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MIR155HG MIR155 host gene [ Homo sapiens (human) ]

Gene ID: 114614, updated on 5-Mar-2024

Summary

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Official Symbol
MIR155HGprovided by HGNC
Official Full Name
MIR155 host geneprovided by HGNC
Primary source
HGNC:HGNC:35460
See related
Ensembl:ENSG00000234883 AllianceGenome:HGNC:35460
Gene type
ncRNA
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BIC; MIRHG2; BIC-155; miPEP155; NCRNA00172
Summary
This gene represents a microRNA host gene. The long RNA transcribed from this gene is expressed at high levels in lymphoma and may function as an oncogene. [provided by RefSeq, Dec 2017]
Expression
Biased expression in lymph node (RPKM 10.4), appendix (RPKM 8.0) and 9 other tissues See more
Orthologs
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Genomic context

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Location:
chromosome: 21
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 21 NC_000021.9 (25562145..25575168)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 21 NC_060945.1 (23919721..23932747)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (26934457..26947480)

Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372753 Neighboring gene cytochrome P450 family 2 subfamily C member 63, pseudogene Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr21:26829184-26830383 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13224 Neighboring gene uncharacterized LOC124905059 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18306 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:26890717-26891218 Neighboring gene ReSE screen-validated silencer GRCh37_chr21:26903379-26903482 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18307 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18308 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13225 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13226 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18309 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13227 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13228 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13229 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18310 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18311 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18312 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18313 Neighboring gene microRNA 155 Neighboring gene long intergenic non-protein coding RNA 515 Neighboring gene mitochondrial ribosomal protein L39 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18314

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The Single Nucleotide Polymorphisms rs4143370 and rs34904192 in MIR155HG Were Associated with Esophageal Cancer Risk in the Chinese Han Population. Jia Z, et al. Digestion, 2023. PMID 36646064
  2. Modulation of the long non-coding RNA Mir155hg by high, but not moderate, hydrostatic pressure in cartilage precursor cells. Montagne K, et al. PLoS One, 2022. PMID 36538560, Free PMC Article
  3. Lipopolysaccharide facilitates immune escape of hepatocellular carcinoma cells via m6A modification of lncRNA MIR155HG to upregulate PD-L1 expression. Peng L, et al. Cell Biol Toxicol, 2022 Dec. PMID 35438468
  4. Knockdown of long non-coding RNA MIR155HG suppresses melanoma cell proliferation, and deregulated MIR155HG in melanoma is associated with M1/M2 balance and macrophage infiltration. Liu R, et al. Cells Dev, 2022 Jun. PMID 35182814
  5. LncRNA MIR155HG functions as a ceRNA of miR-223-3p to promote cell pyroptosis in human degenerative NP cells. Yang W, et al. Clin Exp Immunol, 2022 Apr 4. PMID 35020847, Free PMC Article

See all (56) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The Single Nucleotide Polymorphisms rs4143370 and rs34904192 in MIR155HG Were Associated with Esophageal Cancer Risk in the Chinese Han Population.
    Title: The Single Nucleotide Polymorphisms rs4143370 and rs34904192 in MIR155HG Were Associated with Esophageal Cancer Risk in the Chinese Han Population.
  2. Lipopolysaccharide facilitates immune escape of hepatocellular carcinoma cells via m6A modification of lncRNA MIR155HG to upregulate PD-L1 expression.
    Title: Lipopolysaccharide facilitates immune escape of hepatocellular carcinoma cells via m6A modification of lncRNA MIR155HG to upregulate PD-L1 expression.
  3. Modulation of the long non-coding RNA Mir155hg by high, but not moderate, hydrostatic pressure in cartilage precursor cells.
    Title: Modulation of the long non-coding RNA Mir155hg by high, but not moderate, hydrostatic pressure in cartilage precursor cells.
  4. Effect of artificial skin membrane on the expression of miR-155 and miR-506-3p in patients with second-degree burns.
    Title: Effect of artificial skin membrane on the expression of miR-155 and miR-506-3p in patients with second-degree burns.
  5. A micropeptide encoded by lncRNA MIR155HG suppresses autoimmune inflammation via modulating antigen presentation.
    Title: A micropeptide encoded by lncRNA MIR155HG suppresses autoimmune inflammation via modulating antigen presentation.
  6. Knockdown of long non-coding RNA MIR155HG suppresses melanoma cell proliferation, and deregulated MIR155HG in melanoma is associated with M1/M2 balance and macrophage infiltration.
    Title: Knockdown of long non-coding RNA MIR155HG suppresses melanoma cell proliferation, and deregulated MIR155HG in melanoma is associated with M1/M2 balance and macrophage infiltration.
  7. LncRNA MIR155HG induces M2 macrophage polarization and drug resistance of colorectal cancer cells by regulating ANXA2.
    Title: LncRNA MIR155HG induces M2 macrophage polarization and drug resistance of colorectal cancer cells by regulating ANXA2.
  8. Association of MIR17HG and MIR155HG gene variants with steroid-induced osteonecrosis of the femoral head in the population of northern China.
    Title: Association of MIR17HG and MIR155HG gene variants with steroid-induced osteonecrosis of the femoral head in the population of northern China.
  9. LncRNA MIR155HG functions as a ceRNA of miR-223-3p to promote cell pyroptosis in human degenerative NP cells.
    Title: LncRNA MIR155HG functions as a ceRNA of miR-223-3p to promote cell pyroptosis in human degenerative NP cells.
  10. microRNA-155-3p delivered by M2 macrophages-derived exosomes enhances the progression of medulloblastoma through regulation of WDR82.
    Title: microRNA-155-3p delivered by M2 macrophages-derived exosomes enhances the progression of medulloblastoma through regulation of WDR82.
Submit: New GeneRIF Correction See all GeneRIFs (41)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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General gene information

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Markers

Homology

Other Names

  • B-cell receptor inducible
  • BIC transcript
  • microRNA host gene 2 (non-protein coding)

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in miRNA-mediated post-transcriptional gene silencing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of RISC complex IEA
Inferred from Electronic Annotation
more info
  

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_001458.3 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AA810953, AF402776, BG231961, CT000653
    Related
    ENST00000659862.2

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000021.9 Reference GRCh38.p14 Primary Assembly

    Range
    25562145..25575168
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060945.1 Alternate T2T-CHM13v2.0

    Range
    23919721..23932747
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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Chemical Information
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Research Materials