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tle3b TLE family member 3, transcriptional corepressor b [ Danio rerio (zebrafish) ]

Gene ID: 100007463, updated on 28-Oct-2024

Summary

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Official Symbol
tle3bprovided by ZNC
Official Full Name
TLE family member 3, transcriptional corepressor bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-990415-85
See related
Ensembl:ENSDARG00000069006 AllianceGenome:ZFIN:ZDB-GENE-990415-85
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
grg3; gro1; gro3; GROUCHO1; wu:fi28a02; wu:fj62f10
Summary
Predicted to enable transcription corepressor activity. Acts upstream of or within myeloid cell differentiation. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Is expressed in several structures, including axis; head; mesoderm; pleuroperitoneal region; and unfertilized egg. Orthologous to human TLE3 (TLE family member 3, transcriptional corepressor). [provided by Alliance of Genome Resources, Oct 2024]
Orthologs
all
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Genomic context

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See tle3b in Genome Data Viewer
Location:
chromosome: 7
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (33645659..33684691, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (33374862..33413580, complement)

Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene progestin and adipoQ receptor family member Vb Neighboring gene uncharacterized LOC137496098 Neighboring gene uveal autoantigen with coiled-coil domains and ankyrin repeats b Neighboring gene relaxin family peptide receptor 3.3a1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. The homeobox protein Six3 interacts with the Groucho corepressor and acts as a transcriptional repressor in eye and forebrain formation. Kobayashi M, et al. Dev Biol, 2001 Apr 15. PMID 11401394
  2. Two zebrafish homologues of the Drosophila neurogenic gene groucho and their pattern of transcription during early embryogenesis. Wülbeck C, et al. Dev Genes Evol, 1997 Aug. PMID 27747413
  3. Evolution of the Groucho/Tle gene family: gene organization and duplication events. Bajoghli B. Dev Genes Evol, 2007 Aug. PMID 17624551
  4. Balancing cell numbers during organogenesis: Six1a differentially affects neurons and sensory hair cells in the inner ear. Bricaud O, et al. Dev Biol, 2011 Sep 1. PMID 21745464, Free PMC Article
  5. Isolation of nlz2 and characterization of essential domains in Nlz family proteins. Runko AP, et al. J Biol Chem, 2004 Mar 19. PMID 14709556

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within myeloid cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of transcription regulator complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
transducin-like enhancer protein 3-B
Names
groucho 1
protein groucho-1
transducin-like enhancer of split 3b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_131780.1 → NP_571855.1  transducin-like enhancer protein 3-B

    See identical proteins and their annotated locations for NP_571855.1

    Status: PROVISIONAL

    Source sequence(s)
    AB040707
    UniProtKB/Swiss-Prot
    O13166, O13168, Q98TH2
    Related
    ENSDARP00000143498.1, ENSDART00000175980.2
    Conserved Domains (4) summary
    cd00200
    Location:483 → 768
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam07271
    Location:147 → 431
    Cytadhesin_P30; Cytadhesin P30/P32
    sd00039
    Location:488 → 527
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:1 → 143
    TLE_N; Groucho/TLE N-terminal Q-rich domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007118.7 Reference GRCz11 Primary Assembly

    Range
    33645659..33684691 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068222129.1 → XP_068078230.1  transducin-like enhancer protein 3-B isoform X13

  2. XM_005168834.5 → XP_005168891.1  transducin-like enhancer protein 3-B isoform X10

    See identical proteins and their annotated locations for XP_005168891.1

    UniProtKB/Swiss-Prot
    O13166
    UniProtKB/TrEMBL
    A0A8M2BG40
    Conserved Domains (5) summary
    COG2319
    Location:476 → 768
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:482 → 767
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam03920
    Location:1 → 142
    TLE_N; Groucho/TLE N-terminal Q-rich domain
    pfam07271
    Location:146 → 430
    Cytadhesin_P30; Cytadhesin P30/P32
    sd00039
    Location:487 → 526
    7WD40; WD40 repeat [structural motif]

  3. XM_068222128.1 → XP_068078229.1  transducin-like enhancer protein 3-B isoform X12

  4. XM_068222123.1 → XP_068078224.1  transducin-like enhancer protein 3-B isoform X7

    Related
    ENSDARP00000109120.2, ENSDART00000130553.4

  5. XM_009303191.4 → XP_009301466.1  transducin-like enhancer protein 3-B isoform X1

    See identical proteins and their annotated locations for XP_009301466.1

    UniProtKB/Swiss-Prot
    O13166
    UniProtKB/TrEMBL
    A0A8M3AU69
    Conserved Domains (5) summary
    COG2319
    Location:488 → 780
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:494 → 779
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam03920
    Location:1 → 124
    TLE_N; Groucho/TLE N-terminal Q-rich domain
    pfam07271
    Location:158 → 442
    Cytadhesin_P30; Cytadhesin P30/P32
    sd00039
    Location:499 → 538
    7WD40; WD40 repeat [structural motif]

  6. XM_068222124.1 → XP_068078225.1  transducin-like enhancer protein 3-B isoform X7

  7. XM_009303204.4 → XP_009301479.1  transducin-like enhancer protein 3-B isoform X16

    UniProtKB/Swiss-Prot
    O13166
    UniProtKB/TrEMBL
    A0A8M3B175
    Conserved Domains (6) summary
    PHA03249
    Location:252 → 388
    PHA03249; DNA packaging tegument protein UL25; Provisional
    COG2319
    Location:465 → 757
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:471 → 756
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam03920
    Location:1 → 132
    TLE_N; Groucho/TLE N-terminal Q-rich domain
    pfam07271
    Location:136 → 419
    Cytadhesin_P30; Cytadhesin P30/P32
    sd00039
    Location:476 → 515
    7WD40; WD40 repeat [structural motif]

  8. XM_009303202.4 → XP_009301477.1  transducin-like enhancer protein 3-B isoform X14

    UniProtKB/Swiss-Prot
    O13166
    UniProtKB/TrEMBL
    A0A8M3AU78
    Conserved Domains (5) summary
    COG2319
    Location:466 → 758
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:472 → 757
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam03920
    Location:1 → 132
    TLE_N; Groucho/TLE N-terminal Q-rich domain
    pfam07271
    Location:136 → 420
    Cytadhesin_P30; Cytadhesin P30/P32
    sd00039
    Location:477 → 516
    7WD40; WD40 repeat [structural motif]

  9. XM_009303203.4 → XP_009301478.1  transducin-like enhancer protein 3-B isoform X15

    UniProtKB/Swiss-Prot
    O13166
    UniProtKB/TrEMBL
    A0A8M3B444
    Conserved Domains (6) summary
    PHA03249
    Location:253 → 389
    PHA03249; DNA packaging tegument protein UL25; Provisional
    COG2319
    Location:466 → 758
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:472 → 757
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam03920
    Location:1 → 133
    TLE_N; Groucho/TLE N-terminal Q-rich domain
    pfam07271
    Location:137 → 420
    Cytadhesin_P30; Cytadhesin P30/P32
    sd00039
    Location:477 → 516
    7WD40; WD40 repeat [structural motif]

  10. XM_068222126.1 → XP_068078227.1  transducin-like enhancer protein 3-B isoform X11

  11. XM_009303198.4 → XP_009301473.1  transducin-like enhancer protein 3-B isoform X8

    UniProtKB/TrEMBL
    A0A8M3B441
    Conserved Domains (5) summary
    COG2319
    Location:477 → 769
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:483 → 768
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam03920
    Location:1 → 126
    TLE_N; Groucho/TLE N-terminal Q-rich domain
    pfam07271
    Location:147 → 431
    Cytadhesin_P30; Cytadhesin P30/P32
    sd00039
    Location:488 → 527
    7WD40; WD40 repeat [structural motif]

  12. XM_068222125.1 → XP_068078226.1  transducin-like enhancer protein 3-B isoform X9

  13. XM_068222122.1 → XP_068078223.1  transducin-like enhancer protein 3-B isoform X6

  14. XM_009303196.4 → XP_009301471.1  transducin-like enhancer protein 3-B isoform X5

    UniProtKB/Swiss-Prot
    O13166
    UniProtKB/TrEMBL
    A0A8M3AU75
    Conserved Domains (5) summary
    COG2319
    Location:486 → 778
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:492 → 777
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam03920
    Location:1 → 152
    TLE_N; Groucho/TLE N-terminal Q-rich domain
    pfam07271
    Location:156 → 440
    Cytadhesin_P30; Cytadhesin P30/P32
    sd00039
    Location:497 → 536
    7WD40; WD40 repeat [structural motif]

  15. XM_009303193.4 → XP_009301468.1  transducin-like enhancer protein 3-B isoform X2

    UniProtKB/Swiss-Prot
    O13166
    UniProtKB/TrEMBL
    A0A8M3B166
    Conserved Domains (5) summary
    COG2319
    Location:487 → 779
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:493 → 778
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam03920
    Location:1 → 124
    TLE_N; Groucho/TLE N-terminal Q-rich domain
    pfam07271
    Location:157 → 441
    Cytadhesin_P30; Cytadhesin P30/P32
    sd00039
    Location:498 → 537
    7WD40; WD40 repeat [structural motif]

  16. XM_009303194.4 → XP_009301469.1  transducin-like enhancer protein 3-B isoform X3

    UniProtKB/Swiss-Prot
    O13166
    UniProtKB/TrEMBL
    A0A8M3AU81
    Conserved Domains (5) summary
    COG2319
    Location:487 → 779
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:493 → 778
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam03920
    Location:1 → 153
    TLE_N; Groucho/TLE N-terminal Q-rich domain
    pfam07271
    Location:157 → 441
    Cytadhesin_P30; Cytadhesin P30/P32
    sd00039
    Location:498 → 537
    7WD40; WD40 repeat [structural motif]

  17. XM_009303195.4 → XP_009301470.1  transducin-like enhancer protein 3-B isoform X4

    UniProtKB/Swiss-Prot
    O13166
    UniProtKB/TrEMBL
    A0A8M3BB02
    Conserved Domains (5) summary
    PHA03249
    Location:274 → 410
    PHA03249; DNA packaging tegument protein UL25; Provisional
    COG2319
    Location:487 → 779
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:493 → 778
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam03920
    Location:1 → 124
    TLE_N; Groucho/TLE N-terminal Q-rich domain
    sd00039
    Location:498 → 537
    7WD40; WD40 repeat [structural motif]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O13168.2 GenPept UniProtKB/Swiss-Prot:O13168

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