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otulinb OTU deubiquitinase with linear linkage specificity b [ Danio rerio (zebrafish) ]

Gene ID: 100005714, updated on 17-Aug-2024

Summary

Official Symbol
otulinbprovided by ZNC
Official Full Name
OTU deubiquitinase with linear linkage specificity bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-070912-627
See related
Ensembl:ENSDARG00000079886 AllianceGenome:ZFIN:ZDB-GENE-070912-627
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fam105bb; wu:fc69a03; si:dkeyp-106c5.3
Summary
Predicted to enable thiol-dependent deubiquitinase. Predicted to be involved in protein linear deubiquitination. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in otulipenia. Orthologous to several human genes including OTULIN (OTU deubiquitinase with linear linkage specificity). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

Location:
chromosome: 2
Exon count:
10
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (31942377..31952001)
105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (31959157..31969085)

Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene Ig kappa chain V-III region PC 2485/PC 4039-like Neighboring gene amphiphysin Neighboring gene ANKH inorganic pyrophosphate transport regulator b Neighboring gene MYC proto-oncogene, bHLH transcription factor b

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

General gene information

Markers

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables cysteine-type deubiquitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in protein linear deubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
OTU deubiquitinase with linear linkage specificity b
Names
family with sequence similarity 105, member B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001166015.1NP_001159487.1  OTU deubiquitinase with linear linkage specificity b

    See identical proteins and their annotated locations for NP_001159487.1

    Status: PROVISIONAL

    Source sequence(s)
    CR391940
    UniProtKB/TrEMBL
    A0A8M2BAN8, B0UY67
    Related
    ENSDARP00000113277.1, ENSDART00000146758.3
    Conserved Domains (1) summary
    pfam16218
    Location:121380
    Peptidase_C101; Peptidase family C101

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007113.7 Reference GRCz11 Primary Assembly

    Range
    31942377..31952001
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005163466.4XP_005163523.1  OTU deubiquitinase with linear linkage specificity b isoform X1

    See identical proteins and their annotated locations for XP_005163523.1

    UniProtKB/TrEMBL
    A0A8M2BAN8, B0UY67
    Conserved Domains (1) summary
    pfam16218
    Location:121380
    Peptidase_C101; Peptidase family C101
  2. XM_009298596.3XP_009296871.1  OTU deubiquitinase with linear linkage specificity b isoform X2

    See identical proteins and their annotated locations for XP_009296871.1

    UniProtKB/TrEMBL
    A0A8M3B0B6
    Conserved Domains (1) summary
    pfam16218
    Location:61320
    Peptidase_C101; Peptidase family C101
  3. XM_005163471.3XP_005163528.1  OTU deubiquitinase with linear linkage specificity b isoform X2

    See identical proteins and their annotated locations for XP_005163528.1

    UniProtKB/TrEMBL
    A0A8M3B0B6
    Related
    ENSDART00000133182.3
    Conserved Domains (1) summary
    pfam16218
    Location:61320
    Peptidase_C101; Peptidase family C101
  4. XM_005163469.3XP_005163526.1  OTU deubiquitinase with linear linkage specificity b isoform X2

    See identical proteins and their annotated locations for XP_005163526.1

    UniProtKB/TrEMBL
    A0A8M3B0B6
    Related
    ENSDART00000132113.3
    Conserved Domains (1) summary
    pfam16218
    Location:61320
    Peptidase_C101; Peptidase family C101
  5. XM_005163467.4XP_005163524.1  OTU deubiquitinase with linear linkage specificity b isoform X1

    See identical proteins and their annotated locations for XP_005163524.1

    UniProtKB/TrEMBL
    A0A8M2BAN8, B0UY67
    Conserved Domains (1) summary
    pfam16218
    Location:121380
    Peptidase_C101; Peptidase family C101
  6. XM_005163470.4XP_005163527.1  OTU deubiquitinase with linear linkage specificity b isoform X2

    See identical proteins and their annotated locations for XP_005163527.1

    UniProtKB/TrEMBL
    A0A8M3B0B6
    Conserved Domains (1) summary
    pfam16218
    Location:61320
    Peptidase_C101; Peptidase family C101
  7. XM_005163468.4XP_005163525.1  OTU deubiquitinase with linear linkage specificity b isoform X1

    See identical proteins and their annotated locations for XP_005163525.1

    UniProtKB/TrEMBL
    A0A8M2BAN8, B0UY67
    Conserved Domains (1) summary
    pfam16218
    Location:121380
    Peptidase_C101; Peptidase family C101