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mbd4 methyl-CpG binding domain protein 4 [ Danio rerio (zebrafish) ]

Gene ID: 101887128, updated on 28-Oct-2024

Summary

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Official Symbol
mbd4provided by ZNC
Official Full Name
methyl-CpG binding domain protein 4provided by ZNC
Primary source
ZFIN:ZDB-GENE-040213-1
See related
Ensembl:ENSDARG00000110298 AllianceGenome:ZFIN:ZDB-GENE-040213-1
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Predicted to enable DNA binding activity and catalytic activity. Predicted to act upstream of or within DNA repair. Is expressed in retina and trunk. Human ortholog(s) of this gene implicated in colorectal carcinoma; esophagus squamous cell carcinoma; lung cancer; rheumatoid arthritis; and uveal melanoma. Orthologous to human MBD4 (methyl-CpG binding domain 4, DNA glycosylase). [provided by Alliance of Genome Resources, Oct 2024]
Orthologs
human mouse all
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Genomic context

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See mbd4 in Genome Data Viewer
Location:
chromosome: 8
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (54211858..54216542, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (54099020..54104912, complement)

Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene bromodomain and PHD finger containing, 1 Neighboring gene interleukin-17 receptor E Neighboring gene wu:fl23c11 Neighboring gene cysteine rich with EGF like domains 1 Neighboring gene thyrotropin-releasing hormone Neighboring gene transmembrane and coiled-coil domain family 1a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. DNA demethylation in zebrafish involves the coupling of a deaminase, a glycosylase, and gadd45. Rai K, et al. Cell, 2008 Dec 26. PMID 19109892, Free PMC Article
  2. Transient reduction of 5-methylcytosine and 5-hydroxymethylcytosine is associated with active DNA demethylation during regeneration of zebrafish fin. Hirose K, et al. Epigenetics, 2013 Sep. PMID 23880758, Free PMC Article
  3. The methyl-CpG binding domain and the evolving role of DNA methylation in animals. Hendrich B, et al. Trends Genet, 2003 May. PMID 12711219
  4. Parp inhibition prevents ten-eleven translocase enzyme activation and hyperglycemia-induced DNA demethylation. Dhliwayo N, et al. Diabetes, 2014 Sep. PMID 24722243, Free PMC Article
  5. No evidence for AID/MBD4-coupled DNA demethylation in zebrafish embryos. Shimoda N, et al. PLoS One, 2014. PMID 25536520, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
methyl-CpG-binding domain protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007119.7 Reference GRCz11 Primary Assembly

    Range
    54211858..54216542 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068223251.1 → XP_068079352.1  methyl-CpG-binding domain protein 4

    Related
    ENSDARP00000145483.1, ENSDART00000193678.1

  2. XM_068223252.1 → XP_068079353.1  methyl-CpG-binding domain protein 4

  3. XM_068223250.1 → XP_068079351.1  methyl-CpG-binding domain protein 4

  4. XM_068223249.1 → XP_068079350.1  methyl-CpG-binding domain protein 4

  5. XM_017357570.3 → XP_017213059.1  methyl-CpG-binding domain protein 4

    UniProtKB/TrEMBL
    A0A097ZPG7, A0A8M6Z033

  6. XM_068223248.1 → XP_068079349.1  methyl-CpG-binding domain protein 4

Nucleotide Protein Strain
Heading Accession and Version

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Molecular Biology Databases
Research Materials