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Arsa arylsulfatase A [ Mus musculus (house mouse) ]

Gene ID: 11883, updated on 28-Oct-2024

Summary

Official Symbol
Arsaprovided by MGI
Official Full Name
arylsulfatase Aprovided by MGI
Primary source
MGI:MGI:88077
See related
Ensembl:ENSMUSG00000022620 AllianceGenome:MGI:88077
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ASA; As2; AS-A; As-2; TISP73
Summary
Predicted to enable arylsulfatase activity and calcium ion binding activity. Acts upstream of or within binding activity of sperm to zona pellucida. Located in plasma membrane. Is expressed in brain and genitourinary system. Used to study metachromatic leukodystrophy. Human ortholog(s) of this gene implicated in metachromatic leukodystrophy. Orthologous to human ARSA (arylsulfatase A). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Broad expression in testis adult (RPKM 87.4), lung adult (RPKM 26.7) and 24 other tissues See more
Orthologs
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Genomic context

See Arsa in Genome Data Viewer
Location:
15 E3; 15 44.94 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (89356679..89361627, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (89472476..89477424, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA C730034F03 gene Neighboring gene STARR-positive B cell enhancer ABC_E9159 Neighboring gene mitogen-activated protein kinase 8 interacting protein 2 Neighboring gene RIKEN cDNA C230037L18 gene Neighboring gene STARR-seq mESC enhancer starr_39466 Neighboring gene SH3 and multiple ankyrin repeat domains 3 Neighboring gene predicted gene 15609 Neighboring gene predicted gene, 36221

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables arylsulfatase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables arylsulfatase activity IEA
Inferred from Electronic Annotation
more info
 
enables arylsulfatase activity ISO
Inferred from Sequence Orthology
more info
 
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
 
enables calcium ion binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables cerebroside-sulfatase activity IEA
Inferred from Electronic Annotation
more info
 
enables sulfuric ester hydrolase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
Process Evidence Code Pubs
involved_in autophagy IEA
Inferred from Electronic Annotation
more info
 
involved_in autophagy ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within binding of sperm to zona pellucida IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in response to estrogen IEA
Inferred from Electronic Annotation
more info
 
involved_in response to estrogen ISO
Inferred from Sequence Orthology
more info
 
involved_in response to ethanol IEA
Inferred from Electronic Annotation
more info
 
involved_in response to ethanol ISO
Inferred from Sequence Orthology
more info
 
involved_in response to methylmercury IEA
Inferred from Electronic Annotation
more info
 
involved_in response to methylmercury ISO
Inferred from Sequence Orthology
more info
 
involved_in response to nutrient IEA
Inferred from Electronic Annotation
more info
 
involved_in response to nutrient ISO
Inferred from Sequence Orthology
more info
 
involved_in response to pH IEA
Inferred from Electronic Annotation
more info
 
involved_in response to pH ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in acrosomal vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in acrosomal vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in endosome IEA
Inferred from Electronic Annotation
more info
 
located_in endosome ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular space HDA PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in extrinsic component of external side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in extrinsic component of external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in lysosome IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
arylsulfatase A
Names
cerebroside-sulfatase
NP_033843.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009713.4NP_033843.2  arylsulfatase A precursor

    See identical proteins and their annotated locations for NP_033843.2

    Status: VALIDATED

    Source sequence(s)
    AC137513
    Consensus CDS
    CCDS27753.1
    UniProtKB/Swiss-Prot
    P50428, Q9DC66
    Related
    ENSMUSP00000127646.2, ENSMUST00000165199.8
    Conserved Domains (2) summary
    COG3119
    Location:16440
    AslA; Arylsulfatase A or related enzyme [Inorganic ion transport and metabolism]
    cl23718
    Location:19502
    ALP_like; alkaline phosphatases and sulfatases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    89356679..89361627 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)