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jag1b jagged canonical Notch ligand 1b [ Danio rerio (zebrafish) ]

Gene ID: 140423, updated on 28-Oct-2024

Summary

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Official Symbol
jag1bprovided by ZNC
Official Full Name
jagged canonical Notch ligand 1bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-011128-4
See related
Ensembl:ENSDARG00000013168 AllianceGenome:ZFIN:ZDB-GENE-011128-4
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
kmi; puc; jag3; unp1069
Summary
Predicted to enable Notch binding activity. Acts upstream of or within several processes, including exocrine pancreas development; face morphogenesis; and inner ear development. Predicted to be located in plasma membrane. Is expressed in several structures, including digestive system; endocrine system; nervous system; otic vesicle; and pharyngeal arch. Human ortholog(s) of this gene implicated in Alagille syndrome; Charcot-Marie-Tooth disease; congenital heart disease; multiple sclerosis; and tetralogy of Fallot. Orthologous to human JAG1 (jagged canonical Notch ligand 1). [provided by Alliance of Genome Resources, Oct 2024]
Orthologs
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Genomic context

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See jag1b in Genome Data Viewer
Location:
chromosome: 13
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (35339182..35390095)
105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (35213350..35264263)

Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101882067 Neighboring gene uncharacterized LOC137487338 Neighboring gene SLX4 interacting protein Neighboring gene uncharacterized LOC137487424 Neighboring gene MKKS centrosomal shuttling protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Proliferating neural progenitors in the developing CNS of zebrafish require Jagged2 and Jagged1b. Gwak JW, et al. Mol Cells, 2010 Aug. PMID 20680491
  2. Association analysis and functional follow-up identified common variants of JAG1 accounting for risk to biliary atresia. Bai MR, et al. Front Genet, 2023. PMID 37255715, Free PMC Article
  3. Multiple myeloma exploits Jagged1 and Jagged2 to promote intrinsic and bone marrow-dependent drug resistance. Colombo M, et al. Haematologica, 2020 Jul. PMID 31582544, Free PMC Article
  4. Rapid positional cloning of zebrafish mutations by linkage and homozygosity mapping using whole-genome sequencing. Obholzer N, et al. Development, 2012 Nov. PMID 23052906, Free PMC Article
  5. Jagged 1 Rescues the Duchenne Muscular Dystrophy Phenotype. Vieira NM, et al. Cell, 2015 Nov 19. PMID 26582133, Free PMC Article

See all (84) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Multiple myeloma exploits Jagged1 and Jagged2 to promote intrinsic and bone marrow-dependent drug resistance.
    Title: Multiple myeloma exploits Jagged1 and Jagged2 to promote intrinsic and bone marrow-dependent drug resistance.
  2. Notch ligands Jagged1b and Jagged2b induce duct cell lineage in the liver and pancreas of the zebrafish.
    Title: Endoderm Jagged induces liver and pancreas duct lineage in zebrafish.
  3. Results indicate that Jagged-Notch signaling is required for segregation between wt1-expressing cells and differentiated steroidogenic tissue.
    Title: Aberrant Global and Jagged-Mediated Notch Signaling Disrupts Segregation Between wt1-Expressing and Steroidogenic Tissues in Zebrafish.
  4. Expression of both jagged2 and jagged1b mRNA in the central nervous system suggested that they might be involved in control of differentiating neural progenitors.
    Title: Proliferating neural progenitors in the developing CNS of zebrafish require Jagged2 and Jagged1b.
  5. Jagged and Delta ligands are functionally redundant or required in specific combinations in many differentiation processes
    Title: Expression analysis of jagged genes in zebrafish embryos.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables Notch binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables Notch binding IEA
Inferred from Electronic Annotation
more info
  
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within Notch signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in animal organ development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within auditory receptor cell development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cartilage development involved in endochondral bone morphogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within cartilage development involved in endochondral bone morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cell communication IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cranial skeletal system development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within cranial skeletal system development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within dorsal/ventral pattern formation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within dorsal/ventral pattern formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within exocrine pancreas development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within face morphogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within face morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within fin regeneration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within inner ear morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within intrahepatic bile duct development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within liver development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within otolith morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within pancreas development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within semicircular canal development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within semicircular canal morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in system development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within thyroid gland development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within thyroid gland development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane NAS
Non-traceable Author Statement
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein jagged-1b
Names
jagged 1b
jagged3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_131863.2 → NP_571938.2  protein jagged-1b precursor

    Status: VALIDATED

    Source sequence(s)
    CU138575
    UniProtKB/Swiss-Prot
    Q90Y54
    UniProtKB/TrEMBL
    A0A8M1PCD3, F1R986
    Related
    ENSDARP00000008197.6, ENSDART00000019323.7
    Conserved Domains (5) summary
    smart00215
    Location:860 → 927
    VWC_out; von Willebrand factor (vWF) type C domain
    cd00054
    Location:484 → 520
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam00008
    Location:337 → 365
    EGF; EGF-like domain
    pfam01414
    Location:164 → 226
    DSL; Delta serrate ligand
    pfam07657
    Location:29 → 102
    MNNL; N terminus of Notch ligand

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007124.7 Reference GRCz11 Primary Assembly

    Range
    35339182..35390095
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q90Y54.1 GenPept UniProtKB/Swiss-Prot:Q90Y54

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