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SLFN5 schlafen family member 5 [ Homo sapiens (human) ]

Gene ID: 162394, updated on 3-Nov-2024

Summary

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Official Symbol
SLFN5provided by HGNC
Official Full Name
schlafen family member 5provided by HGNC
Primary source
HGNC:HGNC:28286
See related
Ensembl:ENSG00000166750 MIM:614952; AllianceGenome:HGNC:28286
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable ATP binding activity. Predicted to be involved in cell differentiation. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in lymph node (RPKM 15.8), urinary bladder (RPKM 14.2) and 24 other tissues See more
Orthologs
all
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Genomic context

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See SLFN5 in Genome Data Viewer
Location:
17q12
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (35243072..35273655)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (36191007..36221590)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (33570091..33600674)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene solute carrier family 35 member G3 Neighboring gene Spi-C transcription factor pseudogene 2 Neighboring gene uncharacterized LOC105371932 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12060 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr17:33570506-33571134 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr17:33583732-33584931 Neighboring gene NANOG hESC enhancer GRCh37_chr17:33638706-33639207 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:33640386-33641045 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:33641707-33642365 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:33660479-33660980 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:33660981-33661480 Neighboring gene RING-box protein 2-like Neighboring gene schlafen family member 11 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12062 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12063 Neighboring gene uncharacterized LOC105371933 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12064

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Human Schlafen 5 (SLFN5) Is a Regulator of Motility and Invasiveness of Renal Cell Carcinoma Cells. Sassano A, et al. Mol Cell Biol, 2015 Aug. PMID 26012550, Free PMC Article
  2. SLFN5 promotes reversible epithelial and mesenchymal transformation in ovarian cancer. Xu QP, et al. J Ovarian Res, 2023 Feb 6. PMID 36747204, Free PMC Article
  3. Schlafen 5 suppresses human immunodeficiency virus type 1 transcription by commandeering cellular epigenetic machinery. Ding J, et al. Nucleic Acids Res, 2022 Jun 24. PMID 35687115, Free PMC Article
  4. SLFN5 Regulates LAT1-Mediated mTOR Activation in Castration-Resistant Prostate Cancer. Martinez RS, et al. Cancer Res, 2021 Jul 1. PMID 33985973
  5. Role of interferon {alpha} (IFN{alpha})-inducible Schlafen-5 in regulation of anchorage-independent growth and invasion of malignant melanoma cells. Katsoulidis E, et al. J Biol Chem, 2010 Dec 17. PMID 20956525, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Schlafen 5 as a novel therapeutic target in pancreatic ductal adenocarcinoma.
    Title: Schlafen 5 as a novel therapeutic target in pancreatic ductal adenocarcinoma.
  2. SLFN5 promotes reversible epithelial and mesenchymal transformation in ovarian cancer.
    Title: SLFN5 promotes reversible epithelial and mesenchymal transformation in ovarian cancer.
  3. Schlafen 5 suppresses human immunodeficiency virus type 1 transcription by commandeering cellular epigenetic machinery.
    Title: Schlafen 5 suppresses human immunodeficiency virus type 1 transcription by commandeering cellular epigenetic machinery.
  4. SLFN5 Regulates LAT1-Mediated mTOR Activation in Castration-Resistant Prostate Cancer.
    Title: SLFN5 Regulates LAT1-Mediated mTOR Activation in Castration-Resistant Prostate Cancer.
  5. Comparative proteomics identifies Schlafen 5 (SLFN5) as a herpes simplex virus restriction factor that suppresses viral transcription.
    Title: Comparative proteomics identifies Schlafen 5 (SLFN5) as a herpes simplex virus restriction factor that suppresses viral transcription.
  6. Human Schlafen 5 regulates reversible epithelial and mesenchymal transitions in breast cancer by suppression of ZEB1 transcription.
    Title: Human Schlafen 5 regulates reversible epithelial and mesenchymal transitions in breast cancer by suppression of ZEB1 transcription.
  7. This is the first study to report that SLFN5 inhibits cancer migration and invasiveness in several common cancer cell lines by repressing MT1-MMP expression via the AKT/GSK-3beta/beta-catenin signalling pathway, suggesting that SLFN5 plays wide inhibitory roles in various cancers.
    Title: SLFN5 suppresses cancer cell migration and invasion by inhibiting MT1-MMP expression via AKT/GSK-3β/β-catenin pathway.
  8. Study results demonstrated that overexpression of SLFN5 promoted the morphology transformation of lung cancer cell line A549 from epithelial to mesenchymal, as well as migration and invasion. However, knockdown of SLFN5 resulted in the opposite results. Results suggest that SLFN5 may act as a synergist in lung cancer cell tumorigenesis and progression through beta-catenin/Snail/E-cadherin pathway.
    Title: Overexpression of SLFN5 induced the epithelial-mesenchymal transition in human lung cancer cell line A549 through β-catenin/Snail/E-cadherin pathway.
  9. Type-I IFN treatment triggers the interaction of STAT1 with SLFN5, and the resulting complex negatively controls STAT1-mediated gene transcription via interferon stimulated response elements
    Title: Human SLFN5 is a transcriptional co-repressor of STAT1-mediated interferon responses and promotes the malignant phenotype in glioblastoma.
  10. In this study population, elevated SLFN5 protein expression in patients with intestinal metaplasia correlated with progression to gastric cancer
    Title: SCHLAFEN 5 expression correlates with intestinal metaplasia that progresses to gastric cancer.
Submit: New GeneRIF Correction See all GeneRIFs (12)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Vif vif HIV-1 Vif interacts with SLFN5 PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC19764, MGC150611, MGC150612

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
schlafen family member 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001330183.2 → NP_001317112.1  schlafen family member 5 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC022706, AK303632, BQ023439
    Consensus CDS
    CCDS82106.1
    UniProtKB/TrEMBL
    B4E128
    Related
    ENSP00000440537.1, ENST00000542451.1

  2. NM_144975.4 → NP_659412.3  schlafen family member 5 isoform 1

    See identical proteins and their annotated locations for NP_659412.3

    Status: VALIDATED

    Source sequence(s)
    AC022706, BC125200, BP281007, BX102817
    Consensus CDS
    CCDS32619.1
    UniProtKB/Swiss-Prot
    Q08AF2, Q08AF3, Q8WU54, Q96A82
    UniProtKB/TrEMBL
    B4E0B1
    Related
    ENSP00000299977.3, ENST00000299977.9
    Conserved Domains (3) summary
    cl21455
    Location:574 → 657
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    cl22977
    Location:839 → 886
    UvrD_C_2; UvrD-like helicase C-terminal domain
    cl27772
    Location:34 → 332
    B3R; Poxviridae B3 protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    35243072..35273655
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    36191007..36221590
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q08AF3.1 GenPept UniProtKB/Swiss-Prot:Q08AF3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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