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TTC34 tetratricopeptide repeat domain 34 [ Homo sapiens (human) ]

Gene ID: 100287898, updated on 17-Sep-2024

Summary

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Official Symbol
TTC34provided by HGNC
Official Full Name
tetratricopeptide repeat domain 34provided by HGNC
Primary source
HGNC:HGNC:34297
See related
Ensembl:ENSG00000215912 AllianceGenome:HGNC:34297
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Broad expression in testis (RPKM 2.4), thyroid (RPKM 0.8) and 14 other tissues See more
Orthologs
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Genomic context

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See TTC34 in Genome Data Viewer
Location:
1p36.32
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (2636986..2801693, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (2078230..2301463, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (2568425..2718258, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:2519024-2519656 Neighboring gene peroxiredoxin like 2B Neighboring gene ReSE screen-validated silencer GRCh37_chr1:2556762-2557011 Neighboring gene Sharpr-MPRA regulatory region 11692 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:2562185-2562685 Neighboring gene membrane metalloendopeptidase like 1 Neighboring gene MPRA-validated peak16 silencer Neighboring gene MMEL1 antisense RNA 1 Neighboring gene OCT4-H3K4me1 hESC enhancer GRCh37_chr1:2586483-2586987 Neighboring gene Sharpr-MPRA regulatory region 15700 Neighboring gene OCT4 hESC enhancer GRCh37_chr1:2587878-2588769 Neighboring gene OCT4-H3K4me1 hESC enhancer GRCh37_chr1:2588891-2589402 Neighboring gene OCT4-H3K4me1 hESC enhancer GRCh37_chr1:2589915-2590426 Neighboring gene OCT4-H3K4me1 hESC enhancer GRCh37_chr1:2597430-2597930 Neighboring gene OCT4-H3K4me1 hESC enhancer GRCh37_chr1:2597931-2598431 Neighboring gene OCT4 hESC enhancer GRCh37_chr1:2600600-2601101 Neighboring gene OCT4-H3K4me1 hESC enhancer GRCh37_chr1:2601784-2602520 Neighboring gene OCT4-H3K4me1 hESC enhancer GRCh37_chr1:2603256-2603991 Neighboring gene OCT4 hESC enhancer GRCh37_chr1:2607057-2607636 Neighboring gene OCT4-H3K4me1 hESC enhancer GRCh37_chr1:2607637-2608216 Neighboring gene OCT4 hESC enhancer GRCh37_chr1:2609432-2609933 Neighboring gene OCT4 hESC enhancer GRCh37_chr1:2610686-2611577 Neighboring gene OCT4 hESC enhancer GRCh37_chr1:2613783-2614607 Neighboring gene OCT4 hESC enhancer GRCh37_chr1:2628928-2629429 Neighboring gene uncharacterized LOC105378602 Neighboring gene uncharacterized LOC105378601 Neighboring gene uncharacterized LOC112268220 Neighboring gene uncharacterized LOC107985732 Neighboring gene uncharacterized LOC105378600 Neighboring gene uncharacterized LOC105378598 Neighboring gene uncharacterized LOC107984904 Neighboring gene uncharacterized LOC105378599 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:2706849-2707508 Neighboring gene uncharacterized LOC124903825 Neighboring gene uncharacterized LOC124903826 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:2766741-2767242 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:2824551-2825750 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:2837727-2838286 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 57 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_6521 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:2931349-2932112 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_6546 Neighboring gene actin related protein T2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The DNA sequence and biological annotation of human chromosome 1. Gregory SG, et al. Nature, 2006 May 18. PMID 16710414
  2. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. Bennett EJ, et al. Cell, 2010 Dec 10. PMID 21145461, Free PMC Article
  3. Histone deacetylase inhibitors inhibit cervical cancer growth through Parkin acetylation-mediated mitophagy. Sun X, et al. Acta Pharm Sin B, 2022 Feb. PMID 35256949, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

General protein information

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Preferred Names
tetratricopeptide repeat protein 34
Names
TPR repeat protein 34
TPR repeat-containing protein ENSP00000383873

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001242672.3 → NP_001229601.2  tetratricopeptide repeat protein 34

    Status: VALIDATED

    Source sequence(s)
    AC242022, AL592464, AL831784
    Consensus CDS
    CCDS55565.2
    UniProtKB/TrEMBL
    A0A1C7CYW7
    Related
    ENSP00000383873.4, ENST00000401095.9
    Conserved Domains (2) summary
    sd00006
    Location:689 → 720
    TPR; TPR repeat [structural motif]
    cl26002
    Location:557 → 925
    TPR_11; TPR repeat

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    2636986..2801693 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_187515.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    187771..353522 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    2078230..2301463 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A8MYJ7.2 GenPept UniProtKB/Swiss-Prot:A8MYJ7

Gene LinkOut

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