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GPR139 G protein-coupled receptor 139 [ Homo sapiens (human) ]

Gene ID: 124274, updated on 2-Nov-2024

Summary

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Official Symbol
GPR139provided by HGNC
Official Full Name
G protein-coupled receptor 139provided by HGNC
Primary source
HGNC:HGNC:19995
See related
Ensembl:ENSG00000180269 MIM:618448; AllianceGenome:HGNC:19995
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PGR3; GPRg1
Summary
This gene encodes a member of the rhodopsin family of G-protein-coupled receptors. The encoded protein is almost exclusively expressed in the central nervous system. L-tryptophan and L-phenylalanine may act as the physiologic ligands of the encoded protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

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See GPR139 in Genome Data Viewer
Location:
16p12.3
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (20028239..20073890, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (19959033..20004824, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (20039561..20085212, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371116 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr16:19980466-19980966 Neighboring gene uncharacterized LOC105371117 Neighboring gene uncharacterized LOC124903660 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr16:20031023-20032222 Neighboring gene MPRA-validated peak2522 silencer Neighboring gene spalt like transcription factor 4 pseudogene 3 Neighboring gene uncharacterized LOC102723396

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Pharmacological characterization of novel small molecule agonists and antagonists for the orphan receptor GPR139. Pallareti L, et al. Eur J Pharmacol, 2023 Mar 15. PMID 36736525
  2. Identification and SAR of Glycine Benzamides as Potent Agonists for the GPR139 Receptor. Dvorak CA, et al. ACS Med Chem Lett, 2015 Sep 10. PMID 26396690, Free PMC Article
  3. Computer-aided discovery of aromatic l-α-amino acids as agonists of the orphan G protein-coupled receptor GPR139. Isberg V, et al. J Chem Inf Model, 2014 Jun 23. PMID 24826842
  4. Copy number variation distribution in six monozygotic twin pairs discordant for schizophrenia. Castellani CA, et al. Twin Res Hum Genet, 2014 Apr. PMID 24556202
  5. Identification of surrogate agonists and antagonists for orphan G-protein-coupled receptor GPR139. Hu LA, et al. J Biomol Screen, 2009 Aug. PMID 19525486

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Molecular cloning of GPRg1, a Gq-coupled orphan receptor that is expressed in the brain.
    Title: Molecular cloning and characterization of a novel Gq-coupled orphan receptor GPRg1 exclusively expressed in the central nervous system.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study of inattention and hyperactivity-impulsivity measured as quantitative traits.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables neuropeptide receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in neuropeptide signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
probable G-protein coupled receptor 139
Names
G protein-coupled receptor PGR3
g(q)-coupled orphan receptor GPRg1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001002911.4 → NP_001002911.1  probable G-protein coupled receptor 139 isoform 1

    See identical proteins and their annotated locations for NP_001002911.1

    Status: REVIEWED

    Source sequence(s)
    AC021089, AK291384, BC137237
    Consensus CDS
    CCDS32398.1
    UniProtKB/Swiss-Prot
    A8K5R9, Q6DWJ6, Q86SP2, Q8TDU8
    UniProtKB/TrEMBL
    A0A0I9QQP3, A0A142CHG1
    Related
    ENSP00000458791.2, ENST00000570682.2
    Conserved Domains (1) summary
    cd15919
    Location:27 → 296
    7tmA_GPR139; G-protein-coupled receptor GPR139, member of the class A family of seven-transmembrane G protein-coupled receptors

  2. NM_001318483.1 → NP_001305412.1  probable G-protein coupled receptor 139 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 2, which has a shorter N-ternimus, compared to isoform 1.
    Source sequence(s)
    AK291384, BC144547, DN693347
    UniProtKB/Swiss-Prot
    Q6DWJ6
    Conserved Domains (2) summary
    cd14964
    Location:8 → 38
    7tm_GPCRs; TM helix 3 [structural motif]
    cl28897
    Location:1 → 203
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    20028239..20073890 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    19959033..20004824 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6DWJ6.1 GenPept UniProtKB/Swiss-Prot:Q6DWJ6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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