kiss2 kisspeptin 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: kiss2provided by ZNC
Official Full Name: kisspeptin 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-090526-1
See related: Ensembl:ENSDARG00000077985 AllianceGenome:ZFIN:ZDB-GENE-090526-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: kiss-2
Summary: Enables kisspeptin receptor binding activity. Is expressed in central nervous system; female organism; male organism; and pleuroperitoneal region. [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 4

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	4	NC_007115.7 (16827564..16828204)
105	previous assembly	GRCz10 (GCF_000002035.5)	4	NC_007115.6 (16838588..16839228)

Chromosome 4 - NC_007115.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Kisspeptin2 regulates hormone expression in female zebrafish (Danio rerio) pituitary.
Title: Kisspeptin2 regulates hormone expression in female zebrafish (Danio rerio) pituitary.
Ectopic over expression of kiss1 may compensate for the loss of kiss2.
Title: Ectopic over expression of kiss1 may compensate for the loss of kiss2.
Distribution of Kiss2 receptor in the brain and its localization in neuroendocrine cells in the zebrafish.
Title: Distribution of Kiss2 receptor in the brain and its localization in neuroendocrine cells in the zebrafish.
These results suggest that the Bpifcl modulates kiss2 mRNA expression under the influence of testosterone in the hypothalamus of female zebrafish.
Title: Bpifcl modulates kiss2 expression under the influence of 11-ketotestosterone in female zebrafish.
results reveal the pattern of kisspeptin neurones and their connections with GnRH3 neurones in the brain, suggesting distinct mechanisms for Kiss1 and Kiss2 in regulating reproductive events in zebrafish.
Title: The distribution of kisspeptin (Kiss)1- and Kiss2-positive neurones and their connections with gonadotrophin-releasing hormone-3 neurones in the zebrafish brain.
not absolutely required for zebrafish reproduction
Title: The kiss/kissr systems are dispensable for zebrafish reproduction: evidence from gene knockout studies.
Dada show that kiss1-expressing neurons are only located in the habenular nucleus, while kiss2-expressing neurons are found in the dorsal and ventral hypothalamus.
Title: Organization of two independent kisspeptin systems derived from evolutionary-ancient kiss genes in the brain of zebrafish.
Kiss2 is the predominant regulator of gonadotropin synthesis in fish.
Title: Cloning and expression of kiss2 in the zebrafish and medaka.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables kisspeptin receptor binding	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: kisspeptin 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.