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npl N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase) [ Danio rerio (zebrafish) ]

Gene ID: 100148292, updated on 28-Oct-2024

Summary

Official Symbol
nplprovided by ZNC
Official Full Name
N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase)provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-926
See related
Ensembl:ENSDARG00000009390 AllianceGenome:ZFIN:ZDB-GENE-030131-926
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:76930; wu:fb53b06
Summary
Predicted to enable N-acetylneuraminate lyase activity. Acts upstream of or within N-acetylneuraminate catabolic process. Predicted to be located in cytoplasm. Is expressed in several structures, including fin bud; gut; muscle; vein; and yolk syncytial layer. Used to study myopathy. Orthologous to human NPL (N-acetylneuraminate pyruvate lyase). [provided by Alliance of Genome Resources, Oct 2024]
Orthologs
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Genomic context

See npl in Genome Data Viewer
Location:
chromosome: 8
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (19489959..19500063)
105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (19458006..19467978)

Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene zgc:92140 Neighboring gene ER degradation enhancer, mannosidase alpha-like 3 Neighboring gene si:ch73-281k2.5 Neighboring gene SEC22 homolog B, vesicle trafficking protein b

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

General gene information

Markers

Clone Names

  • MGC76930, MGC174793

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables N-acetylneuraminate lyase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables N-acetylneuraminate lyase activity IEA
Inferred from Electronic Annotation
more info
 
enables N-acetylneuraminate lyase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables lyase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in N-acetylneuraminate catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in N-acetylneuraminate catabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within N-acetylneuraminate catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in N-acetylneuraminate catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
N-acetylneuraminate lyase
Names
N-acetylneuraminate pyruvate-lyase
N-acetylneuraminic acid aldolase
NALase
sialate lyase
sialate-pyruvate lyase
sialic acid aldolase
sialic acid lyase
NP_996934.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_207051.2NP_996934.2  N-acetylneuraminate lyase

    See identical proteins and their annotated locations for NP_996934.2

    Status: VALIDATED

    Source sequence(s)
    CR354400, EB855384, EB868386
    UniProtKB/Swiss-Prot
    Q6NYR8
    UniProtKB/TrEMBL
    A0A8N7V087, A9C3P6
    Related
    ENSDARP00000027094.8, ENSDART00000011258.9
    Conserved Domains (1) summary
    cl21457
    Location:8274
    TIM_phosphate_binding; TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate ...

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007119.7 Reference GRCz11 Primary Assembly

    Range
    19489959..19500063
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)