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CIT citron rho-interacting serine/threonine kinase [ Homo sapiens (human) ]

Gene ID: 11113, updated on 2-Nov-2024

Summary

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Official Symbol
CITprovided by HGNC
Official Full Name
citron rho-interacting serine/threonine kinaseprovided by HGNC
Primary source
HGNC:HGNC:1985
See related
Ensembl:ENSG00000122966 MIM:605629; AllianceGenome:HGNC:1985
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CITK; CRIK; STK21; MCPH17
Summary
This gene encodes a serine/threonine-protein kinase that functions in cell division. Together with the kinesin KIF14, this protein localizes to the central spindle and midbody, and functions to promote efficient cytokinesis. This protein is involved in central nervous system development. Polymorphisms in this gene are associated with bipolar disorder and risk for schizophrenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]
Expression
Broad expression in brain (RPKM 9.1), testis (RPKM 3.2) and 18 other tissues See more
Orthologs
mouse all
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Genomic context

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See CIT in Genome Data Viewer
Location:
12q24.23
Exon count:
51
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (119685791..119877320, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (119673075..119864647, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (120123596..120315124, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370027 Neighboring gene transmembrane protein 233 Neighboring gene RN7SK pseudogene 197 Neighboring gene GATA motif-containing MPRA enhancer 88 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4930 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7115 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:120106633-120107268 Neighboring gene uncharacterized LOC124903033 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:120115207-120115708 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:120115709-120116208 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr12:120117012-120118211 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7116 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7117 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:120125555-120126425 Neighboring gene protein kinase AMP-activated non-catalytic subunit beta 1 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr12:120185956-120187155 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:120192166-120192349 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:120197803-120197989 Neighboring gene microRNA 1178 Neighboring gene NANOG hESC enhancer GRCh37_chr12:120213039-120213640 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:120242131-120242682 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr12:120306702-120307901 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7118 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4931 Neighboring gene uncharacterized LOC112268087 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7119 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:120423527-120423708 Neighboring gene ribosomal protein L35a pseudogene 30 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:120426711-120427684 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4932 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:120427685-120428656 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:120431757-120431860 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7120 Neighboring gene BICD family like cargo adaptor 1 Neighboring gene small nucleolar RNA U13

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. [Mechanism Underlying Increased Expression of a Member of the Serine/Threonine Kinase Family (Citron kinase) Induced by HIV-1 Infection]. Ding J, et al. Bing Du Xue Bao, 2015 Jul. PMID 26524911
  2. Down-regulation of CIT can inhibit the growth of human bladder cancer cells. Liu Z, et al. Biomed Pharmacother, 2020 Apr. PMID 31972359
  3. Citron Rho-interacting kinase silencing causes cytokinesis failure and reduces tumor growth in multiple myeloma. Sahin I, et al. Blood Adv, 2019 Apr 9. PMID 30940634, Free PMC Article
  4. Citron kinase (CIT-K) promotes aggressiveness and tumorigenesis of breast cancer cells in vitro and in vivo: preliminary study of the underlying mechanism. Meng D, et al. Clin Transl Oncol, 2019 Jul. PMID 30565087
  5. Mutations in Citron Kinase Cause Recessive Microlissencephaly with Multinucleated Neurons. Harding BN, et al. Am J Hum Genet, 2016 Aug 4. PMID 27453579, Free PMC Article

See all (100) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Prostate Cancer Progression Relies on the Mitotic Kinase Citron Kinase.
    Title: Prostate Cancer Progression Relies on the Mitotic Kinase Citron Kinase.
  2. Novel circRNA_0071196/miRNA19b3p/CIT axis is associated with proliferation and migration of bladder cancer.
    Title: Novel circRNA_0071196/miRNA‑19b‑3p/CIT axis is associated with proliferation and migration of bladder cancer.
  3. Down-regulation of CIT can inhibit the growth of human bladder cancer cells.
    Title: Down-regulation of CIT can inhibit the growth of human bladder cancer cells.
  4. gene expression profile data set showed that MM patients with high CIT gene expression had significantly worse overall survival compared with MM patients with low CIT gene expression. CIT silencing in MM cell lines induced cytokinesis failure and resulted in decreased MM cell proliferation in vitro and in vivo.
    Title: Citron Rho-interacting kinase silencing causes cytokinesis failure and reduces tumor growth in multiple myeloma.
  5. CIT-K overexpression is associated with breast cancer.
    Title: Citron kinase (CIT-K) promotes aggressiveness and tumorigenesis of breast cancer cells in vitro and in vivo: preliminary study of the underlying mechanism.
  6. CITK deletion decreased tumor growth and increased overall survival in these mice, with no apparent side effects. These results suggest that CITK can be a useful molecular target for medulloblastoma treatment.
    Title: Inactivation of Citron Kinase Inhibits Medulloblastoma Progression by Inducing Apoptosis and Cell Senescence.
  7. in this study we have provided evidence that ASPM controls spindle orientation by regulating the dynamics of astral MT and that CITK is a critical downstream partner of ASPM for this activity.
    Title: ASPM and CITK regulate spindle orientation by affecting the dynamics of astral microtubules.
  8. Control of abscission requires Eph kinase activity, and Src and citron kinase (CitK) are downstream effectors in the Eph-induced signal transduction cascade
    Title: Eph-mediated tyrosine phosphorylation of citron kinase controls abscission.
  9. The striking phenotypic overlap between CIT-mutated individuals and the knockout mice and rats that are specifically deficient in the kinase domain supports the proposed causal link between CIT mutation and primary microcephaly in humans.
    Title: Mutations in CIT, encoding citron rho-interacting serine/threonine kinase, cause severe primary microcephaly in humans.
  10. Splice site variant in CIT, identified in this study, is predicted to abolish splice donor site. cDNA sequence of an affected individual showed retention of an intron next to the splice donor site. The study, presented here, revealed the first variant in the CIT causing Autosomal recessive primary microcephaly in the family.
    Title: CIT, a gene involved in neurogenic cytokinesis, is mutated in human primary microcephaly.
Submit: New GeneRIF Correction See all GeneRIFs (31)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Microcephaly 17, primary, autosomal recessive
MedGen: C4310723 OMIM: 617090 GeneReviews: Not available
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Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
HIV-1 replication is enhanced by CIT expression, which is dependent on NEDD4L expression as shown through siRNA knockdown of NEDD4L PubMed

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag HIV-1 Gag polyubiquitination is enhanced by CIT (citron kinase) PubMed
gag HIV-1 Gag interacts with the zinc finger, RhoA-binding, and leucine zipper domains of CIT (citron kinase) in HEK293T cells PubMed
gag Ectopic expression of citron kinase leads to the formation of cytoplasmic structures containing citron kinase and HIV-1 Gag proteins PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0949

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables PDZ domain binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables SH3 domain binding IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AS1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables protein serine/threonine kinase inhibitor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables scaffold protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables transcription coactivator binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in generation of neurons ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in mitotic cell cycle ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in mitotic cytokinesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of hippo signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of cytokinesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in membrane HDA PubMed 

General protein information

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Preferred Names
citron Rho-interacting kinase
Names
citron (rho-interacting, serine/threonine kinase 21)
serine/threonine kinase 21
serine/threonine-protein kinase 21
NP_001193928.1
NP_009105.1
XP_006719269.1
XP_011536085.1
XP_011536086.1
XP_011536087.1
XP_011536089.1
XP_011536090.1
XP_011536091.1
XP_011536092.1
XP_011536093.1
XP_016874224.1
XP_016874225.1
XP_016874226.1
XP_047284090.1
XP_054226823.1
XP_054226824.1
XP_054226825.1
XP_054226826.1
XP_054226827.1
XP_054226828.1
XP_054226829.1
XP_054226830.1
XP_054226831.1
XP_054226832.1
XP_054226833.1
XP_054226834.1
XP_054226835.1

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029792.2 RefSeqGene

    Range
    5000..196529
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001206999.2 → NP_001193928.1  citron Rho-interacting kinase isoform 1

    See identical proteins and their annotated locations for NP_001193928.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC004813, AY257469, AY681966
    Consensus CDS
    CCDS55891.1
    UniProtKB/Swiss-Prot
    O14578
    Related
    ENSP00000376306.2, ENST00000392521.7
    Conserved Domains (6) summary
    smart00036
    Location:1635 → 1931
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:97 → 360
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    COG1196
    Location:474 → 1335
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00029
    Location:1405 → 1453
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd05601
    Location:95 → 422
    STKc_CRIK; Catalytic domain of the Serine/Threonine Kinase, Citron Rho-interacting kinase
    pfam00169
    Location:1486 → 1605
    PH; PH domain

  2. NM_007174.3 → NP_009105.1  citron Rho-interacting kinase isoform 2

    See identical proteins and their annotated locations for NP_009105.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AC004813, AY257469, AY681966
    Consensus CDS
    CCDS9192.1
    UniProtKB/Swiss-Prot
    O14578, Q2M5E1, Q6XUH8, Q86UQ9, Q9UPZ7
    UniProtKB/TrEMBL
    H7BYJ3
    Related
    ENSP00000261833.7, ENST00000261833.11
    Conserved Domains (7) summary
    smart00036
    Location:1593 → 1889
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:97 → 360
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    COG1340
    Location:558 → 844
    COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
    COG4942
    Location:1083 → 1365
    EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
    cd00029
    Location:1363 → 1411
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd05601
    Location:95 → 422
    STKc_CRIK; Catalytic domain of the Serine/Threonine Kinase, Citron Rho-interacting kinase
    pfam00169
    Location:1444 → 1563
    PH; PH domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    119685791..119877320 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011537788.2 → XP_011536090.1  citron Rho-interacting kinase isoform X10

    UniProtKB/TrEMBL
    H7BYJ3
    Conserved Domains (7) summary
    smart00036
    Location:1578 → 1874
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:97 → 360
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    COG1340
    Location:558 → 844
    COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
    COG4942
    Location:1083 → 1350
    EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
    cd00029
    Location:1348 → 1396
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd05601
    Location:95 → 422
    STKc_CRIK; Catalytic domain of the Serine/Threonine Kinase, Citron Rho-interacting kinase
    pfam00169
    Location:1429 → 1548
    PH; PH domain

  2. XM_011537787.2 → XP_011536089.1  citron Rho-interacting kinase isoform X9

    See identical proteins and their annotated locations for XP_011536089.1

    UniProtKB/TrEMBL
    H7BYJ3
    Conserved Domains (7) summary
    smart00036
    Location:1578 → 1874
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:97 → 360
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    COG1340
    Location:558 → 844
    COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
    COG4942
    Location:1083 → 1350
    EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
    cd00029
    Location:1348 → 1396
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd05601
    Location:95 → 422
    STKc_CRIK; Catalytic domain of the Serine/Threonine Kinase, Citron Rho-interacting kinase
    pfam00169
    Location:1429 → 1548
    PH; PH domain

  3. XM_047428134.1 → XP_047284090.1  citron Rho-interacting kinase isoform X8

  4. XM_017018737.2 → XP_016874226.1  citron Rho-interacting kinase isoform X7

  5. XM_006719206.3 → XP_006719269.1  citron Rho-interacting kinase isoform X6

    Conserved Domains (6) summary
    smart00036
    Location:1620 → 1916
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:97 → 360
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    COG1196
    Location:474 → 1320
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00029
    Location:1390 → 1438
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd05601
    Location:95 → 422
    STKc_CRIK; Catalytic domain of the Serine/Threonine Kinase, Citron Rho-interacting kinase
    pfam00169
    Location:1471 → 1590
    PH; PH domain

  6. XM_017018736.2 → XP_016874225.1  citron Rho-interacting kinase isoform X5

  7. XM_011537785.2 → XP_011536087.1  citron Rho-interacting kinase isoform X3

    Conserved Domains (6) summary
    smart00036
    Location:1635 → 1931
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:97 → 360
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    COG1196
    Location:474 → 1320
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00029
    Location:1390 → 1438
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd05601
    Location:95 → 422
    STKc_CRIK; Catalytic domain of the Serine/Threonine Kinase, Citron Rho-interacting kinase
    pfam00169
    Location:1471 → 1590
    PH; PH domain

  8. XM_017018735.2 → XP_016874224.1  citron Rho-interacting kinase isoform X4

  9. XM_011537784.2 → XP_011536086.1  citron Rho-interacting kinase isoform X2

    Conserved Domains (5) summary
    smart00109
    Location:1405 → 1453
    C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
    smart00036
    Location:1650 → 1946
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00233
    Location:1486 → 1605
    PH; Pleckstrin homology domain
    COG1196
    Location:474 → 1335
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd05601
    Location:95 → 422
    STKc_CRIK; Catalytic domain of the Serine/Threonine Kinase, Citron Rho-interacting kinase

  10. XM_011537783.2 → XP_011536085.1  citron Rho-interacting kinase isoform X1

    Conserved Domains (6) summary
    smart00036
    Location:1650 → 1946
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:97 → 360
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    COG1196
    Location:474 → 1335
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00029
    Location:1405 → 1453
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd05601
    Location:95 → 422
    STKc_CRIK; Catalytic domain of the Serine/Threonine Kinase, Citron Rho-interacting kinase
    pfam00169
    Location:1486 → 1605
    PH; PH domain

  11. XM_011537790.2 → XP_011536092.1  citron Rho-interacting kinase isoform X11

    See identical proteins and their annotated locations for XP_011536092.1

    UniProtKB/TrEMBL
    A0A7I2V692
    Conserved Domains (9) summary
    smart00036
    Location:1204 → 1500
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00233
    Location:1040 → 1159
    PH; Pleckstrin homology domain
    COG4942
    Location:679 → 961
    EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
    PRK03918
    Location:2 → 641
    PRK03918; chromosome segregation protein; Provisional
    cd00029
    Location:959 → 1007
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    pfam00169
    Location:1040 → 1159
    PH; PH domain
    pfam00836
    Location:231 → 319
    Stathmin; Stathmin family
    pfam09311
    Location:462 → 743
    Rab5-bind; Rabaptin-like protein
    cl00788
    Location:188 → 253
    MttA_Hcf106; mttA/Hcf106 family

  12. XM_011537789.2 → XP_011536091.1  citron Rho-interacting kinase isoform X11

    See identical proteins and their annotated locations for XP_011536091.1

    UniProtKB/TrEMBL
    A0A7I2V692
    Related
    ENSP00000504849.1, ENST00000678652.1
    Conserved Domains (9) summary
    smart00036
    Location:1204 → 1500
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00233
    Location:1040 → 1159
    PH; Pleckstrin homology domain
    COG4942
    Location:679 → 961
    EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
    PRK03918
    Location:2 → 641
    PRK03918; chromosome segregation protein; Provisional
    cd00029
    Location:959 → 1007
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    pfam00169
    Location:1040 → 1159
    PH; PH domain
    pfam00836
    Location:231 → 319
    Stathmin; Stathmin family
    pfam09311
    Location:462 → 743
    Rab5-bind; Rabaptin-like protein
    cl00788
    Location:188 → 253
    MttA_Hcf106; mttA/Hcf106 family

  13. XM_011537791.3 → XP_011536093.1  citron Rho-interacting kinase isoform X12

    UniProtKB/TrEMBL
    A0A7I2V692
    Conserved Domains (9) summary
    smart00036
    Location:1184 → 1480
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00233
    Location:1020 → 1139
    PH; Pleckstrin homology domain
    COG4942
    Location:659 → 941
    EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
    PRK03918
    Location:12 → 578
    PRK03918; chromosome segregation protein; Provisional
    cd00029
    Location:939 → 987
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    pfam00169
    Location:1020 → 1139
    PH; PH domain
    pfam00836
    Location:211 → 299
    Stathmin; Stathmin family
    pfam09311
    Location:442 → 723
    Rab5-bind; Rabaptin-like protein
    cl00788
    Location:168 → 233
    MttA_Hcf106; mttA/Hcf106 family

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    119673075..119864647 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054370857.1 → XP_054226832.1  citron Rho-interacting kinase isoform X10

  2. XM_054370856.1 → XP_054226831.1  citron Rho-interacting kinase isoform X9

  3. XM_054370855.1 → XP_054226830.1  citron Rho-interacting kinase isoform X8

  4. XM_054370854.1 → XP_054226829.1  citron Rho-interacting kinase isoform X7

  5. XM_054370853.1 → XP_054226828.1  citron Rho-interacting kinase isoform X6

  6. XM_054370852.1 → XP_054226827.1  citron Rho-interacting kinase isoform X5

  7. XM_054370850.1 → XP_054226825.1  citron Rho-interacting kinase isoform X3

  8. XM_054370851.1 → XP_054226826.1  citron Rho-interacting kinase isoform X4

  9. XM_054370849.1 → XP_054226824.1  citron Rho-interacting kinase isoform X2

  10. XM_054370848.1 → XP_054226823.1  citron Rho-interacting kinase isoform X1

  11. XM_054370859.1 → XP_054226834.1  citron Rho-interacting kinase isoform X11

  12. XM_054370858.1 → XP_054226833.1  citron Rho-interacting kinase isoform X11

  13. XM_054370860.1 → XP_054226835.1  citron Rho-interacting kinase isoform X12

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O14578.2 GenPept UniProtKB/Swiss-Prot:O14578

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