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cdc42ep1a CDC42 effector protein (Rho GTPase binding) 1a [ Danio rerio (zebrafish) ]

Gene ID: 101883603, updated on 2-Nov-2024

Summary

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Official Symbol
cdc42ep1aprovided by ZNC
Official Full Name
CDC42 effector protein (Rho GTPase binding) 1aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-121128-3
See related
Ensembl:ENSDARG00000079549 AllianceGenome:ZFIN:ZDB-GENE-121128-3
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
si:ch211-141o9.9
Summary
Predicted to enable small GTPase binding activity. Predicted to be involved in Rho protein signal transduction; positive regulation of cellular component biogenesis; and regulation of cell shape. Predicted to be located in endomembrane system. Predicted to be active in cytoplasm; cytoskeleton; and plasma membrane. Orthologous to human CDC42EP1 (CDC42 effector protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See cdc42ep1a in Genome Data Viewer
Location:
chromosome: 12
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (19238549..19250939, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (19118818..19129047, complement)

Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene pdgfa associated protein 1a Neighboring gene SH3-domain binding protein 1 Neighboring gene si:ch211-141o9.10 Neighboring gene trinucleotide repeat containing adaptor 6Ba Neighboring gene casein kinase 1, epsilon

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. The guanine nucleotide exchange factor Net1 facilitates the specification of dorsal cell fates in zebrafish embryos by promoting maternal β-catenin activation. Wei S, et al. Cell Res, 2017 Feb. PMID 27910850, Free PMC Article
  2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  4. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables small GTPase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in Rho protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of actin filament polymerization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of pseudopodium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cell shape IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endomembrane system IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
cdc42 effector protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007123.7 Reference GRCz11 Primary Assembly

    Range
    19238549..19250939 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021480298.2 → XP_021335973.1  cdc42 effector protein 1

    UniProtKB/TrEMBL
    A0A8M9Q8Z0, E7F913
    Related
    ENSDARP00000127202.1, ENSDART00000152844.2
    Conserved Domains (2) summary
    pfam14957
    Location:112 → 228
    BORG_CEP; Cdc42 effector
    cl00113
    Location:30 → 57
    CRIB; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...

Reference GRCz11 ALT_DRER_TU_2

Genomic

  1. NW_018395301.1 Reference GRCz11 ALT_DRER_TU_2

    Range
    474491..487653 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005156182.5 → XP_005156239.2  cdc42 effector protein 1

    UniProtKB/TrEMBL
    A0A8M2B274
    Conserved Domains (2) summary
    pfam14957
    Location:112 → 228
    BORG_CEP; Cdc42 effector
    cl00113
    Location:30 → 57
    CRIB; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
Nucleotide Protein
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