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CHD3 chromodomain helicase DNA binding protein 3 [ Homo sapiens (human) ]

Gene ID: 1107, updated on 3-Nov-2024

Summary

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Official Symbol
CHD3provided by HGNC
Official Full Name
chromodomain helicase DNA binding protein 3provided by HGNC
Primary source
HGNC:HGNC:1918
See related
Ensembl:ENSG00000170004 MIM:602120; AllianceGenome:HGNC:1918
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZFH; Mi-2a; SNIBCPS; Mi2-ALPHA
Summary
This gene encodes a member of the CHD family of proteins which are characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. This protein is one of the components of a histone deacetylase complex referred to as the Mi-2/NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromatin remodeling is essential for many processes including transcription. Autoantibodies against this protein are found in a subset of patients with dermatomyositis. Three alternatively spliced transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in prostate (RPKM 26.5), brain (RPKM 24.4) and 24 other tissues See more
Orthologs
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Genomic context

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See CHD3 in Genome Data Viewer
Location:
17p13.1
Exon count:
45
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (7884796..7912755)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (7790128..7818165)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (7788114..7816073)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:7759303-7759840 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11650 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:7760574-7761436 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:7761437-7762298 Neighboring gene transmembrane protein 88 Neighboring gene N-alpha-acetyltransferase 38, NatC auxiliary subunit Neighboring gene cytochrome b5 domain containing 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8146 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11653 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8147 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:7792539-7793108 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr17:7797066-7798265 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr17:7806009-7806616 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr17:7806617-7807223 Neighboring gene small Cajal body-specific RNA 21 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:7818325-7819258 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8148 Neighboring gene ring finger protein 227 Neighboring gene potassium voltage-gated channel subfamily A regulatory beta subunit 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. A severe neurocognitive phenotype caused by biallelic CHD3 variants in two siblings. Goldfarb Yaacobi R, et al. Am J Med Genet A, 2024 Apr. PMID 38116750
  2. Expressed sequence tags and chromosomal localization of cDNA clones from a subtracted retinal pigment epithelium library. Gieser L, et al. Genomics, 1992 Jul. PMID 1639417
  3. Identification of a human 17p-located cDNA encoding a protein of the Snf2-like helicase family. Aubry F, et al. Eur J Biochem, 1998 Jun 15. PMID 9688266
  4. Mi-2/NuRD: multiple complexes for many purposes. Bowen NJ, et al. Biochim Biophys Acta, 2004 Mar 15. PMID 15020045
  5. UV radiation regulates Mi-2 through protein translation and stability. Burd CJ, et al. J Biol Chem, 2008 Dec 12. PMID 18922793, Free PMC Article

See all (184) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A severe neurocognitive phenotype caused by biallelic CHD3 variants in two siblings.
    Title: A severe neurocognitive phenotype caused by biallelic CHD3 variants in two siblings.
  2. Snijders Blok-Campeau Syndrome: Description of 20 Additional Individuals with Variants in CHD3 and Literature Review.
    Title: Snijders Blok-Campeau Syndrome: Description of 20 Additional Individuals with Variants in CHD3 and Literature Review.
  3. Inherited variants in CHD3 show variable expressivity in Snijders Blok-Campeau syndrome.
    Title: Inherited variants in CHD3 show variable expressivity in Snijders Blok-Campeau syndrome.
  4. Sequence and functional differences in the ATPase domains of CHD3 and SNF2H promise potential for selective regulability and drugability.
    Title: Sequence and functional differences in the ATPase domains of CHD3 and SNF2H promise potential for selective regulability and drugability.
  5. A second cohort of CHD3 patients expands the molecular mechanisms known to cause Snijders Blok-Campeau syndrome.
    Title: A second cohort of CHD3 patients expands the molecular mechanisms known to cause Snijders Blok-Campeau syndrome.
  6. A Multi-Trait Approach Identified Genetic Variants Including a Rare Mutation in RGS3 with Impact on Abnormalities of Cardiac Structure/Function.
    Title: A Multi-Trait Approach Identified Genetic Variants Including a Rare Mutation in RGS3 with Impact on Abnormalities of Cardiac Structure/Function.
  7. It has been proposed that the functional link between chromatin remodeling by CHD3 and deSUMOylation by SENP1 provides another level of control of gene expression.
    Title: The SUMO protease SENP1 and the chromatin remodeler CHD3 interact and jointly affect chromatin accessibility and gene expression.
  8. The tandem PHD fingers of CHD3 bind histone H3 tails.
    Title: Covalent Modifications of Histone H3K9 Promote Binding of CHD3.
  9. CHD3 and CHD4 exhibit distinct nuclear localization patterns in unperturbed cells, revealing a subset of specific target genes.
    Title: CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality.
  10. Mutations in CHD3 gene is associated with cutaneous T cell lymphoma and Sezary syndrome.
    Title: The mutational landscape of cutaneous T cell lymphoma and Sézary syndrome.
Submit: New GeneRIF Correction See all GeneRIFs (16)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Snijders Blok-Campeau syndrome
MedGen: C4748701 OMIM: 618205 GeneReviews: Not available
Compare labs

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag HIV-1 Gag interacts with CHD3 as demonstrated by proximity dependent biotinylation proteomics PubMed
Tat tat Depletion of CHD3 results in derepression of latent HIV-1 LTR activity PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP hydrolysis activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ATP-dependent chromatin remodeler activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP-dependent chromatin remodeler activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA binding HDA PubMed 
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables helicase activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription cis-regulatory region binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion binding NAS
Non-traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in centrosome cycle IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in chromatin remodeling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chromatin remodeling IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in chromatin remodeling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of cell fate specification NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of stem cell differentiation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in spindle organization IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of NuRD complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of NuRD complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of NuRD complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of NuRD complex NAS
Non-traceable Author Statement
more info
 PubMed 
located_in PML body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in centriolar satellite IDA
Inferred from Direct Assay
more info
  
located_in centrosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
chromodomain-helicase-DNA-binding protein 3
Names
ATP-dependent helicase CHD3
CHD-3
hZFH
mi-2 autoantigen 240 kDa protein
zinc finger helicase
zinc-finger helicase (Snf2-like)
NP_001005271.2
NP_001005273.1
NP_005843.2
XP_005256484.1
XP_005256485.1
XP_005256486.1
XP_005256488.1
XP_006721486.1
XP_006721487.1
XP_006721491.1
XP_016879552.1
XP_016879553.1
XP_016879554.1
XP_016879555.2
XP_016879556.1
XP_016879557.1
XP_016879558.1
XP_047291146.1
XP_047291147.1
XP_047291148.1
XP_047291149.1
XP_047291150.1
XP_047291151.1
XP_047291152.1
XP_047291153.1
XP_047291154.1
XP_047291155.1
XP_047291156.1
XP_047291157.1
XP_047291158.1
XP_047291159.1
XP_047291160.1
XP_047291161.1
XP_047291162.1
XP_047291163.1
XP_047291164.1
XP_047291165.1
XP_047291166.1
XP_047291167.1
XP_047291168.1
XP_047291169.1
XP_047291170.1
XP_047291171.1
XP_047291172.1
XP_054170787.1
XP_054170788.1
XP_054170789.1
XP_054170790.1
XP_054170791.1
XP_054170792.1
XP_054170793.1
XP_054170794.1
XP_054170795.1
XP_054170796.1
XP_054170797.1
XP_054170798.1
XP_054170799.1
XP_054170800.1
XP_054170801.1
XP_054170802.1
XP_054170803.1
XP_054170804.1
XP_054170805.1
XP_054170806.1
XP_054170807.1
XP_054170808.1
XP_054170809.1
XP_054170810.1
XP_054170811.1
XP_054170812.1
XP_054170813.1
XP_054170814.1
XP_054170815.1
XP_054170816.1
XP_054170817.1
XP_054170818.1
XP_054170819.1
XP_054170820.1
XP_054170821.1
XP_054170822.1
XP_054170823.1
XP_054170824.1
XP_054170825.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001005271.3 → NP_001005271.2  chromodomain-helicase-DNA-binding protein 3 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and CDS, compared to variant 1, resulting in a longer protein (isoform 3) that has a distinct N-terminus, compared to isoform 1. The transcript is supported by ESTs and an mRNA but the predicted protein has not yet been confirmed experimentally.
    Source sequence(s)
    AC104581, AF064844, AK125928, BC110648, BX283837, U91543
    Consensus CDS
    CCDS32553.2
    UniProtKB/Swiss-Prot
    Q12873
    UniProtKB/TrEMBL
    B3KWV4, Q2TAZ1
    Related
    ENSP00000369716.4, ENST00000380358.9
    Conserved Domains (11) summary
    smart00298
    Location:692 → 744
    CHROMO; Chromatin organization modifier domain
    COG1111
    Location:938 → 1317
    MPH1; ERCC4-related helicase [Replication, recombination and repair]
    cd00046
    Location:815 → 973
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    cd15531
    Location:440 → 482
    PHD1_CHD_II; PHD finger 1 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    cd15532
    Location:517 → 559
    PHD2_CHD_II; PHD finger 2 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    pfam00176
    Location:798 → 1094
    SNF2_N; SNF2 family N-terminal domain
    pfam00271
    Location:1118 → 1233
    Helicase_C; Helicase conserved C-terminal domain
    pfam06461
    Location:1437 → 1576
    DUF1086; Domain of Unknown Function (DUF1086)
    pfam06465
    Location:1371 → 1415
    DUF1087; Domain of Unknown Function (DUF1087)
    pfam08073
    Location:207 → 259
    CHDNT; CHDNT (NUC034) domain
    pfam08074
    Location:1795 → 1966
    CHDCT2; CHDCT2 (NUC038) domain

  2. NM_001005273.3 → NP_001005273.1  chromodomain-helicase-DNA-binding protein 3 isoform 1

    See identical proteins and their annotated locations for NP_001005273.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variant 1 encodes isoform 1.
    Source sequence(s)
    AC104581, AK125928, BC110648, U91543
    Consensus CDS
    CCDS32554.1
    UniProtKB/Swiss-Prot
    D3DTQ9, E9PG89, Q12873, Q9Y4I0
    Related
    ENSP00000332628.7, ENST00000330494.12
    Conserved Domains (11) summary
    smart00298
    Location:633 → 685
    CHROMO; Chromatin organization modifier domain
    COG1111
    Location:879 → 1258
    MPH1; ERCC4-related helicase [Replication, recombination and repair]
    cd00046
    Location:756 → 914
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    cd15531
    Location:381 → 423
    PHD1_CHD_II; PHD finger 1 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    cd15532
    Location:458 → 500
    PHD2_CHD_II; PHD finger 2 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    pfam00176
    Location:739 → 1035
    SNF2_N; SNF2 family N-terminal domain
    pfam00271
    Location:1059 → 1174
    Helicase_C; Helicase conserved C-terminal domain
    pfam06461
    Location:1378 → 1517
    DUF1086; Domain of Unknown Function (DUF1086)
    pfam06465
    Location:1312 → 1356
    DUF1087; Domain of Unknown Function (DUF1087)
    pfam08073
    Location:148 → 200
    CHDNT; CHDNT (NUC034) domain
    pfam08074
    Location:1736 → 1907
    CHDCT2; CHDCT2 (NUC038) domain

  3. NM_005852.4 → NP_005843.2  chromodomain-helicase-DNA-binding protein 3 isoform 2

    See identical proteins and their annotated locations for NP_005843.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' CDS, compared to variant 1. The resulting protein (isoform 2) is shorter, compared to isoform 1.
    Source sequence(s)
    AC104581, AK125928, BC110648, U91543
    Consensus CDS
    CCDS32555.1
    UniProtKB/Swiss-Prot
    Q12873
    UniProtKB/TrEMBL
    B3KWV4, Q2TAZ1
    Related
    ENSP00000350907.4, ENST00000358181.8
    Conserved Domains (12) summary
    PHA03418
    Location:1519 → 1654
    PHA03418; hypothetical E4 protein; Provisional
    smart00298
    Location:633 → 685
    CHROMO; Chromatin organization modifier domain
    COG1111
    Location:879 → 1258
    MPH1; ERCC4-related helicase [Replication, recombination and repair]
    cd00046
    Location:756 → 914
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    cd15531
    Location:381 → 423
    PHD1_CHD_II; PHD finger 1 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    cd15532
    Location:458 → 500
    PHD2_CHD_II; PHD finger 2 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    pfam00176
    Location:739 → 1035
    SNF2_N; SNF2 family N-terminal domain
    pfam00271
    Location:1059 → 1174
    Helicase_C; Helicase conserved C-terminal domain
    pfam06461
    Location:1378 → 1517
    DUF1086; Domain of Unknown Function (DUF1086)
    pfam06465
    Location:1312 → 1356
    DUF1087; Domain of Unknown Function (DUF1087)
    pfam08073
    Location:148 → 200
    CHDNT; CHDNT (NUC034) domain
    pfam08074
    Location:1702 → 1873
    CHDCT2; CHDCT2 (NUC038) domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    7884796..7912755
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005256427.5 → XP_005256484.1  chromodomain-helicase-DNA-binding protein 3 isoform X1

    Conserved Domains (11) summary
    smart00298
    Location:692 → 744
    CHROMO; Chromatin organization modifier domain
    COG1111
    Location:938 → 1317
    MPH1; ERCC4-related helicase [Replication, recombination and repair]
    cd00046
    Location:815 → 973
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    cd15531
    Location:440 → 482
    PHD1_CHD_II; PHD finger 1 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    cd15532
    Location:517 → 559
    PHD2_CHD_II; PHD finger 2 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    pfam00176
    Location:798 → 1094
    SNF2_N; SNF2 family N-terminal domain
    pfam00271
    Location:1118 → 1233
    Helicase_C; Helicase conserved C-terminal domain
    pfam06461
    Location:1437 → 1576
    DUF1086; Domain of Unknown Function (DUF1086)
    pfam06465
    Location:1371 → 1415
    DUF1087; Domain of Unknown Function (DUF1087)
    pfam08073
    Location:207 → 259
    CHDNT; CHDNT (NUC034) domain
    pfam08074
    Location:1796 → 1923
    CHDCT2; CHDCT2 (NUC038) domain

  2. XM_005256429.5 → XP_005256486.1  chromodomain-helicase-DNA-binding protein 3 isoform X7

    Conserved Domains (11) summary
    smart00298
    Location:692 → 744
    CHROMO; Chromatin organization modifier domain
    COG1111
    Location:938 → 1317
    MPH1; ERCC4-related helicase [Replication, recombination and repair]
    cd00046
    Location:815 → 973
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    cd15531
    Location:440 → 482
    PHD1_CHD_II; PHD finger 1 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    cd15532
    Location:517 → 559
    PHD2_CHD_II; PHD finger 2 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    pfam00176
    Location:798 → 1094
    SNF2_N; SNF2 family N-terminal domain
    pfam00271
    Location:1118 → 1233
    Helicase_C; Helicase conserved C-terminal domain
    pfam06461
    Location:1437 → 1576
    DUF1086; Domain of Unknown Function (DUF1086)
    pfam06465
    Location:1371 → 1415
    DUF1087; Domain of Unknown Function (DUF1087)
    pfam08073
    Location:207 → 259
    CHDNT; CHDNT (NUC034) domain
    pfam08074
    Location:1796 → 1967
    CHDCT2; CHDCT2 (NUC038) domain

  3. XM_006721423.4 → XP_006721486.1  chromodomain-helicase-DNA-binding protein 3 isoform X2

    UniProtKB/TrEMBL
    A0A8V8TR54
    Related
    ENSP00000515165.1, ENST00000700753.1
    Conserved Domains (11) summary
    smart00298
    Location:692 → 744
    CHROMO; Chromatin organization modifier domain
    COG1111
    Location:938 → 1317
    MPH1; ERCC4-related helicase [Replication, recombination and repair]
    cd00046
    Location:815 → 973
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    cd15531
    Location:440 → 482
    PHD1_CHD_II; PHD finger 1 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    cd15532
    Location:517 → 559
    PHD2_CHD_II; PHD finger 2 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    pfam00176
    Location:798 → 1094
    SNF2_N; SNF2 family N-terminal domain
    pfam00271
    Location:1118 → 1233
    Helicase_C; Helicase conserved C-terminal domain
    pfam06461
    Location:1437 → 1576
    DUF1086; Domain of Unknown Function (DUF1086)
    pfam06465
    Location:1371 → 1415
    DUF1087; Domain of Unknown Function (DUF1087)
    pfam08073
    Location:207 → 259
    CHDNT; CHDNT (NUC034) domain
    pfam08074
    Location:1795 → 1922
    CHDCT2; CHDCT2 (NUC038) domain

  4. XM_005256428.5 → XP_005256485.1  chromodomain-helicase-DNA-binding protein 3 isoform X5

    Conserved Domains (12) summary
    PHA03418
    Location:1578 → 1713
    PHA03418; hypothetical E4 protein; Provisional
    smart00298
    Location:692 → 744
    CHROMO; Chromatin organization modifier domain
    COG1111
    Location:938 → 1317
    MPH1; ERCC4-related helicase [Replication, recombination and repair]
    cd00046
    Location:815 → 973
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    cd15531
    Location:440 → 482
    PHD1_CHD_II; PHD finger 1 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    cd15532
    Location:517 → 559
    PHD2_CHD_II; PHD finger 2 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    pfam00176
    Location:798 → 1094
    SNF2_N; SNF2 family N-terminal domain
    pfam00271
    Location:1118 → 1233
    Helicase_C; Helicase conserved C-terminal domain
    pfam06461
    Location:1437 → 1576
    DUF1086; Domain of Unknown Function (DUF1086)
    pfam06465
    Location:1371 → 1415
    DUF1087; Domain of Unknown Function (DUF1087)
    pfam08073
    Location:207 → 259
    CHDNT; CHDNT (NUC034) domain
    pfam08074
    Location:1761 → 1888
    CHDCT2; CHDCT2 (NUC038) domain

  5. XM_006721428.4 → XP_006721491.1  chromodomain-helicase-DNA-binding protein 3 isoform X22

    Conserved Domains (12) summary
    PHA03418
    Location:1578 → 1713
    PHA03418; hypothetical E4 protein; Provisional
    smart00298
    Location:692 → 744
    CHROMO; Chromatin organization modifier domain
    COG1111
    Location:938 → 1317
    MPH1; ERCC4-related helicase [Replication, recombination and repair]
    cd00046
    Location:815 → 973
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    cd15531
    Location:440 → 482
    PHD1_CHD_II; PHD finger 1 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    cd15532
    Location:517 → 559
    PHD2_CHD_II; PHD finger 2 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    pfam00176
    Location:798 → 1094
    SNF2_N; SNF2 family N-terminal domain
    pfam00271
    Location:1118 → 1233
    Helicase_C; Helicase conserved C-terminal domain
    pfam06461
    Location:1437 → 1576
    DUF1086; Domain of Unknown Function (DUF1086)
    pfam06465
    Location:1371 → 1415
    DUF1087; Domain of Unknown Function (DUF1087)
    pfam08073
    Location:207 → 259
    CHDNT; CHDNT (NUC034) domain
    pfam08074
    Location:1761 → 1932
    CHDCT2; CHDCT2 (NUC038) domain

  6. XM_017024065.2 → XP_016879554.1  chromodomain-helicase-DNA-binding protein 3 isoform X14

  7. XM_047435206.1 → XP_047291162.1  chromodomain-helicase-DNA-binding protein 3 isoform X27

  8. XM_047435196.1 → XP_047291152.1  chromodomain-helicase-DNA-binding protein 3 isoform X15

  9. XM_047435207.1 → XP_047291163.1  chromodomain-helicase-DNA-binding protein 3 isoform X28

  10. XM_047435213.1 → XP_047291169.1  chromodomain-helicase-DNA-binding protein 3 isoform X34

  11. XM_006721424.4 → XP_006721487.1  chromodomain-helicase-DNA-binding protein 3 isoform X3

    Conserved Domains (11) summary
    smart00298
    Location:688 → 740
    CHROMO; Chromatin organization modifier domain
    COG1111
    Location:934 → 1313
    MPH1; ERCC4-related helicase [Replication, recombination and repair]
    cd00046
    Location:811 → 969
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    cd15531
    Location:436 → 478
    PHD1_CHD_II; PHD finger 1 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    cd15532
    Location:513 → 555
    PHD2_CHD_II; PHD finger 2 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    pfam00176
    Location:794 → 1090
    SNF2_N; SNF2 family N-terminal domain
    pfam00271
    Location:1114 → 1229
    Helicase_C; Helicase conserved C-terminal domain
    pfam06461
    Location:1433 → 1572
    DUF1086; Domain of Unknown Function (DUF1086)
    pfam06465
    Location:1367 → 1411
    DUF1087; Domain of Unknown Function (DUF1087)
    pfam08073
    Location:207 → 259
    CHDNT; CHDNT (NUC034) domain
    pfam08074
    Location:1792 → 1919
    CHDCT2; CHDCT2 (NUC038) domain

  12. XM_047435192.1 → XP_047291148.1  chromodomain-helicase-DNA-binding protein 3 isoform X8

  13. XM_047435190.1 → XP_047291146.1  chromodomain-helicase-DNA-binding protein 3 isoform X4

  14. XM_017024064.2 → XP_016879553.1  chromodomain-helicase-DNA-binding protein 3 isoform X10

  15. XM_047435191.1 → XP_047291147.1  chromodomain-helicase-DNA-binding protein 3 isoform X6

  16. XM_047435202.1 → XP_047291158.1  chromodomain-helicase-DNA-binding protein 3 isoform X23

  17. XM_047435198.1 → XP_047291154.1  chromodomain-helicase-DNA-binding protein 3 isoform X18

  18. XM_047435208.1 → XP_047291164.1  chromodomain-helicase-DNA-binding protein 3 isoform X29

  19. XM_047435214.1 → XP_047291170.1  chromodomain-helicase-DNA-binding protein 3 isoform X35

  20. XM_005256431.5 → XP_005256488.1  chromodomain-helicase-DNA-binding protein 3 isoform X38

    UniProtKB/TrEMBL
    A0A5F9ZHX5
    Conserved Domains (7) summary
    smart00298
    Location:692 → 744
    CHROMO; Chromatin organization modifier domain
    cd00046
    Location:815 → 973
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    cd15531
    Location:440 → 482
    PHD1_CHD_II; PHD finger 1 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    cd15532
    Location:517 → 559
    PHD2_CHD_II; PHD finger 2 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    pfam00176
    Location:798 → 1094
    SNF2_N; SNF2 family N-terminal domain
    pfam00271
    Location:1118 → 1185
    Helicase_C; Helicase conserved C-terminal domain
    pfam08073
    Location:207 → 259
    CHDNT; CHDNT (NUC034) domain

  21. XM_047435210.1 → XP_047291166.1  chromodomain-helicase-DNA-binding protein 3 isoform X31

  22. XM_017024067.3 → XP_016879556.1  chromodomain-helicase-DNA-binding protein 3 isoform X17

    Conserved Domains (11) summary
    smart00298
    Location:622 → 674
    CHROMO; Chromatin organization modifier domain
    COG1111
    Location:868 → 1247
    MPH1; ERCC4-related helicase [Replication, recombination and repair]
    cd00046
    Location:745 → 903
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    cd15531
    Location:370 → 412
    PHD1_CHD_II; PHD finger 1 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    cd15532
    Location:447 → 489
    PHD2_CHD_II; PHD finger 2 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    pfam00176
    Location:728 → 1024
    SNF2_N; SNF2 family N-terminal domain
    pfam00271
    Location:1048 → 1163
    Helicase_C; Helicase conserved C-terminal domain
    pfam06461
    Location:1367 → 1506
    DUF1086; Domain of Unknown Function (DUF1086)
    pfam06465
    Location:1301 → 1345
    DUF1087; Domain of Unknown Function (DUF1087)
    pfam08073
    Location:137 → 189
    CHDNT; CHDNT (NUC034) domain
    pfam08074
    Location:1726 → 1853
    CHDCT2; CHDCT2 (NUC038) domain

  23. XM_017024068.2 → XP_016879557.1  chromodomain-helicase-DNA-binding protein 3 isoform X19

    Conserved Domains (11) summary
    smart00298
    Location:613 → 665
    CHROMO; Chromatin organization modifier domain
    COG1111
    Location:859 → 1238
    MPH1; ERCC4-related helicase [Replication, recombination and repair]
    cd00046
    Location:736 → 894
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    cd15531
    Location:361 → 403
    PHD1_CHD_II; PHD finger 1 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    cd15532
    Location:438 → 480
    PHD2_CHD_II; PHD finger 2 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    pfam00176
    Location:719 → 1015
    SNF2_N; SNF2 family N-terminal domain
    pfam00271
    Location:1039 → 1154
    Helicase_C; Helicase conserved C-terminal domain
    pfam06461
    Location:1358 → 1497
    DUF1086; Domain of Unknown Function (DUF1086)
    pfam06465
    Location:1292 → 1336
    DUF1087; Domain of Unknown Function (DUF1087)
    pfam08073
    Location:128 → 180
    CHDNT; CHDNT (NUC034) domain
    pfam08074
    Location:1717 → 1844
    CHDCT2; CHDCT2 (NUC038) domain

  24. XM_047435211.1 → XP_047291167.1  chromodomain-helicase-DNA-binding protein 3 isoform X32

  25. XM_047435204.1 → XP_047291160.1  chromodomain-helicase-DNA-binding protein 3 isoform X25

  26. XM_047435197.1 → XP_047291153.1  chromodomain-helicase-DNA-binding protein 3 isoform X17

  27. XM_047435199.1 → XP_047291155.1  chromodomain-helicase-DNA-binding protein 3 isoform X19

  28. XM_047435209.1 → XP_047291165.1  chromodomain-helicase-DNA-binding protein 3 isoform X30

  29. XM_047435200.1 → XP_047291156.1  chromodomain-helicase-DNA-binding protein 3 isoform X20

  30. XM_047435201.1 → XP_047291157.1  chromodomain-helicase-DNA-binding protein 3 isoform X21

  31. XM_047435215.1 → XP_047291171.1  chromodomain-helicase-DNA-binding protein 3 isoform X36

  32. XM_047435216.1 → XP_047291172.1  chromodomain-helicase-DNA-binding protein 3 isoform X37

  33. XM_017024066.2 → XP_016879555.2  chromodomain-helicase-DNA-binding protein 3 isoform X16

  34. XM_017024069.2 → XP_016879558.1  chromodomain-helicase-DNA-binding protein 3 isoform X37

  35. XM_017024063.2 → XP_016879552.1  chromodomain-helicase-DNA-binding protein 3 isoform X9

  36. XM_047435193.1 → XP_047291149.1  chromodomain-helicase-DNA-binding protein 3 isoform X11

  37. XM_047435194.1 → XP_047291150.1  chromodomain-helicase-DNA-binding protein 3 isoform X12

  38. XM_047435203.1 → XP_047291159.1  chromodomain-helicase-DNA-binding protein 3 isoform X24

  39. XM_047435195.1 → XP_047291151.1  chromodomain-helicase-DNA-binding protein 3 isoform X13

  40. XM_047435205.1 → XP_047291161.1  chromodomain-helicase-DNA-binding protein 3 isoform X26

  41. XM_047435212.1 → XP_047291168.1  chromodomain-helicase-DNA-binding protein 3 isoform X33

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    7790128..7818165
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054314812.1 → XP_054170787.1  chromodomain-helicase-DNA-binding protein 3 isoform X1

  2. XM_054314818.1 → XP_054170793.1  chromodomain-helicase-DNA-binding protein 3 isoform X7

  3. XM_054314813.1 → XP_054170788.1  chromodomain-helicase-DNA-binding protein 3 isoform X2

    UniProtKB/TrEMBL
    A0A8V8TR54

  4. XM_054314816.1 → XP_054170791.1  chromodomain-helicase-DNA-binding protein 3 isoform X5

  5. XM_054314834.1 → XP_054170809.1  chromodomain-helicase-DNA-binding protein 3 isoform X22

  6. XM_054314825.1 → XP_054170800.1  chromodomain-helicase-DNA-binding protein 3 isoform X14

  7. XM_054314839.1 → XP_054170814.1  chromodomain-helicase-DNA-binding protein 3 isoform X27

  8. XM_054314826.1 → XP_054170801.1  chromodomain-helicase-DNA-binding protein 3 isoform X15

  9. XM_054314840.1 → XP_054170815.1  chromodomain-helicase-DNA-binding protein 3 isoform X28

  10. XM_054314846.1 → XP_054170821.1  chromodomain-helicase-DNA-binding protein 3 isoform X34

  11. XM_054314814.1 → XP_054170789.1  chromodomain-helicase-DNA-binding protein 3 isoform X3

  12. XM_054314819.1 → XP_054170794.1  chromodomain-helicase-DNA-binding protein 3 isoform X8

  13. XM_054314815.1 → XP_054170790.1  chromodomain-helicase-DNA-binding protein 3 isoform X4

  14. XM_054314821.1 → XP_054170796.1  chromodomain-helicase-DNA-binding protein 3 isoform X10

  15. XM_054314817.1 → XP_054170792.1  chromodomain-helicase-DNA-binding protein 3 isoform X6

  16. XM_054314835.1 → XP_054170810.1  chromodomain-helicase-DNA-binding protein 3 isoform X23

  17. XM_054314829.1 → XP_054170804.1  chromodomain-helicase-DNA-binding protein 3 isoform X18

  18. XM_054314841.1 → XP_054170816.1  chromodomain-helicase-DNA-binding protein 3 isoform X29

  19. XM_054314847.1 → XP_054170822.1  chromodomain-helicase-DNA-binding protein 3 isoform X35

  20. XM_054314850.1 → XP_054170825.1  chromodomain-helicase-DNA-binding protein 3 isoform X38

  21. XM_054314843.1 → XP_054170818.1  chromodomain-helicase-DNA-binding protein 3 isoform X31

  22. XM_054314831.1 → XP_054170806.1  chromodomain-helicase-DNA-binding protein 3 isoform X19

  23. XM_054314830.1 → XP_054170805.1  chromodomain-helicase-DNA-binding protein 3 isoform X19

  24. XM_054314844.1 → XP_054170819.1  chromodomain-helicase-DNA-binding protein 3 isoform X32

  25. XM_054314837.1 → XP_054170812.1  chromodomain-helicase-DNA-binding protein 3 isoform X25

  26. XM_054314842.1 → XP_054170817.1  chromodomain-helicase-DNA-binding protein 3 isoform X30

  27. XM_054314832.1 → XP_054170807.1  chromodomain-helicase-DNA-binding protein 3 isoform X20

  28. XM_054314833.1 → XP_054170808.1  chromodomain-helicase-DNA-binding protein 3 isoform X21

  29. XM_054314848.1 → XP_054170823.1  chromodomain-helicase-DNA-binding protein 3 isoform X36

  30. XM_054314828.1 → XP_054170803.1  chromodomain-helicase-DNA-binding protein 3 isoform X17

  31. XM_054314849.1 → XP_054170824.1  chromodomain-helicase-DNA-binding protein 3 isoform X37

  32. XM_054314820.1 → XP_054170795.1  chromodomain-helicase-DNA-binding protein 3 isoform X9

  33. XM_054314822.1 → XP_054170797.1  chromodomain-helicase-DNA-binding protein 3 isoform X11

  34. XM_054314823.1 → XP_054170798.1  chromodomain-helicase-DNA-binding protein 3 isoform X12

  35. XM_054314836.1 → XP_054170811.1  chromodomain-helicase-DNA-binding protein 3 isoform X24

  36. XM_054314824.1 → XP_054170799.1  chromodomain-helicase-DNA-binding protein 3 isoform X13

  37. XM_054314838.1 → XP_054170813.1  chromodomain-helicase-DNA-binding protein 3 isoform X26

  38. XM_054314845.1 → XP_054170820.1  chromodomain-helicase-DNA-binding protein 3 isoform X33

  39. XM_054314827.1 → XP_054170802.1  chromodomain-helicase-DNA-binding protein 3 isoform X39

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001272.1: Suppressed sequence

    Description
    NM_001272.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q12873.3 GenPept UniProtKB/Swiss-Prot:Q12873

Gene LinkOut

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