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mafa MAF bZIP transcription factor a [ Danio rerio (zebrafish) ]

Gene ID: 114467, updated on 2-Nov-2024

Summary

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Official Symbol
mafaprovided by ZNC
Official Full Name
MAF bZIP transcription factor aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-010605-2
See related
Ensembl:ENSDARG00000015890 AllianceGenome:ZFIN:ZDB-GENE-010605-2
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
maf; c-Maf; Z-cmaf; fl13d12; wu:fl13d12
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of DNA-templated transcription. Predicted to be active in nucleus. Is expressed in brain; pronephric mesoderm; pronephric proximal convoluted tubule; pronephric proximal straight tubule; and solid lens vesicle. Human ortholog(s) of this gene implicated in Ayme-Gripp syndrome; cataract; and cataract 21 multiple types. Orthologous to human MAF (MAF bZIP transcription factor). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See mafa in Genome Data Viewer
Location:
chromosome: 18
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 18 NC_007129.7 (29402611..29589340)
105 previous assembly GRCz10 (GCF_000002035.5) 18 NC_007129.6 (29423918..29435605)

Chromosome 18 - NC_007129.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137488292 Neighboring gene uncharacterized LOC137488293 Neighboring gene PPFIA binding protein 2a Neighboring gene uncharacterized LOC137488233 Neighboring gene C-x(9)-C motif containing 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Functional Urate-Associated Genetic Variants Influence Expression of lincRNAs LINC01229 and MAFTRR. Leask M, et al. Front Genet, 2018. PMID 30719032, Free PMC Article
  2. Mouse MafA, homologue of zebrafish somite Maf 1, contributes to the specific transcriptional activity through the insulin promoter. Kajihara M, et al. Biochem Biophys Res Commun, 2003 Dec 19. PMID 14680841
  3. Recruitment of Rod Photoreceptors from Short-Wavelength-Sensitive Cones during the Evolution of Nocturnal Vision in Mammals. Kim JW, et al. Dev Cell, 2016 Jun 20. PMID 27326930, Free PMC Article
  4. Phylogenomic analysis and expression patterns of large Maf genes in Xenopus tropicalis provide new insights into the functional evolution of the gene family in osteichthyans. Coolen M, et al. Dev Genes Evol, 2005 Jul. PMID 15759153
  5. β-Cell pre-mir-21 induces dysfunction and loss of cellular identity by targeting transforming growth factor beta 2 (Tgfb2) and Smad family member 2 (Smad2) mRNAs. Ibrahim S, et al. Mol Metab, 2021 Nov. PMID 34246804, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
transcription factor Maf
Names
proto-oncogene c-maf
v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog a (paralog a)
v-maf musculoaponeurotic fibrosarcoma oncogene homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_131844.2 → NP_571919.2  transcription factor Maf

    Status: VALIDATED

    Source sequence(s)
    BC065941, EH583521
    UniProtKB/TrEMBL
    A0A8M1PD50, Q6NZW9
    Related
    ENSDARP00000108952.2, ENSDART00000014703.7
    Conserved Domains (2) summary
    cd14718
    Location:234 → 302
    bZIP_Maf_large; Basic leucine zipper (bZIP) domain of large musculoaponeurotic fibrosarcoma (Maf) proteins: a DNA-binding and dimerization domain
    pfam08383
    Location:86 → 119
    Maf_N; Maf N-terminal region

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007129.7 Reference GRCz11 Primary Assembly

    Range
    29402611..29589340
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021467572.2 → XP_021323247.1  transcription factor Maf isoform X1

    UniProtKB/TrEMBL
    A0A286Y8Q5, A0A8M9P0X6
    Related
    ENSDARP00000143556.1, ENSDART00000176966.2
    Conserved Domains (2) summary
    cd14718
    Location:234 → 302
    bZIP_Maf_large; Basic leucine zipper (bZIP) domain of large musculoaponeurotic fibrosarcoma (Maf) proteins: a DNA-binding and dimerization domain
    pfam08383
    Location:86 → 119
    Maf_N; Maf N-terminal region
Nucleotide Protein Strain
Heading Accession and Version

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