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ptprsa protein tyrosine phosphatase receptor type Sa [ Danio rerio (zebrafish) ]

Gene ID: 140820, updated on 28-Oct-2024

Summary

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Official Symbol
ptprsaprovided by ZNC
Official Full Name
protein tyrosine phosphatase receptor type Saprovided by ZNC
Primary source
ZFIN:ZDB-GENE-020107-3
See related
Ensembl:ENSDARG00000059738 AllianceGenome:ZFIN:ZDB-GENE-020107-3
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
ptprs; RPTP[s]; RPTPsigma; zf-RPTP[s]
Summary
Predicted to enable protein tyrosine phosphatase activity. Acts upstream of or within olfactory bulb development. Predicted to be located in plasma membrane. Is expressed in head and nervous system. Orthologous to human PTPRS (protein tyrosine phosphatase receptor type S). [provided by Alliance of Genome Resources, Oct 2024]
Orthologs
all
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Genomic context

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See ptprsa in Genome Data Viewer
Location:
chromosome: 22
Exon count:
36
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 22 NC_007133.7 (3384022..3680915, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 22 NC_007133.6 (3368576..3747086, complement)

Chromosome 22 - NC_007133.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101882509 Neighboring gene thromboxane A2 receptor Neighboring gene major histocompatibility complex class I UMA Neighboring gene major histocompatibility complex class I ULA

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Protein tyrosine phosphatase σ regulates the synapse number of zebrafish olfactory sensory neurons. Chen X, et al. J Neurochem, 2011 Nov. PMID 21812780
  2. Characterization of lncRNAs involved in cold acclimation of zebrafish ZF4 cells. Jiang P, et al. PLoS One, 2018. PMID 29634734, Free PMC Article
  3. Differential oxidation of protein-tyrosine phosphatases during zebrafish caudal fin regeneration. Wu W, et al. Sci Rep, 2017 Aug 16. PMID 28814789, Free PMC Article
  4. Identification of transcripts potentially involved in neural tube closure using RNA sequencing. Kindt LM, et al. Genesis, 2018 Mar. PMID 29488319, Free PMC Article
  5. Identification and expression of the family of classical protein-tyrosine phosphatases in zebrafish. van Eekelen M, et al. PLoS One, 2010 Sep 3. PMID 20838449, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within dephosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within olfactory bulb development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in synaptic membrane adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
receptor-type tyrosine-protein phosphatase S
Names
protein tyrosine phosphatase, receptor type, s, a
receptor-type tyrosine-protein phosphatase sigma a
XP_021325166.1
XP_021325173.1
XP_021325178.1
XP_021325179.1
XP_021325182.1
XP_021325183.1
XP_021325187.1
XP_068072483.1
XP_068072484.1
XP_068072485.1
XP_068072486.1
XP_068072487.1
XP_068072488.1
XP_068072489.1
XP_068072490.1
XP_068072491.1
XP_068072492.1
XP_068072493.1
XP_068072494.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007133.7 Reference GRCz11 Primary Assembly

    Range
    3384022..3680915 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021469512.2 → XP_021325187.1  receptor-type tyrosine-protein phosphatase S isoform X19

    UniProtKB/TrEMBL
    A0A8M9P4K6
    Conserved Domains (7) summary
    cd05739
    Location:244 → 312
    Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    smart00060
    Location:605 → 671
    FN3; Fibronectin type 3 domain
    smart00194
    Location:1229 → 1488
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:968 → 1197
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:317 → 406
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:31 → 122
    I-set; Immunoglobulin I-set domain
    cd05738
    Location:150 → 224
    Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR

  2. XM_068216392.1 → XP_068072493.1  receptor-type tyrosine-protein phosphatase S isoform X17

  3. XM_021469507.2 → XP_021325182.1  receptor-type tyrosine-protein phosphatase S isoform X15

    UniProtKB/TrEMBL
    A0A8M9P4K2
    Conserved Domains (7) summary
    cd05739
    Location:244 → 312
    Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    smart00194
    Location:1632 → 1891
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:1371 → 1600
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:317 → 406
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:31 → 122
    I-set; Immunoglobulin I-set domain
    pfam00041
    Location:909 → 993
    fn3; Fibronectin type III domain
    cd05738
    Location:150 → 224
    Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR

  4. XM_021469508.2 → XP_021325183.1  receptor-type tyrosine-protein phosphatase S isoform X16

    UniProtKB/TrEMBL
    A0A8M9PEA7
    Conserved Domains (7) summary
    cd05739
    Location:244 → 312
    Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    smart00194
    Location:1647 → 1906
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:1386 → 1615
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:317 → 406
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:31 → 122
    I-set; Immunoglobulin I-set domain
    pfam00041
    Location:918 → 1002
    fn3; Fibronectin type III domain
    cd05738
    Location:150 → 224
    Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR

  5. XM_068216393.1 → XP_068072494.1  receptor-type tyrosine-protein phosphatase S isoform X18

  6. XM_068216382.1 → XP_068072483.1  receptor-type tyrosine-protein phosphatase S isoform X1

  7. XM_021469504.2 → XP_021325179.1  receptor-type tyrosine-protein phosphatase S isoform X14

    UniProtKB/TrEMBL
    A0A8M9PJZ6
    Conserved Domains (7) summary
    cd05739
    Location:244 → 312
    Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    smart00060
    Location:605 → 671
    FN3; Fibronectin type 3 domain
    smart00194
    Location:1251 → 1510
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:990 → 1219
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:317 → 406
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:31 → 122
    I-set; Immunoglobulin I-set domain
    cd05738
    Location:150 → 224
    Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR

  8. XM_068216391.1 → XP_068072492.1  receptor-type tyrosine-protein phosphatase S isoform X12

    Related
    ENSDARP00000118236.1, ENSDART00000145114.3

  9. XM_021469498.2 → XP_021325173.1  receptor-type tyrosine-protein phosphatase S isoform X7

    UniProtKB/TrEMBL
    A0A8M9PE98
    Related
    ENSDARP00000077743.6, ENSDART00000083308.6
    Conserved Domains (7) summary
    cd05739
    Location:244 → 312
    Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    smart00194
    Location:1654 → 1913
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:1393 → 1622
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:317 → 406
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:31 → 122
    I-set; Immunoglobulin I-set domain
    pfam00041
    Location:909 → 993
    fn3; Fibronectin type III domain
    cd05738
    Location:150 → 224
    Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR

  10. XM_021469491.2 → XP_021325166.1  receptor-type tyrosine-protein phosphatase S isoform X4

    UniProtKB/TrEMBL
    A0A8M9PS65
    Conserved Domains (7) summary
    cd05739
    Location:244 → 312
    Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    smart00194
    Location:1663 → 1922
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:1402 → 1631
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:317 → 406
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:31 → 122
    I-set; Immunoglobulin I-set domain
    pfam00041
    Location:918 → 1002
    fn3; Fibronectin type III domain
    cd05738
    Location:150 → 224
    Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR

  11. XM_021469503.2 → XP_021325178.1  receptor-type tyrosine-protein phosphatase S isoform X13

    UniProtKB/TrEMBL
    A0A8M9PEA2
    Conserved Domains (7) summary
    cd05739
    Location:248 → 316
    Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    smart00060
    Location:609 → 675
    FN3; Fibronectin type 3 domain
    smart00194
    Location:1255 → 1514
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:994 → 1223
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:321 → 410
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:31 → 122
    I-set; Immunoglobulin I-set domain
    cd05738
    Location:150 → 224
    Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR

  12. XM_068216390.1 → XP_068072491.1  receptor-type tyrosine-protein phosphatase S isoform X11

  13. XM_068216386.1 → XP_068072487.1  receptor-type tyrosine-protein phosphatase S isoform X6

  14. XM_068216389.1 → XP_068072490.1  receptor-type tyrosine-protein phosphatase S isoform X10

  15. XM_068216385.1 → XP_068072486.1  receptor-type tyrosine-protein phosphatase S isoform X5

  16. XM_068216388.1 → XP_068072489.1  receptor-type tyrosine-protein phosphatase S isoform X9

  17. XM_068216383.1 → XP_068072484.1  receptor-type tyrosine-protein phosphatase S isoform X2

  18. XM_068216387.1 → XP_068072488.1  receptor-type tyrosine-protein phosphatase S isoform X8

  19. XM_068216384.1 → XP_068072485.1  receptor-type tyrosine-protein phosphatase S isoform X3

Nucleotide Protein Strain
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