U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

FBXO41 F-box protein 41 [ Homo sapiens (human) ]

Gene ID: 150726, updated on 17-Sep-2024

Summary

Go to the top of the page Help
Official Symbol
FBXO41provided by HGNC
Official Full Name
F-box protein 41provided by HGNC
Primary source
HGNC:HGNC:29409
See related
Ensembl:ENSG00000163013 MIM:609108; AllianceGenome:HGNC:29409
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FBX41
Summary
This gene encodes a member of the F-box protein family, which is characterized by an approximately 40 amino acid motif, the F-box. F-box proteins constitute one of the four subunits of the SCF ubiquitin protein ligase complex that plays a role in phosphorylation-dependent ubiquitination. F-box proteins are divided into three classes depending on the interaction substrate domain each contains in addition to the F-box motif: FBXW proteins contain WD-40 domains, FBXL proteins contain leucine-rich repeats, and FBXO proteins contain either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the FBXO class. [provided by RefSeq, Feb 2014]
Expression
Biased expression in brain (RPKM 10.6), lymph node (RPKM 3.0) and 13 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See FBXO41 in Genome Data Viewer
Location:
2p13.2
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (73254690..73284478, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (73267681..73297476, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (73481818..73511606, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11637 Neighboring gene protease associated domain containing 1 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:73460911-73461442 Neighboring gene chaperonin containing TCP1 subunit 7 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:73496386-73497329 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11640 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11641 Neighboring gene uncharacterized LOC124907840 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11642 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11643 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:73518267-73518962 Neighboring gene early growth response 4

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. F-box protein FBXO41 plays vital role in arsenic trioxide-mediated autophagic death of cancer cells. Agrawal Y, et al. Toxicol Appl Pharmacol, 2022 Apr 15. PMID 35278439
  2. Genetic analysis of the F-box only protein 41 gene in Chinese Han patients with Parkinson's disease. Liang H, et al. Parkinsonism Relat Disord, 2013 Oct. PMID 23777664
  3. F-box protein FBXO41 suppresses breast cancer growth by inducing autophagic cell death through facilitating proteasomal degradation of oncogene SKP2. Agrawal Y, et al. Int J Biochem Cell Biol, 2022 Jun. PMID 35598880
  4. Loss of the neuron-specific F-box protein FBXO41 models an ataxia-like phenotype in mice with neuronal migration defects and degeneration in the cerebellum. Mukherjee C, et al. J Neurosci, 2015 Jun 10. PMID 26063905, Free PMC Article
  5. M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFbeta-TrCP. Watanabe N, et al. Proc Natl Acad Sci U S A, 2004 Mar 30. PMID 15070733, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. F-box protein FBXO41 suppresses breast cancer growth by inducing autophagic cell death through facilitating proteasomal degradation of oncogene SKP2.
    Title: F-box protein FBXO41 suppresses breast cancer growth by inducing autophagic cell death through facilitating proteasomal degradation of oncogene SKP2.
  2. F-box protein FBXO41 plays vital role in arsenic trioxide-mediated autophagic death of cancer cells.
    Title: F-box protein FBXO41 plays vital role in arsenic trioxide-mediated autophagic death of cancer cells.
  3. This study show that FBXO41 is a critical factor, not only for neuronal migration in the cerebellum, but also for its long-term integrity.
    Title: Loss of the neuron-specific F-box protein FBXO41 models an ataxia-like phenotype in mice with neuronal migration defects and degeneration in the cerebellum.
  4. Our finding suggests that the FBXO41gene may be a non-X chromosome-related Parkinson disease risk factor
    Title: Genetic analysis of the F-box only protein 41 gene in Chinese Han patients with Parkinson's disease.
Submit: New GeneRIF Correction

Phenotypes

Go to the top of the page Help

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • FLJ37709

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
  

General protein information

Go to the top of the page Help
Preferred Names
F-box only protein 41

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033973.2 RefSeqGene

    Range
    5000..34788
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001080410.4 → NP_001073879.2  F-box only protein 41

    See identical proteins and their annotated locations for NP_001073879.2

    Status: REVIEWED

    Source sequence(s)
    AC010913
    Consensus CDS
    CCDS46337.2
    UniProtKB/Swiss-Prot
    G3V0Z7, Q2M1V8, Q8TF61
    Conserved Domains (4) summary
    PHA03307
    Location:347 → 557
    PHA03307; transcriptional regulator ICP4; Provisional
    TIGR02168
    Location:199 → 346
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    sd00034
    Location:659 → 685
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam12937
    Location:557 → 592
    F-box-like

  2. NM_001371389.2 → NP_001358318.1  F-box only protein 41

    Status: REVIEWED

    Source sequence(s)
    AC010913
    Consensus CDS
    CCDS46337.2
    UniProtKB/Swiss-Prot
    G3V0Z7, Q2M1V8, Q8TF61
    Related
    ENSP00000430968.2, ENST00000520530.3
    Conserved Domains (4) summary
    PHA03307
    Location:347 → 557
    PHA03307; transcriptional regulator ICP4; Provisional
    TIGR02168
    Location:199 → 346
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    sd00034
    Location:659 → 685
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam12937
    Location:557 → 592
    F-box-like

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    73254690..73284478 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047443458.1 → XP_047299414.1  F-box only protein 41 isoform X1

    UniProtKB/Swiss-Prot
    G3V0Z7, Q2M1V8, Q8TF61

  2. XM_047443459.1 → XP_047299415.1  F-box only protein 41 isoform X1

    UniProtKB/Swiss-Prot
    G3V0Z7, Q2M1V8, Q8TF61

  3. XM_047443460.1 → XP_047299416.1  F-box only protein 41 isoform X1

    UniProtKB/Swiss-Prot
    G3V0Z7, Q2M1V8, Q8TF61

  4. XM_005264158.4 → XP_005264215.1  F-box only protein 41 isoform X3

    Conserved Domains (2) summary
    sd00034
    Location:265 → 291
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam12937
    Location:163 → 201
    F-box-like; F-box-like

  5. XM_011532563.3 → XP_011530865.1  F-box only protein 41 isoform X2

    Conserved Domains (2) summary
    sd00034
    Location:411 → 437
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam12937
    Location:309 → 347
    F-box-like; F-box-like

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    73267681..73297476 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054340685.1 → XP_054196660.1  F-box only protein 41 isoform X1

    UniProtKB/Swiss-Prot
    G3V0Z7, Q2M1V8, Q8TF61

  2. XM_054340686.1 → XP_054196661.1  F-box only protein 41 isoform X1

    UniProtKB/Swiss-Prot
    G3V0Z7, Q2M1V8, Q8TF61

  3. XM_054340687.1 → XP_054196662.1  F-box only protein 41 isoform X1

    UniProtKB/Swiss-Prot
    G3V0Z7, Q2M1V8, Q8TF61

  4. XM_054340688.1 → XP_054196663.1  F-box only protein 41 isoform X1

    UniProtKB/Swiss-Prot
    G3V0Z7, Q2M1V8, Q8TF61

  5. XM_054340690.1 → XP_054196665.1  F-box only protein 41 isoform X3

  6. XM_054340689.1 → XP_054196664.1  F-box only protein 41 isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8TF61.5 GenPept UniProtKB/Swiss-Prot:Q8TF61

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous