version

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