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apoda.2 apolipoprotein Da, duplicate 2 [ Danio rerio (zebrafish) ]

Gene ID: 100148022, updated on 2-Nov-2024

Summary

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Official Symbol
apoda.2provided by ZNC
Official Full Name
apolipoprotein Da, duplicate 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-070912-551
See related
Ensembl:ENSDARG00000060350 AllianceGenome:ZFIN:ZDB-GENE-070912-551
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
si:dkey-52k20.7
Summary
Predicted to enable lipid binding activity. Predicted to be involved in lipid metabolic process and response to reactive oxygen species. Predicted to act upstream of or within brain development; lipid transport; and tissue regeneration. Predicted to be located in extracellular region. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in obesity and type 2 diabetes mellitus. Orthologous to human APOD (apolipoprotein D). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See apoda.2 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (37207462..37215987)
105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (37225005..37233530)

Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene peroxisomal biogenesis factor 19 Neighboring gene COPI coat complex subunit alpha Neighboring gene apolipoprotein Da, duplicate 1 Neighboring gene sterile alpha motif domain containing 7 Neighboring gene SEC62 homolog, preprotein translocation factor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Pathway-specific protein domains are predictive for human diseases. Shim JE, et al. PLoS Comput Biol, 2019 May. PMID 31075101, Free PMC Article
  2. Transcriptional signature of accessory cells in the lateral line, using the Tnk1bp1:EGFP transgenic zebrafish line. Behra M, et al. BMC Dev Biol, 2012 Jan 24. PMID 22273551, Free PMC Article
  3. Knockout of zebrafish colony-stimulating factor 1 receptor by CRISPR/Cas9 affects metabolism and locomotion capacity. Meng H, et al. Biochem Biophys Res Commun, 2021 Apr 30. PMID 33725575
  4. An osteosarcoma zebrafish model implicates Mmp-19 and Ets-1 as well as reduced host immune response in angiogenesis and migration. Mohseny AB, et al. J Pathol, 2012 Jun. PMID 22297719
  5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within brain development IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within lipid transport IEA
Inferred from Electronic Annotation
more info
  
involved_in response to reactive oxygen species IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within tissue regeneration IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
apolipoprotein Da, duplicate 2
Names
apolipoprotein D-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001201348.1 → NP_001188277.1  apolipoprotein Da, duplicate 2 precursor

    See identical proteins and their annotated locations for NP_001188277.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, 3, and 4 encode the same protein.
    Source sequence(s)
    DY569710, EH539771, EH543264
    UniProtKB/TrEMBL
    A0A8M1P3E0, E7F2R8
    Related
    ENSDARP00000113343.1, ENSDART00000138952.3
    Conserved Domains (1) summary
    cl21528
    Location:36 → 180
    Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family

  2. NM_001201349.1 → NP_001188278.1  apolipoprotein Da, duplicate 2 precursor

    See identical proteins and their annotated locations for NP_001188278.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, and 4 encode the same protein.
    Source sequence(s)
    DY569710, EH543264
    UniProtKB/TrEMBL
    A0A8M1P3E0, E7F2R8
    Related
    ENSDARP00000117077.1, ENSDART00000132856.3
    Conserved Domains (1) summary
    cl21528
    Location:36 → 180
    Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family

  3. NM_001201350.1 → NP_001188279.1  apolipoprotein Da, duplicate 2 precursor

    See identical proteins and their annotated locations for NP_001188279.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, and 4 encode the same protein.
    Source sequence(s)
    DY569710, EH539771, EH543264
    UniProtKB/TrEMBL
    A0A8M1P3E0, E7F2R8
    Related
    ENSDARP00000123418.1, ENSDART00000143468.2
    Conserved Domains (1) summary
    cl21528
    Location:36 → 180
    Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family

  4. NM_001201351.1 → NP_001188280.1  apolipoprotein Da, duplicate 2 precursor

    See identical proteins and their annotated locations for NP_001188280.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, and 4 encode the same protein.
    Source sequence(s)
    DY569710, EH505051, EH543264
    UniProtKB/TrEMBL
    A0A8M1P3E0, E7F2R8
    Related
    ENSDARP00000123122.1, ENSDART00000137272.3
    Conserved Domains (1) summary
    cl21528
    Location:36 → 180
    Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007113.7 Reference GRCz11 Primary Assembly

    Range
    37207462..37215987
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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