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CSNK2A2 casein kinase 2 alpha 2 [ Homo sapiens (human) ]

Gene ID: 1459, updated on 3-Nov-2024

Summary

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Official Symbol
CSNK2A2provided by HGNC
Official Full Name
casein kinase 2 alpha 2provided by HGNC
Primary source
HGNC:HGNC:2459
See related
Ensembl:ENSG00000070770 MIM:115442; AllianceGenome:HGNC:2459
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CK2A2; CSNK2A1; CK2alpha'
Summary
This gene encodes the alpha', or alpha 2, catalytic subunit of the protein kinase enzyme, casein kinase 2 (CK2). Casein kinase 2 is a serine/threonine protein kinase that phosphorylates acidic proteins such as casein. It is involved in various cellular processes, including cell cycle control, apoptosis, and circadian rhythms. This heterotetrameric kinase includes two catalytic subunits, either alpha or alpha', and two regulatory beta subunits. The closely related gene paralog encoding the alpha, or alpha 1 subunit (CSNK2A1, Gene ID: 1457) is found on chromosome 20. An intronic variant in this gene (alpha 2) may be associated with leukocyte telomere length in a South Asian population. A related transcribed pseudogene is found on chromosome 11. [provided by RefSeq, Aug 2017]
Expression
Broad expression in testis (RPKM 55.0), skin (RPKM 19.3) and 24 other tissues See more
Orthologs
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Genomic context

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See CSNK2A2 in Genome Data Viewer
Location:
16q21
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (58157907..58198106, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (63953540..63993732, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (58191811..58232010, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:58131910-58132410 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:58132411-58132911 Neighboring gene TIPIN pseudogene 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10921 Neighboring gene cilia and flagella associated protein 20 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7543 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:58162549-58163470 Neighboring gene uncharacterized LOC101927556 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:58163471-58164391 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7545 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7546 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7547 Neighboring gene RNA, 7SL, cytoplasmic 645, pseudogene Neighboring gene Sharpr-MPRA regulatory region 11051 Neighboring gene uncharacterized LOC105371293 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10923 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10924 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7548

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Effect of Simultaneous Inhibition of Protein Kinase CK2 and Thymidylate Synthase in Leukemia and Breast Cancer Cells. Wińska P, et al. Anticancer Res, 2018 Aug. PMID 30061228
  2. The catalytic subunit alpha' gene of human protein kinase CK2 (CSNK2A2): genomic organization, promoter identification and determination of Ets1 as a key regulator. Ackermann K, et al. Mol Cell Biochem, 2005 Jun. PMID 16335532
  3. CK2α causes stemness and chemotherapy resistance in liver cancer through the Hedgehog signaling pathway. Wu D, et al. Hepatobiliary Pancreat Dis Int, 2023 Aug. PMID 34548224
  4. Assignment of the human casein kinase II alpha' subunit gene (CSNK2A1) to chromosome 16p13.2-p13.3. Yang-Feng TL, et al. Genomics, 1994 Jan 1. PMID 8188223
  5. Chimeric peptides as modulators of CK2-dependent signaling: Mechanism of action and off-target effects. Zanin S, et al. Biochim Biophys Acta, 2015 Oct. PMID 25936516

See all (346) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Protein kinase CK2alpha is overexpressed in classical hodgkin lymphoma, regulates key signaling pathways, PD-L1 and may represent a new target for therapy.
    Title: Protein kinase CK2α is overexpressed in classical hodgkin lymphoma, regulates key signaling pathways, PD-L1 and may represent a new target for therapy.
  2. Protein Kinase CK2alpha', More than a Backup of CK2alpha.
    Title: Protein Kinase CK2α', More than a Backup of CK2α.
  3. Cell cycle-dependent gene networks for cell proliferation activated by nuclear CK2alpha complexes.
    Title: Cell cycle-dependent gene networks for cell proliferation activated by nuclear CK2α complexes.
  4. CSNK2A2 promotes hepatocellular carcinoma progression through activation of NF-kappaB pathway.
    Title: CSNK2A2 promotes hepatocellular carcinoma progression through activation of NF-κB pathway.
  5. CK2alpha causes stemness and chemotherapy resistance in liver cancer through the Hedgehog signaling pathway.
    Title: CK2α causes stemness and chemotherapy resistance in liver cancer through the Hedgehog signaling pathway.
  6. Casein Kinase 2alpha Augments Oxaliplatin Resistance in Colorectal Cancer Cells by Increasing ABCE1 Expression.
    Title: Casein Kinase 2α Augments Oxaliplatin Resistance in Colorectal Cancer Cells by Increasing ABCE1 Expression.
  7. Okur-Chung neurodevelopmental syndrome-linked CK2alpha variants have reduced kinase activity.
    Title: Okur-Chung neurodevelopmental syndrome-linked CK2α variants have reduced kinase activity.
  8. Multiple conformations of kinase II subunit alpha (CK2alpha) hinge region, located near the active site, were observed during the dynamics.
    Title: Conformational dynamics of human protein kinase CK2α and its effect on function and inhibition.
  9. The influence of the combined treatment on apoptosis in leukemia cells, as well as on cell-cycle progression and the levels of TS, CK2alpha and P-Ser529-p65 were determined.
    Title: Effect of Simultaneous Inhibition of Protein Kinase CK2 and Thymidylate Synthase in Leukemia and Breast Cancer Cells.
  10. CK2 is required to mediate FXR SUMOylation.
    Title: A CK2-RNF4 interplay coordinates non-canonical SUMOylation and degradation of nuclear receptor FXR.
Submit: New GeneRIF Correction See all GeneRIFs (41)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study identifies variants in casein kinase II (CSNK2A2) to be associated with leukocyte telomere length in a Punjabi Sikh diabetic cohort.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Rev rev HIV-1 Rev interacting protein, casein kinase 2 alpha prime polypeptide (CSNK2A2), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells. The interaction of Rev with CSNK2A2 is decreased by RRE PubMed
rev CK2 modulates the interaction of Rev with nucleolar phosphoprotein B23 by phosphorylating B23 PubMed
rev Rev activates CK2, an effect hypothesized to promote HIV-1 replication PubMed
rev phosphorylation of Rev is dependent on the beta subunit of CK2 PubMed
rev amino acids 35-50 of Rev are involved with electrostatic interactions with CK2 while amino acids 12-24 of Rev are involved with hydrophobic interactions PubMed
rev CK2 phosphorylates Rev on Serine 5 and Serine 8 PubMed
Vpu vpu Phosphorylation of HIV-1 Vpu by casein kinase 2 is required for Vpu-mediated degradation of CD4, regulation of HIV-1 envelope secretion and control of syncytium formation PubMed
vpu The HIV-1 Vpu protein is phosphorylated by casein kinase 2 on serine amino acids 52 and 56 PubMed
matrix gag CK2 has been shown to phosphorylate HIV-1 Matrix in vitro PubMed
retropepsin gag-pol Purified recombinant HIV-1 protease (rPR) is phosphorylated by casein kinase II, and the activity of rPR is stimulated approximately 2.9-fold as a result of this phosphorylation PubMed
reverse transcriptase gag-pol Casein kinase II phosphorylates HIV-1 RT p66 and p51 in human cells PubMed
gag-pol Phosphorylation of HIV-1 RT p66 and p51 by Casein kinase II mediates the stimulation of RNA-dependent DNA polymerase (RDDP) activity in vitro PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ43934

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AS1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine kinase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA damage response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cerebral cortex development IEA
Inferred from Electronic Annotation
more info
  
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in double-strand break repair IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in liver regeneration IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of apoptotic signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of protein targeting to mitochondrion HMP PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of chromosome separation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of chromosome separation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of mitophagy HMP PubMed 
involved_in spermatogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of PcG protein complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in acrosomal vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in chromatin IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
part_of protein kinase CK2 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of protein kinase CK2 complex ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
casein kinase II subunit alpha'
Names
CK II alpha'
casein kinase 2 alpha'
casein kinase 2, alpha prime polypeptide
NP_001887.1
XP_005255858.1
XP_016878434.1
XP_047289582.1
XP_054235601.1
XP_054235602.1
XP_054235603.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001896.4 → NP_001887.1  casein kinase II subunit alpha'

    See identical proteins and their annotated locations for NP_001887.1

    Status: REVIEWED

    Source sequence(s)
    AC009107
    Consensus CDS
    CCDS10794.1
    UniProtKB/Swiss-Prot
    P19784
    Related
    ENSP00000262506.3, ENST00000262506.8
    Conserved Domains (1) summary
    cd14132
    Location:22 → 326
    STKc_CK2_alpha; Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    58157907..58198106 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047433626.1 → XP_047289582.1  casein kinase II subunit alpha' isoform X1

    UniProtKB/Swiss-Prot
    P19784

  2. XM_005255801.4 → XP_005255858.1  casein kinase II subunit alpha' isoform X3

    See identical proteins and their annotated locations for XP_005255858.1

    UniProtKB/TrEMBL
    H3BSA1
    Conserved Domains (1) summary
    cd14132
    Location:1 → 189
    STKc_CK2_alpha; Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2

  3. XM_017022945.2 → XP_016878434.1  casein kinase II subunit alpha' isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    63953540..63993732 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054379626.1 → XP_054235601.1  casein kinase II subunit alpha' isoform X1

    UniProtKB/Swiss-Prot
    P19784

  2. XM_054379628.1 → XP_054235603.1  casein kinase II subunit alpha' isoform X3

  3. XM_054379627.1 → XP_054235602.1  casein kinase II subunit alpha' isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P19784.1 GenPept UniProtKB/Swiss-Prot:P19784

Gene LinkOut

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