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Gon7 GON7 subunit of KEOPS complex [ Rattus norvegicus (Norway rat) ]

Gene ID: 100233176, updated on 14-Nov-2024

Summary

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Official Symbol
Gon7provided by RGD
Official Full Name
GON7 subunit of KEOPS complexprovided by RGD
Primary source
RGD:2302582
See related
AllianceGenome:RGD:2302582
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be involved in tRNA threonylcarbamoyladenosine modification. Predicted to be located in cytosol; nucleolus; and nucleoplasm. Predicted to be part of EKC/KEOPS complex. Human ortholog(s) of this gene implicated in Galloway-Mowat syndrome. Orthologous to human GON7 (GON7 subunit of KEOPS complex). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 236.3), Testes (RPKM 172.0) and 9 other tissues See more
Orthologs
human all
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Genomic context

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See Gon7 in Genome Data Viewer
Location:
6q32
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (127647389..127663276, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (121882565..121898452, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (126620597..126636484, complement)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene inositol-tetrakisphosphate 1-kinase Neighboring gene uncharacterized LOC102548189 Neighboring gene uncharacterized LOC102548370 Neighboring gene modulator of apoptosis 1 Neighboring gene lysosomal enzyme trafficking factor Neighboring gene ubiquitin protein ligase E3 component n-recognin 7 Neighboring gene nuclear nucleic acid-binding protein C1D-like Neighboring gene BTB domain containing 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in tRNA threonylcarbamoyladenosine modification ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of EKC/KEOPS complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
EKC/KEOPS complex subunit GON7
Names
GON7, KEOPS complex subunit homolog
uncharacterized protein C14orf142 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001142941.1 → NP_001136413.1  EKC/KEOPS complex subunit GON7 isoform 1

    See identical proteins and their annotated locations for NP_001136413.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript but encodes the longer isoform (1).
    Source sequence(s)
    BF414510, BF561322, BI277056, BP482938, CB612989
    UniProtKB/TrEMBL
    A0A8I5ZXB8, A6JEL5
    Conserved Domains (1) summary
    pfam15387
    Location:3 → 95
    DUF4611; Domain of unknown function (DUF4611)

  2. NM_001142942.2 → NP_001136414.1  EKC/KEOPS complex subunit GON7 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice pattern in the 3' coding region, compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    CB612989, JAXUCZ010000006
    UniProtKB/TrEMBL
    D3Z9A4
    Conserved Domains (1) summary
    pfam15387
    Location:3 → 70
    DUF4611; Domain of unknown function (DUF4611)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    127647389..127663276 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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