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UBE2C ubiquitin conjugating enzyme E2 C [ Homo sapiens (human) ]

Gene ID: 11065, updated on 5-Mar-2024

Summary

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Official Symbol
UBE2Cprovided by HGNC
Official Full Name
ubiquitin conjugating enzyme E2 Cprovided by HGNC
Primary source
HGNC:HGNC:15937
See related
Ensembl:ENSG00000175063 MIM:605574; AllianceGenome:HGNC:15937
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
UBCH10; dJ447F3.2
Summary
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, ubiquitin-conjugating enzymes, and ubiquitin-protein ligases. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein is required for the destruction of mitotic cyclins and for cell cycle progression, and may be involved in cancer progression. Multiple transcript variants encoding different isoforms have been found for this gene. Pseudogenes of this gene have been defined on chromosomes 4, 14, 15, 18, and 19. [provided by RefSeq, Aug 2013]
Expression
Biased expression in bone marrow (RPKM 14.3), lymph node (RPKM 11.0) and 13 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
20q13.12
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (45812644..45816952)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (47549141..47553438)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (44441283..44445591)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene RNA, U6atac small nuclear 38, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:44408579-44409079 Neighboring gene Sharpr-MPRA regulatory region 6194 Neighboring gene WAP four-disulfide core domain 3 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_60411 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12960 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12961 Neighboring gene deoxynucleotidyltransferase terminal interacting protein 1 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_60428 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12962 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:44447254-44447902 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:44449199-44449846 Neighboring gene troponin C2, fast skeletal type Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12963 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12964 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12965 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:44468841-44469394 Neighboring gene sorting nexin family member 21 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:44470503-44471055 Neighboring gene acyl-CoA thioesterase 8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Aberrant expression of UBE2C in endometrial cancer and its correlation to epithelial mesenchymal transition. Zhang Y, et al. Medicine (Baltimore), 2023 May 19. PMID 37335710, Free PMC Article
  2. Overexpression of Ubiquitin-Conjugating Enzyme E2C Is Associated with Worsened Prognosis in Prostate Cancer. Wu X, et al. Int J Mol Sci, 2022 Nov 10. PMID 36430352, Free PMC Article
  3. UBE2C mediated radiotherapy resistance of head and neck squamous cell carcinoma by regulating oxidative-stress-relative apoptosis. Zhou Y, et al. Aging (Albany NY), 2022 Sep 5. PMID 36069832, Free PMC Article
  4. Pan-Cancer Analyses of the Tumor Microenvironment Reveal That Ubiquitin-Conjugating Enzyme E2C Might Be a Potential Immunotherapy Target. Huang GZ, et al. J Immunol Res, 2021. PMID 34950739, Free PMC Article
  5. UBE2C affects breast cancer proliferation through the AKT/mTOR signaling pathway. Lu ZN, et al. Chin Med J (Engl), 2021 Oct 7. PMID 34620747, Free PMC Article

See all (236) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. UBE2C promotes malignancy of cutaneous squamous cell carcinoma.
    Title: UBE2C promotes malignancy of cutaneous squamous cell carcinoma.
  2. Ubiquitin-conjugating enzyme E2C (UBE2C) is a prognostic indicator for cholangiocarcinoma.
    Title: Ubiquitin-conjugating enzyme E2C (UBE2C) is a prognostic indicator for cholangiocarcinoma.
  3. Role of UBE2C in Brain Cancer Invasion and Dissemination.
    Title: Role of UBE2C in Brain Cancer Invasion and Dissemination.
  4. Identification of transcriptome characteristics of granulosa cells and the possible role of UBE2C in the pathogenesis of premature ovarian insufficiency.
    Title: Identification of transcriptome characteristics of granulosa cells and the possible role of UBE2C in the pathogenesis of premature ovarian insufficiency.
  5. Comprehensive analysis of UBE2C expression and its potential roles and mechanisms in hepatocellular carcinoma.
    Title: Comprehensive analysis of UBE2C expression and its potential roles and mechanisms in hepatocellular carcinoma.
  6. Restored UBE2C expression in islets promotes beta-cell regeneration in mice by ubiquitinating PER1.
    Title: Restored UBE2C expression in islets promotes β-cell regeneration in mice by ubiquitinating PER1.
  7. System analysis identifies UBE2C as a novel oncogene target for adrenocortical carcinoma.
    Title: System analysis identifies UBE2C as a novel oncogene target for adrenocortical carcinoma.
  8. FOXM1-regulated ZIC2 promotes the malignant phenotype of renal clear cell carcinoma by activating UBE2C/mTOR signaling pathway.
    Title: FOXM1-regulated ZIC2 promotes the malignant phenotype of renal clear cell carcinoma by activating UBE2C/mTOR signaling pathway.
  9. Aberrant expression of UBE2C in endometrial cancer and its correlation to epithelial mesenchymal transition.
    Title: Aberrant expression of UBE2C in endometrial cancer and its correlation to epithelial mesenchymal transition.
  10. Expression significance of Emi1, UBCH10 and CyclinB1 in esophageal squamous cell carcinoma.
    Title: Expression significance of Emi1, UBCH10 and CyclinB1 in esophageal squamous cell carcinoma.
Submit: New GeneRIF Correction See all GeneRIFs (100)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of ubiquitin-conjugating enzyme E2C (UBE2C) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin conjugating enzyme activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin conjugating enzyme activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ubiquitin protein ligase activity TAS
Traceable Author Statement
more info
  
enables ubiquitin-like protein ligase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
contributes_to ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in anaphase-promoting complex-dependent catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in anaphase-promoting complex-dependent catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in anaphase-promoting complex-dependent catabolic process TAS
Traceable Author Statement
more info
  
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in exit from mitosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in free ubiquitin chain polymerization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of exit from mitosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of mitotic metaphase/anaphase transition IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of ubiquitin protein ligase activity TAS
Traceable Author Statement
more info
 PubMed 
involved_in protein K11-linked ubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein K48-linked ubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of mitotic metaphase/anaphase transition IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of anaphase-promoting complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
  
part_of ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
ubiquitin-conjugating enzyme E2 C
Names
(E3-independent) E2 ubiquitin-conjugating enzyme C
E2 ubiquitin-conjugating enzyme C
cyclin-selective ubiquitin carrier protein
mitotic-specific ubiquitin-conjugating enzyme
ubiquitin conjugating enzyme E2C
ubiquitin-protein ligase C
NP_001268670.1
NP_001268671.1
NP_008950.1
NP_861515.1
NP_861516.1
NP_861517.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001281741.2 → NP_001268670.1  ubiquitin-conjugating enzyme E2 C isoform 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) has multiple differences in the central coding region but maintains the reading frame, compared to variant 1. The encoded isoform (6) is shorter, compared to isoform 1.
    Source sequence(s)
    BU171488
    Consensus CDS
    CCDS74734.1
    UniProtKB/TrEMBL
    A0A087WVK1
    Related
    ENSP00000479486.1, ENST00000617055.4
    Conserved Domains (1) summary
    cl00154
    Location:92 → 123
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

  2. NM_001281742.2 → NP_001268671.1  ubiquitin-conjugating enzyme E2 C isoform 7

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) lacks an exon in central coding region, which results in a translational frameshift, compared to variant 1. The encoded isoform (7) has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    CN354813, DB062573
    Consensus CDS
    CCDS74733.1
    UniProtKB/TrEMBL
    A0A0A0MSE8
    Related
    ENSP00000385878.2, ENST00000405520.5
    Conserved Domains (1) summary
    cl00154
    Location:33 → 72
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

  3. NM_007019.4 → NP_008950.1  ubiquitin-conjugating enzyme E2 C isoform 1

    See identical proteins and their annotated locations for NP_008950.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    BC007656, DB062573
    Consensus CDS
    CCDS13370.1
    UniProtKB/Swiss-Prot
    A6NP33, E1P5N7, G3XAB7, O00762
    UniProtKB/TrEMBL
    B2R4U3, Q5TZN3
    Related
    ENSP00000348838.4, ENST00000356455.9
    Conserved Domains (1) summary
    pfam00179
    Location:34 → 170
    UQ_con; Ubiquitin-conjugating enzyme

  4. NM_181799.3 → NP_861515.1  ubiquitin-conjugating enzyme E2 C isoform 2

    See identical proteins and their annotated locations for NP_861515.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has an alternate exon in the central coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
    Source sequence(s)
    BC007656, BU169315, DB062573
    Consensus CDS
    CCDS13371.1
    UniProtKB/Swiss-Prot
    O00762
    Related
    ENSP00000335674.3, ENST00000335046.7
    Conserved Domains (1) summary
    cl00154
    Location:33 → 152
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

  5. NM_181800.3 → NP_861516.1  ubiquitin-conjugating enzyme E2 C isoform 3

    See identical proteins and their annotated locations for NP_861516.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an in-frame exon in the central coding region, compared to variant 1. The encoded isoform (3) is shorter, compared to isoform 1.
    Source sequence(s)
    BC007656, CK904708, DB062573
    Consensus CDS
    CCDS13372.1
    UniProtKB/TrEMBL
    B2R4U3
    Related
    ENSP00000333975.5, ENST00000352551.9
    Conserved Domains (1) summary
    pfam00179
    Location:44 → 141
    UQ_con; Ubiquitin-conjugating enzyme

  6. NM_181801.4 → NP_861517.1  ubiquitin-conjugating enzyme E2 C isoform 4

    See identical proteins and their annotated locations for NP_861517.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) has an alternate 5'-terminal exon and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (4) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AL050348, BC007656, BI858659, BP227692
    Consensus CDS
    CCDS13374.1
    UniProtKB/Swiss-Prot
    O00762
    Related
    ENSP00000361649.4, ENST00000372568.4
    Conserved Domains (1) summary
    pfam00179
    Location:1 → 131
    UQ_con; Ubiquitin-conjugating enzyme

RNA

  1. NR_104036.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks two internal exons, as compared to variant 1. This variant is represented as non-coding because it lacks a significant portion of the coding region and does not encode a supported protein.
    Source sequence(s)
    BC007656, CB143441, DB062573
    Related
    ENST00000243893.10

  2. NR_104037.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) uses two alternate splice sites in internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    BC007656, CN354815, DB062573

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    45812644..45816952
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    47549141..47553438
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_181802.1: Suppressed sequence

    Description
    NM_181802.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.

  2. NM_181803.1: Suppressed sequence

    Description
    NM_181803.1: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O00762.1 GenPept UniProtKB/Swiss-Prot:O00762

Gene LinkOut

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