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myhz1.3 myosin, heavy polypeptide 1.3, skeletal muscle [ Danio rerio (zebrafish) ]

Gene ID: 100008070, updated on 28-Oct-2024

Summary

Official Symbol
myhz1.3provided by ZNC
Official Full Name
myosin, heavy polypeptide 1.3, skeletal muscleprovided by ZNC
Primary source
ZFIN:ZDB-GENE-070705-74
See related
Ensembl:ENSDARG00000067997 AllianceGenome:ZFIN:ZDB-GENE-070705-74
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
myhz1; fmyhcx; fmyhc1.3; ns:zf-e68; si:ch211-158m24.9
Summary
Predicted to enable actin filament binding activity and microfilament motor activity. Predicted to be involved in muscle contraction. Predicted to be part of myosin II complex. Predicted to be active in cytoplasm and myosin filament. Is expressed in adaxial cell; fast muscle cell; and trunk. Human ortholog(s) of this gene implicated in arthrogryposis multiplex congenita; contractures, pterygia, and spondylocarpotarsal fusion syndrome (multiple); disease of cellular proliferation; and distal arthrogryposis (multiple). Orthologous to several human genes including MYH1 (myosin heavy chain 1); MYH4 (myosin heavy chain 4); and MYH8 (myosin heavy chain 8). [provided by Alliance of Genome Resources, Oct 2024]
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Genomic context

See myhz1.3 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
41
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (32262499..32274382, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (31662346..31674233, complement)

Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene myosin heavy chain 4 Neighboring gene myosin, heavy chain a Neighboring gene myosin, heavy polypeptide 1.2, skeletal muscle Neighboring gene myosin, heavy polypeptide 1.1, skeletal muscle

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

General gene information

Markers

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables actin binding IEA
Inferred from Electronic Annotation
more info
 
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables actin filament binding IEA
Inferred from Electronic Annotation
more info
 
enables cytoskeletal motor activity IEA
Inferred from Electronic Annotation
more info
 
enables microfilament motor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in muscle contraction IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in system development IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of myosin II complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of myosin complex IEA
Inferred from Electronic Annotation
more info
 
is_active_in myosin filament IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
myosin heavy chain, fast skeletal muscle
Names
fast skeletal muscle myosin heavy polypeptide 1
myosin, heavy polypeptide 2, fast muscle

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007116.7 Reference GRCz11 Primary Assembly

    Range
    32262499..32274382 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_001923979.8XP_001924014.2  myosin heavy chain, fast skeletal muscle

    UniProtKB/TrEMBL
    A0A8M1QRD9, B8A569, E7F1Z4
    Related
    ENSDARP00000111326.2, ENSDART00000122889.3
    Conserved Domains (7) summary
    cd01377
    Location:101768
    MYSc_class_II; class II myosins, motor domain
    pfam00063
    Location:89768
    Myosin_head; Myosin head (motor domain)
    pfam01576
    Location:8821925
    Myosin_tail_1; Myosin tail
    pfam02736
    Location:3674
    Myosin_N; Myosin N-terminal SH3-like domain
    pfam07851
    Location:14731583
    TMPIT; TMPIT-like protein
    cl00459
    Location:12971409
    MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily
    cl02488
    Location:8811043
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...