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C1orf210 chromosome 1 open reading frame 210 [ Homo sapiens (human) ]

Gene ID: 149466, updated on 2-Nov-2024

Summary

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Official Symbol
C1orf210provided by HGNC
Official Full Name
chromosome 1 open reading frame 210provided by HGNC
Primary source
HGNC:HGNC:28755
See related
Ensembl:ENSG00000253313 MIM:620582; AllianceGenome:HGNC:28755
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TEMP
Summary
Predicted to be located in early endosome; plasma membrane; and recycling endosome. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in duodenum (RPKM 14.2), small intestine (RPKM 12.7) and 15 other tissues See more
Orthologs
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Genomic context

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See C1orf210 in Genome Data Viewer
Location:
1p34.2
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (43281877..43285857, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (43152383..43156345, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (43747548..43751252, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378685 Neighboring gene cilia and flagella associated protein 57 Neighboring gene uncharacterized LOC124904164 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:43735285-43735788 Neighboring gene transmembrane protein 125 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:43751233-43751791 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:43751792-43752349 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 777 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 915 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:43786614-43787813 Neighboring gene tyrosine kinase with immunoglobulin like and EGF like domains 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:43813871-43814842 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:43814843-43815813 Neighboring gene MPL proto-oncogene, thrombopoietin receptor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. A Novel Type III Endosome Transmembrane Protein, TEMP. Aturaliya RN, et al. Cells, 2012 Nov 5. PMID 24710541, Free PMC Article
  2. Image-based genome-wide siRNA screen identifies selective autophagy factors. Orvedahl A, et al. Nature, 2011 Dec 1. PMID 22020285, Free PMC Article
  3. Transcriptome analysis of human gastric cancer. Oh JH, et al. Mamm Genome, 2005 Dec. PMID 16341674
  4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. Lamesch P, et al. Genomics, 2007 Mar. PMID 17207965, Free PMC Article
  5. Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Huttlin EL, et al. Cell, 2021 May 27. PMID 33961781, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • MGC52423

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in early endosome IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in recycling endosome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
type III endosome membrane protein TEMP

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164829.2 → NP_001158301.1  type III endosome membrane protein TEMP

    See identical proteins and their annotated locations for NP_001158301.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC093420, AL696898, BC041633
    Consensus CDS
    CCDS481.1
    UniProtKB/Swiss-Prot
    D3DPX2, Q8IVY1
    Related
    ENSP00000429399.1, ENST00000423420.1
    Conserved Domains (1) summary
    pfam15176
    Location:21 → 97
    LRR19-TM; Leucine-rich repeat family 19 TM domain

  2. NM_182517.3 → NP_872323.1  type III endosome membrane protein TEMP

    See identical proteins and their annotated locations for NP_872323.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC093420, BC041633, BM273035, BM784450
    Consensus CDS
    CCDS481.1
    UniProtKB/Swiss-Prot
    D3DPX2, Q8IVY1
    Related
    ENSP00000430918.1, ENST00000523677.6
    Conserved Domains (1) summary
    pfam15176
    Location:21 → 97
    LRR19-TM; Leucine-rich repeat family 19 TM domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    43281877..43285857 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011540802.3 → XP_011539104.1  type III endosome membrane protein TEMP isoform X1

    See identical proteins and their annotated locations for XP_011539104.1

    UniProtKB/Swiss-Prot
    D3DPX2, Q8IVY1
    Conserved Domains (1) summary
    pfam15176
    Location:21 → 97
    LRR19-TM; Leucine-rich repeat family 19 TM domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    43152383..43156345 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054334659.1 → XP_054190634.1  type III endosome membrane protein TEMP isoform X1

    UniProtKB/Swiss-Prot
    D3DPX2, Q8IVY1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8IVY1.1 GenPept UniProtKB/Swiss-Prot:Q8IVY1

Gene LinkOut

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