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ADRA1B adrenoceptor alpha 1B [ Homo sapiens (human) ]

Gene ID: 147, updated on 4-Jan-2025

Summary

Official Symbol
ADRA1Bprovided by HGNC
Official Full Name
adrenoceptor alpha 1Bprovided by HGNC
Primary source
HGNC:HGNC:278
See related
Ensembl:ENSG00000170214 MIM:104220; AllianceGenome:HGNC:278
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ADRA1; ALPHA1BAR
Summary
Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1B-adrenergic receptor, which induces neoplastic transformation when transfected into NIH 3T3 fibroblasts and other cell lines. Thus, this normal cellular gene is identified as a protooncogene. This gene comprises 2 exons and a single large intron of at least 20 kb that interrupts the coding region. [provided by RefSeq, Jul 2008]
Expression
Biased expression in spleen (RPKM 2.0), brain (RPKM 1.2) and 10 other tissues See more
Orthologs
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Genomic context

See ADRA1B in Genome Data Viewer
Location:
5q33.3
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (159865086..159989205)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (160393464..160517778)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (159343489..159400019)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377687 Neighboring gene uncharacterized LOC105377688 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:159200044-159200558 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:159200559-159201071 Neighboring gene NANOG hESC enhancer GRCh37_chr5:159201487-159201994 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr5:159205410-159206609 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16573 Neighboring gene long intergenic non-protein coding RNA 1847 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr5:159300789-159301988 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16574 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:159343446-159344062 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:159344063-159344679 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:159355809-159356308 Neighboring gene uncharacterized LOC101927790 Neighboring gene glyceraldehyde 3 phosphate dehydrogenase pseudogene 40 Neighboring gene MPRA-validated peak5555 silencer Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:159435885-159436780 Neighboring gene uncharacterized LOC124901124 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:159455528-159455695 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr5:159469604-159470298 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr5:159470299-159470993 Neighboring gene tetratricopeptide repeat domain 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:159487609-159488120 Neighboring gene MPRA-validated peak5557 silencer Neighboring gene PWWP domain containing 2A Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr5:159507098-159508004 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:159508005-159508910 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:159513521-159513688 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23554 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23555 Neighboring gene MPRA-validated peak5558 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16575 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:159546009-159546508

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome-wide meta-analysis identifies new susceptibility loci for migraine.
EBI GWAS Catalog

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in caveola  
located_in cytoplasm PubMed 
located_in nuclear membrane PubMed 
located_in nucleus PubMed 
is_active_in plasma membrane  
located_in plasma membrane PubMed 
located_in plasma membrane  

General protein information

Preferred Names
alpha-1B adrenergic receptor
Names
adrenergic, alpha-1B-, receptor
alpha-1B adrenoceptor
alpha-1B adrenoreceptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000679.4NP_000670.1  alpha-1B adrenergic receptor

    See identical proteins and their annotated locations for NP_000670.1

    Status: REVIEWED

    Source sequence(s)
    AC011343, AC068657, BQ576306, U03865
    Consensus CDS
    CCDS4347.1
    UniProtKB/Swiss-Prot
    B0LPE1, P35368
    Related
    ENSP00000306662.3, ENST00000306675.5
    Conserved Domains (2) summary
    pfam00001
    Location:62348
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:56363
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    159865086..159989205
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047416776.1XP_047272732.1  alpha-1B adrenergic receptor isoform X1

  2. XM_011534435.2XP_011532737.1  alpha-1B adrenergic receptor isoform X1

    Conserved Domains (2) summary
    pfam00001
    Location:62384
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:57181
    7tm_4; Olfactory receptor
  3. XM_006714821.4XP_006714884.1  alpha-1B adrenergic receptor isoform X5

    Conserved Domains (2) summary
    pfam00001
    Location:62324
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:57181
    7tm_4; Olfactory receptor
  4. XM_005265819.3XP_005265876.1  alpha-1B adrenergic receptor isoform X6

    Conserved Domains (2) summary
    pfam00001
    Location:62314
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:57181
    7tm_4; Olfactory receptor
  5. XM_011534437.3XP_011532739.1  alpha-1B adrenergic receptor isoform X2

    Conserved Domains (2) summary
    pfam00001
    Location:62312
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:57181
    7tm_4; Olfactory receptor
  6. XM_005265818.4XP_005265875.1  alpha-1B adrenergic receptor isoform X4

    Conserved Domains (2) summary
    pfam00001
    Location:62318
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:57181
    7tm_4; Olfactory receptor
  7. XM_011534438.3XP_011532740.1  alpha-1B adrenergic receptor isoform X3

    Conserved Domains (2) summary
    pfam00001
    Location:62312
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:57181
    7tm_4; Olfactory receptor

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    160393464..160517778
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054351711.1XP_054207686.1  alpha-1B adrenergic receptor isoform X1

  2. XM_054351709.1XP_054207684.1  alpha-1B adrenergic receptor isoform X1

  3. XM_054351710.1XP_054207685.1  alpha-1B adrenergic receptor isoform X1

  4. XM_054351715.1XP_054207690.1  alpha-1B adrenergic receptor isoform X5

  5. XM_054351716.1XP_054207691.1  alpha-1B adrenergic receptor isoform X6

  6. XM_054351712.1XP_054207687.1  alpha-1B adrenergic receptor isoform X2

  7. XM_054351714.1XP_054207689.1  alpha-1B adrenergic receptor isoform X4

  8. XM_054351713.1XP_054207688.1  alpha-1B adrenergic receptor isoform X3

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