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gdnfb glial cell derived neurotrophic factor b [ Danio rerio (zebrafish) ]

Gene ID: 101885082, updated on 28-Oct-2024

Summary

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Official Symbol
gdnfbprovided by ZNC
Official Full Name
glial cell derived neurotrophic factor bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-110609-2
See related
Ensembl:ENSDARG00000103764 AllianceGenome:ZFIN:ZDB-GENE-110609-2
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
si:ch73-311f13.2
Summary
Predicted to enable growth factor activity. Predicted to be involved in negative regulation of neuron apoptotic process; peripheral nervous system development; and positive regulation of branching involved in ureteric bud morphogenesis. Predicted to be active in extracellular space. Is expressed in testis. Human ortholog(s) of this gene implicated in several diseases, including Hirschsprung's disease; Parkinsonism; alcohol dependence; alcohol use disorder; and heroin dependence. Orthologous to human GDNF (glial cell derived neurotrophic factor). [provided by Alliance of Genome Resources, Oct 2024]
Orthologs
all
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Genomic context

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See gdnfb in Genome Data Viewer
Location:
chromosome: 5
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (7986306..7996039)
105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (7481765..7491176)

Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene opsin 4xb Neighboring gene EGF like, fibronectin type III and laminin G domains Neighboring gene NIPBL cohesin loading factor a Neighboring gene solute carrier family 1 member 3a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Loss of neurturin in frog--comparative genomics study of GDNF family ligand-receptor pairs. Hätinen T, et al. Mol Cell Neurosci, 2007 Feb. PMID 17157029
  2. Gdnf Acts as a Germ Cell-Derived Growth Factor and Regulates the Zebrafish Germ Stem Cell Niche in Autocrine- and Paracrine-Dependent Manners. Doretto LB, et al. Cells, 2022 Apr 11. PMID 35455974, Free PMC Article
  3. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables glial cell-derived neurotrophic factor receptor binding IEA
Inferred from Electronic Annotation
more info
  
enables growth factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables growth factor activity IEA
Inferred from Electronic Annotation
more info
  
enables receptor tyrosine kinase binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in negative regulation of neuron apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in peripheral nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of branching involved in ureteric bud morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
glial cell line-derived neurotrophic factor

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007116.7 Reference GRCz11 Primary Assembly

    Range
    7986306..7996039
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009301191.4 → XP_009299466.1  glial cell line-derived neurotrophic factor

    UniProtKB/TrEMBL
    A0A8M3ARX4
    Related
    ENSDARP00000131492.1, ENSDART00000168071.2
    Conserved Domains (1) summary
    pfam00019
    Location:100 → 195
    TGF_beta; Transforming growth factor beta like domain
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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Molecular Biology Databases
Research Materials