fgd5b FYVE, RhoGEF and PH domain containing 5b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: fgd5bprovided by ZNC
Official Full Name: FYVE, RhoGEF and PH domain containing 5bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-130925-3
See related: AllianceGenome:ZFIN:ZDB-GENE-130925-3
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fgd5
Summary: Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be active in cytoplasm. Orthologous to human FGD5 (FYVE, RhoGEF and PH domain containing 5). [provided by Alliance of Genome Resources, Oct 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 6

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	6	NC_007117.7 (40475781..40500493)
105	previous assembly	GRCz10 (GCF_000002035.5)	6	NC_007117.6 (40493812..40502459)

Chromosome 6 - NC_007117.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables guanyl-nucleotide exchange factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables guanyl-nucleotide exchange factor activity	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: FYVE, RhoGEF and PH domain-containing protein 5b

Names: FYVE, RhoGEF and PH domain containing 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001365456.1 → NP_001352385.1 FYVE, RhoGEF and PH domain-containing protein 5b

Status: VALIDATED

Source sequence(s)

BX936393, CU463231

Conserved Domains (4) summary

cd00160
Location:791 → 939

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd13237
Location:1207 → 1293

PH2_FGD5_FGD6; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins 5 and 6 pleckstrin homology (PH) domain, C-terminus

cl17171
Location:962 → 1069

PH-like; Pleckstrin homology-like domain

cl28890
Location:1096 → 1161

FYVE_like_SF; FYVE domain like superfamily