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rph3aa rabphilin 3A homolog (mouse), a [ Danio rerio (zebrafish) ]

Gene ID: 101886567, updated on 12-Sep-2024

Summary

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Official Symbol
rph3aaprovided by ZNC
Official Full Name
rabphilin 3A homolog (mouse), aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-090706-2
See related
AllianceGenome:ZFIN:ZDB-GENE-090706-2
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
rph3a; fc61h10; wu:fc61h10
Summary
Predicted to enable metal ion binding activity. Predicted to act upstream of or within intracellular protein transport. Orthologous to human RPH3A (rabphilin 3A). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See rph3aa in Genome Data Viewer
Location:
chromosome: 10
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 10 NC_007121.7 (3461749..3513643)
105 previous assembly GRCz10 (GCF_000002035.5) 10 NC_007121.6 (3461470..3510813)

Chromosome 10 - NC_007121.7Genomic Context describing neighboring genes Neighboring gene protein tyrosine phosphatase non-receptor type 11a Neighboring gene transmembrane p24 trafficking protein 2 Neighboring gene phospholipase A2 group III Neighboring gene tetratricopeptide repeat domain 28

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. A manual collection of Syt, Esyt, Rph3a, Rph3al, Doc2, and Dblc2 genes from 46 metazoan genomes--an open access resource for neuroscience and evolutionary biology. Craxton M. BMC Genomics, 2010 Jan 15. PMID 20078875, Free PMC Article
  2. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables small GTPase binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within exocytosis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in synapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
rabphilin-3A
Names
zmp:0000000709

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007121.7 Reference GRCz11 Primary Assembly

    Range
    3461749..3513643
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068223885.1 → XP_068079986.1  rabphilin-3A isoform X3

  2. XM_005172601.5 → XP_005172658.1  rabphilin-3A isoform X1

    See identical proteins and their annotated locations for XP_005172658.1

    UniProtKB/TrEMBL
    A0A8M2BJS5
    Conserved Domains (3) summary
    cd04035
    Location:298 → 421
    C2A_Rabphilin_Doc2; C2 domain first repeat present in Rabphilin and Double C2 domain
    cd08384
    Location:456 → 588
    C2B_Rabphilin_Doc2; C2 domain second repeat present in Rabphilin and Double C2 domain
    cl22851
    Location:53 → 131
    PHD_SF; PHD finger superfamily

  3. XM_005172603.5 → XP_005172660.1  rabphilin-3A isoform X2

    UniProtKB/TrEMBL
    A0A8M2BJU8
    Conserved Domains (4) summary
    cd04035
    Location:297 → 420
    C2A_Rabphilin_Doc2; C2 domain first repeat present in Rabphilin and Double C2 domain
    cd08384
    Location:455 → 587
    C2B_Rabphilin_Doc2; C2 domain second repeat present in Rabphilin and Double C2 domain
    COG3266
    Location:116 → 279
    DamX; Cell division protein DamX, binds to the septal ring, contains C-terminal SPOR domain [Cell cycle control, cell division, chromosome partitioning]
    cl22851
    Location:53 → 131
    PHD_SF; PHD finger superfamily

  4. XM_005172602.5 → XP_005172659.1  rabphilin-3A isoform X1

    See identical proteins and their annotated locations for XP_005172659.1

    UniProtKB/TrEMBL
    A0A8M2BJS5
    Conserved Domains (3) summary
    cd04035
    Location:298 → 421
    C2A_Rabphilin_Doc2; C2 domain first repeat present in Rabphilin and Double C2 domain
    cd08384
    Location:456 → 588
    C2B_Rabphilin_Doc2; C2 domain second repeat present in Rabphilin and Double C2 domain
    cl22851
    Location:53 → 131
    PHD_SF; PHD finger superfamily
Nucleotide Protein
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