U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ANKRD35 ankyrin repeat domain 35 [ Homo sapiens (human) ]

Gene ID: 148741, updated on 3-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
ANKRD35provided by HGNC
Official Full Name
ankyrin repeat domain 35provided by HGNC
Primary source
HGNC:HGNC:26323
See related
Ensembl:ENSG00000198483 AllianceGenome:HGNC:26323
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Biased expression in skin (RPKM 27.5), esophagus (RPKM 8.5) and 5 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See ANKRD35 in Genome Data Viewer
Location:
1q21.1
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (145866564..145885866, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (144983377..145002686, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (145549209..145568522)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1613 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1614 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:145584188-145585387 Neighboring gene nudix hydrolase 17 Neighboring gene protein inhibitor of activated STAT 3 Neighboring gene microRNA 6736 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1264 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1265 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1266 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:145562391-145562908 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:145556249-145557232 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1267 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1268 Neighboring gene uncharacterized LOC107985593 Neighboring gene integrin subunit alpha 10

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Identifying chromosomal subpopulations based on their recombination histories advances the study of the genetic basis of phenotypic traits. Ruiz-Arenas C, et al. Genome Res, 2020 Dec. PMID 33203765, Free PMC Article
  2. The E3 ligase RBCK1 reduces the sensitivity of ccRCC to sunitinib through the ANKRD35-MITD1-ANXA1 axis. Wang Y, et al. Oncogene, 2023 Mar. PMID 36732658
  3. Microtubule-associated proteins 1 (MAP1) promote human immunodeficiency virus type I (HIV-1) intracytoplasmic routing to the nucleus. Fernandez J, et al. J Biol Chem, 2015 Feb 20. PMID 25505242, Free PMC Article
  4. Expressed sequence tag analysis of human retina for the NEIBank Project: retbindin, an abundant, novel retinal cDNA and alternative splicing of other retina-preferred gene transcripts. Wistow G, et al. Mol Vis, 2002 Jun 15. PMID 12107411
  5. SR protein kinases promote splicing of nonconsensus introns. Lipp JJ, et al. Nat Struct Mol Biol, 2015 Aug. PMID 26167880

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Identifying chromosomal subpopulations based on their recombination histories advances the study of the genetic basis of phenotypic traits.
    Title: Identifying chromosomal subpopulations based on their recombination histories advances the study of the genetic basis of phenotypic traits.
Submit: New GeneRIF Correction

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

Go to the top of the page Help

Protein interactions

Protein Gene Interaction Pubs
capsid gag The interaction of HIV-1 CA with human cellular ankyrin repeat domain 35 protein (ANKRD35) is identified by yeast two-hybrid screen PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Potential readthrough

Included gene: PIAS3

Homology

Clone Names

  • FLJ25124, MGC126667, MGC126669

General protein information

Go to the top of the page Help
Preferred Names
ankyrin repeat domain-containing protein 35

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001280799.2 → NP_001267728.1  ankyrin repeat domain-containing protein 35 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame segment in the 5' coding region, compared to variant 1. The resulting isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC243547, AK294308, DA399526, HY327286
    Consensus CDS
    CCDS72868.1
    UniProtKB/TrEMBL
    B4DFX6, F6XZD3
    Related
    ENSP00000442671.2, ENST00000544626.2
    Conserved Domains (4) summary
    cd00204
    Location:24 → 136
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:34 → 126
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:8 → 41
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:29 → 60
    ANK; ANK repeat [structural motif]

  2. NM_144698.5 → NP_653299.4  ankyrin repeat domain-containing protein 35 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC243547, AK294308, BC101618, DA399526, HY327286
    Consensus CDS
    CCDS72867.1
    UniProtKB/Swiss-Prot
    A6NEU0, B4DL62, Q3MJ10, Q8N283, Q96LS3
    Related
    ENSP00000347802.4, ENST00000355594.9
    Conserved Domains (6) summary
    COG1340
    Location:676 → 968
    COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
    cd00204
    Location:81 → 206
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam05278
    Location:803 → 950
    PEARLI-4; Arabidopsis phospholipase-like protein (PEARLI 4)
    pfam12796
    Location:58 → 150
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:24 → 74
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:53 → 84
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    145866564..145885866 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    144983377..145002686 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8N283.3 GenPept UniProtKB/Swiss-Prot:Q8N283

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools