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gnat2 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2 [ Danio rerio (zebrafish) ]

Gene ID: 140429, updated on 2-Nov-2024

Summary

Official Symbol
gnat2provided by ZNC
Official Full Name
guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-011128-10
See related
Ensembl:ENSDARG00000042529 AllianceGenome:ZFIN:ZDB-GENE-011128-10
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Predicted to enable G protein-coupled receptor binding activity; G-protein beta/gamma-subunit complex binding activity; and GTPase activity. Acts upstream of or within detection of light stimulus involved in visual perception. Predicted to be part of heterotrimeric G-protein complex. Predicted to be active in cytoplasm; photoreceptor inner segment; and photoreceptor outer segment. Is expressed in head; pineal complex; and visual system. Used to study achromatopsia and cone-rod dystrophy. Human ortholog(s) of this gene implicated in achromatopsia 4 and color blindness. Orthologous to human GNAT2 (G protein subunit alpha transducin 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

See gnat2 in Genome Data Viewer
Location:
chromosome: 8
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (25225590..25235603, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (25206451..25216464, complement)

Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene G protein-coupled receptor 61 Neighboring gene guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 Neighboring gene adenosine monophosphate deaminase 2b Neighboring gene glutathione S-transferase mu, tandem duplicate 1

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

General gene information

Markers

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables G protein-coupled receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables G-protein beta/gamma-subunit complex binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables G-protein beta/gamma-subunit complex binding IEA
Inferred from Electronic Annotation
more info
 
enables GTP binding IEA
Inferred from Electronic Annotation
more info
 
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
 
enables guanyl nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of heterotrimeric G-protein complex IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in photoreceptor inner segment IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in photoreceptor outer segment IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
guanine nucleotide-binding protein G(t) subunit alpha-2
Names
GNAT3
Galpha t2
T alpha C
Tc alpha
cone transducin alpha subunit
no optokinetic response f
nof
transducin alpha (cone)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_131869.2NP_571944.1  guanine nucleotide-binding protein G(t) subunit alpha-2

    See identical proteins and their annotated locations for NP_571944.1

    Status: PROVISIONAL

    Source sequence(s)
    BC059498
    UniProtKB/TrEMBL
    F6NNY3, Q6PC25, Q90WX5
    Related
    ENSDARP00000062362.4, ENSDART00000062363.6
    Conserved Domains (2) summary
    cd00066
    Location:34348
    G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)
    smart00275
    Location:13352
    G_alpha; G protein alpha subunit

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007119.7 Reference GRCz11 Primary Assembly

    Range
    25225590..25235603 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)