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IQGAP2 IQ motif containing GTPase activating protein 2 [ Parus major (Great Tit) ]

Gene ID: 107216413, updated on 3-Aug-2024

Summary

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Gene symbol
IQGAP2
Gene description
IQ motif containing GTPase activating protein 2
See related
Ensembl:ENSPMJG00000016151
Gene type
protein coding
RefSeq status
MODEL
Organism
Parus major
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Neoaves; Telluraves; Australaves; Passeriformes; Paridae; Parus
Orthologs
human mouse all
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Genomic context

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See IQGAP2 in Genome Data Viewer
Location:
chromosome: Z
Exon count:
38
Annotation release Status Assembly Chr Location
102 current Parus_major1.1 (GCF_001522545.3) Z NC_031799.1 (23146780..23271795, complement)
100 previous assembly Parus_major1.0.3 (GCF_001522545.1) Z NC_029299.1 (23146781..23271780, complement)

Chromosome Z - NC_031799.1Genomic Context describing neighboring genes Neighboring gene F2R like trypsin receptor 1 Neighboring gene coagulation factor II thrombin receptor Neighboring gene coagulation factor II thrombin receptor like 2 Neighboring gene uncharacterized LOC117245628 Neighboring gene synaptic vesicle glycoprotein 2C Neighboring gene POC5 centriolar protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables actin filament binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of actin cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
ras GTPase-activating-like protein IQGAP2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Parus major Annotation Release 102 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Parus_major1.1 Primary Assembly

Genomic

  1. NC_031799.1 Reference Parus_major1.1 Primary Assembly

    Range
    23146780..23271795 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015653561.3 → XP_015509047.1  ras GTPase-activating-like protein IQGAP2 isoform X4

    Related
    ENSPMJP00000021752.1, ENSPMJT00000028311.1
    Conserved Domains (6) summary
    smart00015
    Location:688 → 708
    IQ; Calmodulin-binding motif
    cd05131
    Location:914 → 1272
    RasGAP_IQGAP2; Ras-GTPase Activating Domain of IQ motif containing GTPase activating protein 2
    smart00323
    Location:903 → 1232
    RasGAP; GTPase-activator protein for Ras-like GTPases
    cd00014
    Location:42 → 156
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    pfam00612
    Location:720 → 739
    IQ; IQ calmodulin-binding motif
    pfam03836
    Location:1366 → 1498
    RasGAP_C; RasGAP C-terminus

  2. XM_015653559.3 → XP_015509045.1  ras GTPase-activating-like protein IQGAP2 isoform X2

    Related
    ENSPMJP00000021751.1, ENSPMJT00000028310.1
    Conserved Domains (6) summary
    smart00015
    Location:772 → 792
    IQ; Calmodulin-binding motif
    cd05131
    Location:998 → 1356
    RasGAP_IQGAP2; Ras-GTPase Activating Domain of IQ motif containing GTPase activating protein 2
    smart00323
    Location:987 → 1316
    RasGAP; GTPase-activator protein for Ras-like GTPases
    cd00014
    Location:42 → 156
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    pfam00612
    Location:804 → 823
    IQ; IQ calmodulin-binding motif
    pfam03836
    Location:1450 → 1582
    RasGAP_C; RasGAP C-terminus

  3. XM_015653564.3 → XP_015509050.1  ras GTPase-activating-like protein IQGAP2 isoform X7

    Related
    ENSPMJP00000021754.1, ENSPMJT00000028313.1
    Conserved Domains (6) summary
    smart00015
    Location:539 → 559
    IQ; Calmodulin-binding motif
    cd05131
    Location:765 → 1123
    RasGAP_IQGAP2; Ras-GTPase Activating Domain of IQ motif containing GTPase activating protein 2
    smart00323
    Location:754 → 1083
    RasGAP; GTPase-activator protein for Ras-like GTPases
    cd00014
    Location:42 → 156
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    pfam00612
    Location:571 → 590
    IQ; IQ calmodulin-binding motif
    pfam03836
    Location:1217 → 1349
    RasGAP_C; RasGAP C-terminus

  4. XM_015653560.3 → XP_015509046.1  ras GTPase-activating-like protein IQGAP2 isoform X3

    Conserved Domains (6) summary
    smart00015
    Location:689 → 709
    IQ; Calmodulin-binding motif
    cd05131
    Location:915 → 1273
    RasGAP_IQGAP2; Ras-GTPase Activating Domain of IQ motif containing GTPase activating protein 2
    smart00323
    Location:904 → 1233
    RasGAP; GTPase-activator protein for Ras-like GTPases
    cd00014
    Location:42 → 156
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    pfam00612
    Location:721 → 740
    IQ; IQ calmodulin-binding motif
    pfam03836
    Location:1367 → 1499
    RasGAP_C; RasGAP C-terminus

  5. XM_015653563.3 → XP_015509049.1  ras GTPase-activating-like protein IQGAP2 isoform X6

    Conserved Domains (6) summary
    smart00015
    Location:623 → 643
    IQ; Calmodulin-binding motif
    cd05131
    Location:849 → 1207
    RasGAP_IQGAP2; Ras-GTPase Activating Domain of IQ motif containing GTPase activating protein 2
    smart00323
    Location:838 → 1167
    RasGAP; GTPase-activator protein for Ras-like GTPases
    cd00014
    Location:42 → 156
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    pfam00612
    Location:655 → 674
    IQ; IQ calmodulin-binding motif
    pfam03836
    Location:1301 → 1433
    RasGAP_C; RasGAP C-terminus

  6. XM_015653558.3 → XP_015509044.1  ras GTPase-activating-like protein IQGAP2 isoform X1

    Conserved Domains (6) summary
    smart00015
    Location:773 → 793
    IQ; Calmodulin-binding motif
    cd05131
    Location:999 → 1357
    RasGAP_IQGAP2; Ras-GTPase Activating Domain of IQ motif containing GTPase activating protein 2
    smart00323
    Location:988 → 1317
    RasGAP; GTPase-activator protein for Ras-like GTPases
    cd00014
    Location:42 → 156
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    pfam00612
    Location:805 → 824
    IQ; IQ calmodulin-binding motif
    pfam03836
    Location:1451 → 1583
    RasGAP_C; RasGAP C-terminus

  7. XM_015653562.2 → XP_015509048.1  ras GTPase-activating-like protein IQGAP2 isoform X5

    Conserved Domains (6) summary
    smart00015
    Location:773 → 793
    IQ; Calmodulin-binding motif
    cd05131
    Location:999 → 1357
    RasGAP_IQGAP2; Ras-GTPase Activating Domain of IQ motif containing GTPase activating protein 2
    smart00323
    Location:988 → 1317
    RasGAP; GTPase-activator protein for Ras-like GTPases
    cd00014
    Location:42 → 156
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    pfam00612
    Location:805 → 824
    IQ; IQ calmodulin-binding motif
    pfam03836
    Location:1451 → 1539
    RasGAP_C; RasGAP C-terminus
Nucleotide Protein
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