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zgc:171426 zgc:171426 [ Danio rerio (zebrafish) ]

Gene ID: 100137103, updated on 2-Nov-2024

Summary

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Official Symbol
zgc:171426provided by ZNC
Official Full Name
zgc:171426provided by ZNC
Primary source
ZFIN:ZDB-GENE-080212-2
See related
AllianceGenome:ZFIN:ZDB-GENE-080212-2
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in nervous system development. Predicted to act upstream of or within negative regulation of peptidase activity. Predicted to be located in extracellular space. Human ortholog(s) of this gene implicated in otitis media. Orthologous to human A2ML1 (alpha-2-macroglobulin like 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See zgc:171426 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
34
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (3469597..3481763)
105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (3687360..3699511)

Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene si:dkey-46g23.5 Neighboring gene zgc:165453 Neighboring gene zmp:0000000896 Neighboring gene CDC42 effector protein (Rho GTPase binding) 1b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
enables peptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
enables serine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
acts_upstream_of_or_within negative regulation of peptidase activity IEA
Inferred from Electronic Annotation
more info
  
involved_in nervous system development IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
pregnancy zone protein; uncharacterized protein LOC100137103

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007114.7 Reference GRCz11 Primary Assembly

    Range
    3469597..3481763
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017354907.3 → XP_017210396.1  pregnancy zone protein

    UniProtKB/TrEMBL
    A0A8M6YXV1
    Conserved Domains (7) summary
    COG2373
    Location:148 → 1086
    YfaS; Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function prediction only]
    cd02897
    Location:977 → 1252
    A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
    pfam00207
    Location:759 → 847
    A2M; Alpha-2-macroglobulin family
    pfam01835
    Location:147 → 239
    A2M_N; MG2 domain
    pfam07677
    Location:1372 → 1461
    A2M_recep; A-macroglobulin receptor
    pfam07678
    Location:1029 → 1252
    A2M_comp; A-macroglobulin complement component
    pfam07703
    Location:484 → 628
    A2M_N_2; Alpha-2-macroglobulin family N-terminal region

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001114700.1: Suppressed sequence

    Description
    NM_001114700.1: This RefSeq was suppressed temporarily based on the calculation that the encoded protein was shorter than proteins from the putative ortholog from cow: A2M (GeneID:513856).
Nucleotide Protein Strain
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