casp3a caspase 3, apoptosis-related cysteine peptidase a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: casp3aprovided by ZNC
Official Full Name: caspase 3, apoptosis-related cysteine peptidase aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-011210-1
See related: Ensembl:ENSDARG00000017905 AllianceGenome:ZFIN:ZDB-GENE-011210-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: casp3; zgc:100890
Summary: Enables peptidase activity. Acts upstream of or within several processes, including cellular response to antibiotic; cellular response to retinoic acid; and regulation of collateral sprouting in absence of injury. Predicted to be part of death-inducing signaling complex. Predicted to be active in cytoplasm. Is expressed in several structures, including axis; gonad; gut; nervous system; and pericardial region. Human ortholog(s) of this gene implicated in Parkinson's disease; colon cancer; lung non-small cell carcinoma; and stomach cancer. Orthologous to human CASP3 (caspase 3). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 1

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	1	NC_007112.7 (17527378..17536307)
105	previous assembly	GRCz10 (GCF_000002035.5)	1	NC_007112.6 (16834397..16843374)

Chromosome 1 - NC_007112.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CRF-mediated cytoprotection occurs through the slow and tightly controlled apoptotic pathway.
Title: Corticotropin-releasing factor regulates caspase-3 and may protect developing zebrafish from stress-induced apoptosis.
The data show that zebrafish Casp3a exhibits a broader substrate portfolio, suggesting overlap with the functions of caspase-6 in zebrafish development
Title: Phage display and structural studies reveal plasticity in substrate specificity of caspase-3a from zebrafish.
Genetic analysis showed that Caspase-3, Caspase-9, and p38 MAPK interacted with Slit1a-Robo2 signaling.
Title: Local caspase activation interacts with Slit-Robo signaling to restrict axonal arborization.
Zebrafish gene expressions of P53, Bcl-2, Bax and caspase-3 were elevated after exposure with microcystin-LR under different ambient temperatures.
Title: Apoptotic responses of zebrafish (Danio rerio) after exposure with microcystin-LR under different ambient temperatures.
Targeted gene knockdown of TNFRSF1B in zebrafish embryos results in the induction of a caspase-8, caspase-2 and P53-dependent apoptotic program in endothelial cells that bypasses caspase-3.
Title: TNF receptors regulate vascular homeostasis in zebrafish through a caspase-8, caspase-2 and P53 apoptotic program that bypasses caspase-3.
The identification and characterization of 14 natural zebrafish caspase-3 substrates that have not yet been previously studied, is reported.
Title: Novel zebrafish caspase-3 substrates.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables cysteine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info
enables cysteine-type endopeptidase activity involved in apoptotic signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine-type endopeptidase activity involved in execution phase of apoptosis	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine-type peptidase activity	IEA Inferred from Electronic Annotation more info
enables enzyme activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables peptidase activity	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cellular response to antibiotic	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cellular response to retinoic acid	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cellular response to xenobiotic stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in erythrocyte differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in execution phase of apoptosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in keratinocyte differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuron differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of neuron apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within proteolysis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of collateral sprouting in absence of injury	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of collateral sprouting in absence of injury	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
part_of death-inducing signaling complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: caspase-3a

Names: caspase 3, apoptosis-related cysteine protease a; caspase 3a

NP_571952.1

EC 3.4.22.56

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131877.3 → NP_571952.1 caspase-3a

See identical proteins and their annotated locations for NP_571952.1

Status: PROVISIONAL

Source sequence(s)

BC078310

UniProtKB/TrEMBL

A0A2R8QUC0, B8JK21, Q98UI8

Related

ENSDARP00000006831.4, ENSDART00000005593.6

Conserved Domains (1) summary

cd00032
Location:39 → 280

CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...