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ncam2 neural cell adhesion molecule 2 [ Danio rerio (zebrafish) ]

Gene ID: 114441, updated on 18-Sep-2024

Summary

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Official Symbol
ncam2provided by ZNC
Official Full Name
neural cell adhesion molecule 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-010822-1
See related
Ensembl:ENSDARG00000017466 AllianceGenome:ZFIN:ZDB-GENE-010822-1
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zOCAM; sb:eu836
Summary
Acts upstream of or within response to hypoxia. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in neuron projection. Is expressed in brain; sensory system; and swim bladder. Orthologous to human NCAM2 (neural cell adhesion molecule 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See ncam2 in Genome Data Viewer
Location:
chromosome: 9
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (35169237..35557365, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (35360055..35748211, complement)

Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene si:dkey-192g7.3 Neighboring gene amyloid beta (A4) precursor protein b Neighboring gene zona pellucida glycoprotein 2, like 1 Neighboring gene SON DNA and RNA binding protein a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Ncam1a and Ncam1b: two carriers of polysialic acid with different functions in the developing zebrafish nervous system. Langhauser M, et al. Glycobiology, 2012 Feb. PMID 21890892
  2. A panel of recombinant monoclonal antibodies against zebrafish neural receptors and secreted proteins suitable for wholemount immunostaining. Staudt N, et al. Biochem Biophys Res Commun, 2015 Jan 2. PMID 25490391, Free PMC Article
  3. Nlcam modulates midline convergence during anterior neural plate morphogenesis. Brown KE, et al. Dev Biol, 2010 Mar 1. PMID 20005219
  4. Novel Genes Critical for Hypoxic Preconditioning in Zebrafish Are Regulators of Insulin and Glucose Metabolism. Manchenkov T, et al. G3 (Bethesda), 2015 Apr 3. PMID 25840431, Free PMC Article
  5. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Process Evidence Code Pubs
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within response to hypoxia IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
neural cell adhesion molecule 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_131830.2 → NP_571905.1  neural cell adhesion molecule 2 precursor

    See identical proteins and their annotated locations for NP_571905.1

    Status: PROVISIONAL

    Source sequence(s)
    AY029403
    UniProtKB/TrEMBL
    B3DGA0, Q90YM0
    Related
    ENSDARP00000091454.4, ENSDART00000100681.5
    Conserved Domains (7) summary
    cd05866
    Location:20 → 111
    Ig1_NCAM-2; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule NCAM-2
    smart00408
    Location:127 → 187
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:411 → 488
    IG_like; Immunoglobulin like
    cd00063
    Location:494 → 586
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:213 → 296
    I-set; Immunoglobulin I-set domain
    pfam00041
    Location:616 → 675
    fn3; Fibronectin type III domain
    cl11960
    Location:298 → 395
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007120.7 Reference GRCz11 Primary Assembly

    Range
    35169237..35557365 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005167807.5 → XP_005167864.1  neural cell adhesion molecule 2 isoform X1

    UniProtKB/TrEMBL
    A0A8M2BF98
    Conserved Domains (7) summary
    cd05866
    Location:20 → 111
    Ig1_NCAM-2; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule NCAM-2
    smart00408
    Location:127 → 187
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:411 → 488
    IG_like; Immunoglobulin like
    cd00063
    Location:494 → 586
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:213 → 296
    I-set; Immunoglobulin I-set domain
    pfam00041
    Location:616 → 675
    fn3; Fibronectin type III domain
    cl11960
    Location:298 → 395
    Ig; Immunoglobulin domain

  2. XM_068223276.1 → XP_068079377.1  neural cell adhesion molecule 2 isoform X2

  3. XM_005167809.5 → XP_005167866.1  neural cell adhesion molecule 2 isoform X3

    UniProtKB/TrEMBL
    A0A8M2BFW0
    Conserved Domains (7) summary
    cd05866
    Location:20 → 111
    Ig1_NCAM-2; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule NCAM-2
    smart00408
    Location:127 → 187
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:411 → 488
    IG_like; Immunoglobulin like
    cd00063
    Location:494 → 586
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:213 → 296
    I-set; Immunoglobulin I-set domain
    pfam00041
    Location:616 → 675
    fn3; Fibronectin type III domain
    cl11960
    Location:298 → 395
    Ig; Immunoglobulin domain

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394760.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    469878..597062 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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