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vif Vif [ Human immunodeficiency virus 1 ]

Gene ID: 155459, updated on 12-Feb-2024

Summary

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Gene symbol
vif
Gene description
Vif
Locus tag
HIV1gp3
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Human immunodeficiency virus 1
Lineage
Viruses; Retro-transcribing viruses; Retroviridae; Orthoretrovirinae; Lentivirus; Primate lentivirus group
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Genomic context

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Sequence:
NC_001802.1 (4587..5165)

NC_001802.1Genomic Context describing neighboring genes Neighboring gene Gag-Pol Neighboring gene Pr55(Gag) Neighboring gene Vpr Neighboring gene Tat Neighboring gene Rev Neighboring gene Vpu Neighboring gene Envelope surface glycoprotein gp160, precursor Neighboring gene Asp

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001802.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of Clinically Relevant HIV Vif Protein Motif Mutations through Machine Learning and Undersampling. Altamirano-Flores JS, et al. Cells, 2023 Feb 28. PMID 36899908, Free PMC Article
  2. Dominant Negative Mutants of Human Immunodeficiency Virus Type 1 Viral Infectivity Factor (Vif) Disrupt Core-Binding Factor Beta-Vif Interaction. Duan S, et al. J Virol, 2022 Sep 14. PMID 35950859, Free PMC Article
  3. Host AKT-mediated phosphorylation of HIV-1 accessory protein Vif potentiates infectivity via enhanced degradation of the restriction factor APOBEC3G. Raja R, et al. J Biol Chem, 2022 Apr. PMID 35259395, Free PMC Article
  4. High-speed atomic force microscopy directly visualizes conformational dynamics of the HIV Vif protein in complex with three host proteins. Pan Y, et al. J Biol Chem, 2020 Aug 21. PMID 32587092, Free PMC Article
  5. Antagonism of PP2A is an independent and conserved function of HIV-1 Vif and causes cell cycle arrest. Marelli S, et al. Elife, 2020 Apr 15. PMID 32292164, Free PMC Article

See all (472) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Direct inhibition of human APOBEC3 deaminases by HIV-1 Vif independent of the proteolysis pathway.
    Title: Direct inhibition of human APOBEC3 deaminases by HIV-1 Vif independent of the proteolysis pathway.
  2. The structural basis for HIV-1 Vif antagonism of human APOBEC3G.
    Title: The structural basis for HIV-1 Vif antagonism of human APOBEC3G.
  3. Identification of Clinically Relevant HIV Vif Protein Motif Mutations through Machine Learning and Undersampling.
    Title: Identification of Clinically Relevant HIV Vif Protein Motif Mutations through Machine Learning and Undersampling.
  4. Dominant Negative Mutants of Human Immunodeficiency Virus Type 1 Viral Infectivity Factor (Vif) Disrupt Core-Binding Factor Beta-Vif Interaction.
    Title: Dominant Negative Mutants of Human Immunodeficiency Virus Type 1 Viral Infectivity Factor (Vif) Disrupt Core-Binding Factor Beta-Vif Interaction.
  5. HIV-1 VIF and human APOBEC3G interaction directly observed through molecular specific labeling using a new dual promotor vector.
    Title: HIV-1 VIF and human APOBEC3G interaction directly observed through molecular specific labeling using a new dual promotor vector.
  6. Host AKT-mediated phosphorylation of HIV-1 accessory protein Vif potentiates infectivity via enhanced degradation of the restriction factor APOBEC3G.
    Title: Host AKT-mediated phosphorylation of HIV-1 accessory protein Vif potentiates infectivity via enhanced degradation of the restriction factor APOBEC3G.
  7. STUB1/CHIP promotes ubiquitination and degradation of HIV-1 Vif to restore the cellular level of APOBEC3G protein.
    Title: STUB1/CHIP promotes ubiquitination and degradation of HIV-1 Vif to restore the cellular level of APOBEC3G protein.
  8. Multifaceted HIV-1 Vif interactions with human E3 ubiquitin ligase and APOBEC3s.
    Title: Multifaceted HIV-1 Vif interactions with human E3 ubiquitin ligase and APOBEC3s.
  9. Antagonism of PP2A is an independent and conserved function of HIV-1 Vif and causes cell cycle arrest.
    Title: Antagonism of PP2A is an independent and conserved function of HIV-1 Vif and causes cell cycle arrest.
  10. High-speed atomic force microscopy directly visualizes conformational dynamics of the HIV Vif protein in complex with three host proteins.
    Title: High-speed atomic force microscopy directly visualizes conformational dynamics of the HIV Vif protein in complex with three host proteins.
Submit: New GeneRIF Correction See all GeneRIFs (164)

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
ATP-binding cassette sub-family E member 1 ABCE1 associates with PubMed
ankyrin repeat and BTB/POZ domain-containing protein 2 ABTB2 upregulates PubMed
A disintegrin and metalloproteinase with thrombospondin motifs 19 ADAMTS19 downregulates PubMed
A disintegrin and metalloproteinase with thrombospondin motifs 3 preproprotein ADAMTS3 upregulates PubMed
gamma-adducin isoform b ADD3 downregulates PubMed
aryl hydrocarbon receptor AHR interacts with PubMed
alpha-hemoglobin-stabilizing protein AHSP upregulates PubMed
single-stranded DNA cytosine deaminase isoform 1 AICDA inhibits PubMed
apoptosis-inducing factor 1, mitochondrial isoform AIF precursor AIFM1 interacts with PubMed
A-kinase anchor protein 8-like isoform 1 AKAP8L interacts with PubMed
activating molecule in BECN1-regulated autophagy protein 1 isoform 2 AMBRA1 interacts with PubMed
DNA dC->dU-editing enzyme APOBEC-3A isoform a APOBEC3A relocalizes PubMed
APOBEC3A downregulates PubMed
APOBEC3A co-localizes with PubMed
DNA dC->dU-editing enzyme APOBEC-3B isoform a APOBEC3B degrades PubMed
APOBEC3B induces ubiquitination of PubMed
APOBEC3B inhibited by PubMed
APOBEC3B relocalizes PubMed
APOBEC3B co-localizes with PubMed
DNA dC->dU-editing enzyme APOBEC-3C APOBEC3C degrades PubMed
APOBEC3C degrades PubMed
APOBEC3C mediates PubMed
APOBEC3C binds PubMed
APOBEC3C interacts with PubMed
APOBEC3C interacts with PubMed
APOBEC3C downregulates PubMed
APOBEC3C degrades PubMed
APOBEC3C co-localizes with PubMed
APOBEC3C relocalizes PubMed
APOBEC3C interacts with PubMed
APOBEC3C regulates PubMed
APOBEC3C degrades PubMed
APOBEC3C degrades PubMed
APOBEC3C degrades PubMed
DNA dC->dU-editing enzyme APOBEC-3D isoform 1 APOBEC3D interacts with PubMed
APOBEC3D downregulates PubMed
APOBEC3D inhibits PubMed
APOBEC3D inhibited by PubMed
APOBEC3D degrades PubMed
APOBEC3D interacts with PubMed
APOBEC3D degrades PubMed
APOBEC3D inhibits PubMed
APOBEC3D degrades PubMed
DNA dC->dU-editing enzyme APOBEC-3F isoform a APOBEC3F binds PubMed
APOBEC3F degrades PubMed
APOBEC3F degrades PubMed
APOBEC3F binds PubMed
APOBEC3F degrades PubMed
APOBEC3F degrades PubMed
APOBEC3F mediates PubMed
APOBEC3F binds PubMed
APOBEC3F interacts with PubMed
APOBEC3F inhibits PubMed
APOBEC3F inhibits PubMed
APOBEC3F interacts with PubMed
APOBEC3F degrades PubMed
APOBEC3F disrupts PubMed
APOBEC3F binds PubMed
APOBEC3F downregulates PubMed
APOBEC3F inhibited by PubMed
APOBEC3F binds PubMed
APOBEC3F downregulates PubMed
APOBEC3F degrades PubMed
APOBEC3F binds PubMed
APOBEC3F inhibits PubMed
APOBEC3F interacts with PubMed
APOBEC3F degrades PubMed
APOBEC3F binds PubMed
APOBEC3F degrades PubMed
APOBEC3F degrades PubMed
APOBEC3F degrades PubMed
APOBEC3F interacts with PubMed
APOBEC3F interacts with PubMed
APOBEC3F interacts with PubMed
APOBEC3F inhibits PubMed
APOBEC3F inhibits PubMed
APOBEC3F interacts with PubMed
APOBEC3F co-localizes with PubMed
APOBEC3F inhibits PubMed
APOBEC3F interacts with PubMed
APOBEC3F binds PubMed
APOBEC3F degrades PubMed
APOBEC3F binds PubMed
APOBEC3F inhibits PubMed
APOBEC3F interacts with PubMed
APOBEC3F inhibits PubMed
APOBEC3F inhibits PubMed
APOBEC3F disrupts PubMed
APOBEC3F disrupts PubMed
APOBEC3F binds PubMed
APOBEC3F inhibits PubMed
APOBEC3F inhibits PubMed
DNA dC->dU-editing enzyme APOBEC-3G isoform 1 APOBEC3G interacts with PubMed
APOBEC3G binds PubMed
APOBEC3G degrades PubMed
APOBEC3G degrades PubMed
APOBEC3G antagonizes PubMed
APOBEC3G induces polyubiquitination of PubMed
APOBEC3G counteracts PubMed
APOBEC3G inhibits PubMed
APOBEC3G binds PubMed
APOBEC3G interacts with PubMed
APOBEC3G interacts with PubMed
APOBEC3G complexes with PubMed
APOBEC3G binds PubMed
APOBEC3G inhibits PubMed
APOBEC3G binds PubMed
APOBEC3G packages PubMed
APOBEC3G antagonizes PubMed
APOBEC3G degrades PubMed
APOBEC3G interacts with PubMed
APOBEC3G induces ubiquitination of PubMed
APOBEC3G inhibits PubMed
APOBEC3G inhibits PubMed
APOBEC3G degrades PubMed
APOBEC3G degrades PubMed
APOBEC3G interacts with PubMed
APOBEC3G degrades PubMed
APOBEC3G interacts with PubMed
APOBEC3G downregulates PubMed
APOBEC3G inhibits PubMed
APOBEC3G interacts with PubMed
APOBEC3G inhibits PubMed
APOBEC3G disrupts PubMed
APOBEC3G degrades PubMed
APOBEC3G interacts with PubMed
APOBEC3G degrades PubMed
APOBEC3G inhibited by PubMed
APOBEC3G interacts with PubMed
APOBEC3G interacts with PubMed
APOBEC3G degrades PubMed
APOBEC3G disrupts PubMed
APOBEC3G induces ubiquitination of PubMed
APOBEC3G interacts with PubMed
APOBEC3G inhibits PubMed
APOBEC3G downregulates PubMed
APOBEC3G interacts with PubMed
APOBEC3G degrades PubMed
APOBEC3G degrades PubMed
APOBEC3G degrades PubMed
APOBEC3G degrades PubMed
APOBEC3G degrades PubMed
APOBEC3G binds PubMed
APOBEC3G interacts with PubMed
APOBEC3G degrades PubMed
APOBEC3G degrades PubMed
APOBEC3G degrades PubMed
APOBEC3G degrades PubMed
APOBEC3G interacts with PubMed
APOBEC3G degrades PubMed
APOBEC3G interacts with PubMed
APOBEC3G degrades PubMed
APOBEC3G degrades PubMed
APOBEC3G downregulates PubMed
APOBEC3G interacts with PubMed
APOBEC3G interacts with PubMed
APOBEC3G binds PubMed
APOBEC3G degrades PubMed
APOBEC3G binds PubMed
APOBEC3G inhibits PubMed
APOBEC3G binds PubMed
APOBEC3G binds PubMed
APOBEC3G inhibits PubMed
APOBEC3G inhibits PubMed
APOBEC3G degrades PubMed
APOBEC3G degrades PubMed
APOBEC3G interacts with PubMed
APOBEC3G degrades PubMed
APOBEC3G inhibits PubMed
APOBEC3G interacts with PubMed
APOBEC3G interacts with PubMed
APOBEC3G interacts with PubMed
APOBEC3G degrades PubMed
APOBEC3G downregulates PubMed
APOBEC3G interacts with PubMed
APOBEC3G downregulates PubMed
APOBEC3G binds PubMed
APOBEC3G inhibits PubMed
APOBEC3G degrades PubMed
APOBEC3G inhibited by PubMed
APOBEC3G interacts with PubMed
APOBEC3G interacts with PubMed
APOBEC3G degrades PubMed
APOBEC3G binds PubMed
APOBEC3G binds PubMed
APOBEC3G binds PubMed
APOBEC3G degrades PubMed
APOBEC3G degrades PubMed
APOBEC3G binds PubMed
APOBEC3G inhibited by PubMed
APOBEC3G degrades PubMed
APOBEC3G degrades PubMed
APOBEC3G degrades PubMed
APOBEC3G inhibits PubMed
APOBEC3G inhibits PubMed
APOBEC3G interacts with PubMed
APOBEC3G interacts with PubMed
APOBEC3G interacts with PubMed
APOBEC3G disrupts PubMed
APOBEC3G inhibits PubMed
APOBEC3G inhibits PubMed
APOBEC3G inhibits PubMed
APOBEC3G inhibits PubMed
APOBEC3G degrades PubMed
APOBEC3G downregulates PubMed
APOBEC3G interacts with PubMed
APOBEC3G inhibits PubMed
APOBEC3G binds PubMed
APOBEC3G binds PubMed
APOBEC3G degrades PubMed
DNA dC->dU-editing enzyme APOBEC-3H isoform SV-183 APOBEC3H inhibits PubMed
APOBEC3H degrades PubMed
APOBEC3H degrades PubMed
APOBEC3H interacts with PubMed
APOBEC3H inhibits PubMed
APOBEC3H interacts with PubMed
APOBEC3H downregulates PubMed
APOBEC3H inhibited by PubMed
APOBEC3H interacts with PubMed
APOBEC3H induces ubiquitination of PubMed
APOBEC3H inhibits PubMed
APOBEC3H inhibits PubMed
APOBEC3H inhibits PubMed
APOBEC3H inhibits PubMed
APOBEC3H degrades PubMed
apolipoprotein L1 isoform a precursor APOL1 downregulated by PubMed
APOL1 downregulated by PubMed
amphiregulin preproprotein AREG upregulates PubMed
cysteine protease ATG4A isoform a ATG4A interacts with PubMed
cysteine protease ATG4B isoform a ATG4B interacts with PubMed
cysteine protease ATG4C ATG4C interacts with PubMed
cysteine protease ATG4D isoform 1 precursor ATG4D interacts with PubMed
serine-protein kinase ATM isoform a ATM downregulates PubMed
protein ATP1B4 isoform B ATP1B4 upregulates PubMed
ataxin-1 isoform ATXN1 ATXN1 upregulates PubMed
galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1 isoform 1 B3GAT1 upregulates PubMed
large proline-rich protein BAG6 isoform a BAG6 interacts with PubMed
BAG6 interacts with PubMed
bromodomain adjacent to zinc finger domain protein 2A isoform 1 BAZ2A downregulates PubMed
nuclear nucleic acid-binding protein C1D C1D modulates PubMed
complement C5 isoform 1 preproprotein C5 downregulates PubMed
CDK5 and ABL1 enzyme substrate 1 isoform 1 CABLES1 upregulates PubMed
multifunctional protein CAD isoform 1 CAD interacts with PubMed
calcium homeostasis modulator protein 6 isoform 1 CALHM6 downregulates PubMed
calcyphosin-2 isoform 1 CAPS2 downregulates PubMed
capping protein, Arp2/3 and myosin-I linker protein 2 isoform 1 CARMIL2 interacts with PubMed
cation channel sperm-associated protein 3 CATSPER3 downregulates PubMed
core-binding factor subunit beta isoform 2 CBFB requires PubMed
CBFB interacts PubMed
CBFB binds PubMed
CBFB stabilized by PubMed
CBFB interacts with PubMed
CBFB requires PubMed
CBFB interacts with PubMed
CBFB complexes with PubMed
CBFB stabilized by PubMed
CBFB interacts with PubMed
CBFB binds PubMed
CBFB complexes with PubMed
CBFB interacts with PubMed
CBFB stabilized by PubMed
CBFB disrupted by PubMed
CBFB enhanced by PubMed
CBFB binds PubMed
CBFB complexes with PubMed
CBFB binds PubMed
CBFB complexes with PubMed
CBFB interacts with PubMed
CBFB complexes with PubMed
CBFB interacts with PubMed
CBFB complexes with PubMed
CBFB binds PubMed
CBFB enhanced by PubMed
CBFB cooperates with PubMed
CBFB interacts with PubMed
CBFB complexes with PubMed
CBFB interacts with PubMed
CBFB induces ubiquitination of PubMed
CBFB binds PubMed
CBFB complexes with PubMed
CBFB complexes with PubMed
CBFB interacts with PubMed
CBFB interacts with PubMed
CBFB interacts with PubMed
CBFB interacts with PubMed
CBFB interacts with PubMed
CBFB stabilized by PubMed
CBFB interacts with PubMed
CBFB interacts with PubMed
CBFB binds PubMed
CBFB interacts with PubMed
cell cycle and apoptosis regulator protein 2 isoform 1 CCAR2 interacts with PubMed
C-C motif chemokine 1 precursor CCL1 downregulates PubMed
cyclin-A1 isoform a CCNA1 upregulates PubMed
G2/mitotic-specific cyclin-B1 isoform 1 CCNB1 inhibits PubMed
C-C chemokine receptor type 4 CCR4 upregulates PubMed
C-C chemokine receptor type 7 isoform a precursor CCR7 upregulates PubMed
C-C chemokine receptor type 9 isoform B CCR9 downregulates PubMed
T-complex protein 1 subunit beta isoform 1 CCT2 interacts with PubMed
T-complex protein 1 subunit gamma isoform a CCT3 interacts with PubMed
T-complex protein 1 subunit delta isoform a CCT4 interacts with PubMed
T-complex protein 1 subunit epsilon isoform a CCT5 interacts with PubMed
T-complex protein 1 subunit zeta isoform a CCT6A interacts with PubMed
T-complex protein 1 subunit eta isoform a CCT7 interacts with PubMed
T-complex protein 1 subunit theta isoform 1 CCT8 interacts with PubMed
vacuolar fusion protein CCZ1 homolog B CCZ1B downregulates PubMed
CD226 antigen isoform a precursor CD226 downregulates PubMed
CMRF35-like molecule 8 isoform 1 precursor CD300A downregulates PubMed
T-cell surface glycoprotein CD4 isoform 1 precursor CD4 interacts with PubMed
CD44 antigen isoform 1 precursor CD44 upregulates PubMed
ubiquitin-conjugating enzyme E2 R1 CDC34 cooperates with PubMed
cyclin-dependent kinase 1 isoform 1 CDK1 inhibits PubMed
CDK1 inhibits PubMed
cyclin-dependent kinase 9 CDK9 interacts with PubMed
threonylcarbamoyladenosine tRNA methylthiotransferase CDKAL1 interacts with PubMed
cyclin-dependent kinase inhibitor 1 isoform 1 CDKN1A upregulates PubMed
CCAAT/enhancer-binding protein beta isoform a CEBPB enhanced by PubMed
CCAAT/enhancer-binding protein epsilon CEBPE upregulates PubMed
centrosomal protein of 170 kDa isoform alpha CEP170 interacts with PubMed
C-type lectin domain family 2 member D isoform 1 CLEC2D downregulates PubMed
collectin-12 COLEC12 downregulates PubMed
complement receptor type 2 isoform 2 precursor CR2 downregulates PubMed
macrophage colony-stimulating factor 1 isoform a precursor CSF1 upregulates PubMed
granulocyte-macrophage colony-stimulating factor precursor CSF2 upregulates PubMed
cullin-2 isoform c CUL2 interacts with PubMed
cullin-4A isoform 2 CUL4A interacts with PubMed
cullin-5 CUL5 interacts with PubMed
CUL5 interacts with PubMed
CUL5 complexes with PubMed
CUL5 complexes with PubMed
CUL5 complexes with PubMed
CUL5 interacts with PubMed
CUL5 complexes with PubMed
CUL5 binds PubMed
CUL5 complexes with PubMed
CUL5 interacts with PubMed
CUL5 complexes with PubMed
CUL5 complexes with PubMed
CUL5 complexes with PubMed
CUL5 interacts with PubMed
CUL5 binds PubMed
CUL5 interacts with PubMed
CUL5 interacts with PubMed
CUL5 interacts with PubMed
CUL5 complexes with PubMed
CUL5 interacts with PubMed
CUL5 interacts with PubMed
CUL5 requires PubMed
CUL5 interacts with PubMed
CUL5 interacts with PubMed
CUL5 inhibited by PubMed
CUL5 regulated by PubMed
CUL5 interacts with PubMed
CUL5 interacts with PubMed
C-X-C chemokine receptor type 3 isoform 1 CXCR3 upregulates PubMed
cytochrome P450 3A7 CYP3A7 downregulates PubMed
CYFIP-related Rac1 interactor A CYRIA upregulates PubMed
DDB1- and CUL4-associated factor 11 isoform 1 DCAF11 interacts with PubMed
DNA damage-binding protein 1 DDB1 interacts with PubMed
7-dehydrocholesterol reductase isoform 1 DHCR7 upregulates PubMed
ATP-dependent RNA helicase A DHX9 regulated by PubMed
dnaJ homolog subfamily A member 1 isoform 1 DNAJA1 interacts with PubMed
dnaJ homolog subfamily A member 2 DNAJA2 interacts with PubMed
dnaJ homolog subfamily B member 2 isoform b DNAJB2 interacts with PubMed
dnaJ homolog subfamily C member 7 isoform 1 DNAJC7 interacts with PubMed
dual specificity protein phosphatase 1 DUSP1 upregulates PubMed
egl nine homolog 1 isoform 1 EGLN1 downregulates PubMed
interferon-induced, double-stranded RNA-activated protein kinase isoform a EIF2AK2 regulated by PubMed
eukaryotic translation initiation factor 4E type 3 isoform b EIF4E3 upregulates PubMed
elongin-B isoform a ELOB complexes with PubMed
ELOB interacts with PubMed
ELOB complexes with PubMed
ELOB complexes with PubMed
ELOB complexes with PubMed
ELOB complexes with PubMed
ELOB interacts with PubMed
ELOB complexes with PubMed
ELOB complexes with PubMed
ELOB binds PubMed
ELOB stabilized by PubMed
ELOB interacts with PubMed
ELOB interacts with PubMed
ELOB enhanced by PubMed
ELOB complexes with PubMed
ELOB binds PubMed
elongin-C isoform a ELOC complexes with PubMed
ELOC interacts with PubMed
ELOC interacts with PubMed
ELOC interacts with PubMed
ELOC complexes with PubMed
ELOC complexes with PubMed
ELOC interacts with PubMed
ELOC complexes with PubMed
ELOC interacts with PubMed
ELOC interacts with PubMed
ELOC complexes with PubMed
ELOC complexes with PubMed
ELOC binds PubMed
ELOC enhanced by PubMed
ELOC complexes with PubMed
ELOC interacts with PubMed
ELOC interacts with PubMed
ELOC complexes with PubMed
ELOC binds PubMed
GTPase Era, mitochondrial isoform 1 ERAL1 interacts with PubMed
ERBB receptor feedback inhibitor 1 ERRFI1 downregulates PubMed
proteinase-activated receptor 3 isoform 1 precursor F2RL2 downregulates PubMed
tissue factor isoform 1 precursor F3 upregulates PubMed
fatty acid synthase FASN interacts with PubMed
fibroblast growth factor-binding protein 2 precursor FGFBP2 downregulates PubMed
fibroleukin precursor FGL2 downregulates PubMed
fascin FSCN1 upregulates PubMed
trifunctional purine biosynthetic protein adenosine-3 isoform 1 GART interacts with PubMed
endothelial transcription factor GATA-2 isoform 1 GATA2 upregulates PubMed
guanylate-binding protein 4 GBP4 upregulates PubMed
guanylate-binding protein 5 isoform 1 GBP5 downregulates PubMed
GDNF family receptor alpha-1 isoform a preproprotein GFRA1 downregulates PubMed
GTPase IMAP family member 6 isoform 1 GIMAP6 downregulates PubMed
GLIPR1-like protein 1 isoform 2 precursor GLIPR1L1 downregulates PubMed
glycine receptor subunit beta isoform A precursor GLRB downregulates PubMed
G-protein coupled receptor 183 GPR183 upregulates PubMed
G-protein coupled receptor 52 GPR52 downregulates PubMed
G-protein coupled receptor 55 GPR55 upregulates PubMed
G protein pathway suppressor 2 GPS2 interacts with PubMed
GRB2-related adapter protein isoform 1 GRAP downregulates PubMed
glutathione S-transferase A4 GSTA4 downregulates PubMed
granzyme B isoform 1 preproprotein GZMB upregulates PubMed
GDH/6PGL endoplasmic bifunctional protein isoform 2 precursor H6PD downregulates PubMed
trifunctional enzyme subunit alpha, mitochondrial precursor HADHA interacts with PubMed
tyrosine-protein kinase HCK isoform a HCK interacts with PubMed
HCK inhibits PubMed
histone deacetylase 3 isoform 2 HDAC3 interacts with PubMed
histone deacetylase 6 isoform a HDAC6 interacts with PubMed
HDAC6 degradation is mediated by PubMed
HDAC6 inhibited by PubMed
HDAC6 complexes with PubMed
HDAC6 binds PubMed
HDAC6 decreased by PubMed
HLA class II histocompatibility antigen, DQ beta 1 chain isoform 1 precursor HLA-DQB1 downregulates PubMed
major histocompatibility complex, class II, DR beta 1 precursor HLA-DRB1 interacts with PubMed
heterogeneous nuclear ribonucleoproteins A2/B1 isoform A2 HNRNPA2B1 regulated by PubMed
HNRNPA2B1 regulated by PubMed
heterogeneous nuclear ribonucleoprotein F HNRNPF regulated by PubMed
HNRNPF regulated by PubMed
heterogeneous nuclear ribonucleoprotein H isoform a HNRNPH1 regulated by PubMed
HNRNPH1 regulated by PubMed
BLOC-2 complex member HPS6 HPS6 interacts with PubMed
heat shock protein HSP 90-alpha isoform 1 HSP90AA1 interacts with PubMed
heat shock 70 kDa protein 1A HSPA1A interacts with PubMed
heat shock 70 kDa protein 4 HSPA4 interacts with PubMed
heat shock cognate 71 kDa protein isoform 1 HSPA8 interacts with PubMed
heat shock protein beta-1 HSPB1 interacts with PubMed
60 kDa heat shock protein, mitochondrial HSPD1 interacts with PubMed
E3 ubiquitin-protein ligase HUWE1 HUWE1 interacts with PubMed
isoleucine--tRNA ligase, mitochondrial precursor IARS2 interacts with PubMed
islet cell autoantigen 1 isoform a ICA1 downregulates PubMed
interferon-induced protein with tetratricopeptide repeats 3 isoform a IFIT3 downregulates PubMed
interferon-induced transmembrane protein 1 IFITM1 downregulated by PubMed
interferon-induced transmembrane protein 2 IFITM2 downregulated by PubMed
interferon-induced transmembrane protein 3 IFITM3 downregulated by PubMed
IFITM3 downregulated by PubMed
interferon alpha-1/13 precursor IFNA1 inhibited by PubMed
interferon alpha-10 precursor IFNA10 inhibited by PubMed
IFNA13 inhibited by PubMed
interferon alpha-14 precursor IFNA14 inhibited by PubMed
interferon alpha-16 precursor IFNA16 inhibited by PubMed
interferon alpha-17 precursor IFNA17 inhibited by PubMed
interferon alpha-2 precursor IFNA2 inhibited by PubMed
interferon alpha-21 precursor IFNA21 inhibited by PubMed
interferon alpha-4 precursor IFNA4 inhibited by PubMed
interferon alpha-5 precursor IFNA5 inhibited by PubMed
interferon alpha-6 precursor IFNA6 inhibited by PubMed
interferon alpha-7 precursor IFNA7 inhibited by PubMed
interferon alpha-8 precursor IFNA8 inhibited by PubMed
interferon beta precursor IFNB1 inhibits PubMed
interferon gamma precursor IFNG downregulates PubMed
intraflagellar transport protein 70A IFT70A downregulates PubMed
zinc finger protein Aiolos isoform 1 IKZF3 interacts with PubMed
IKZF3 downregulates PubMed
interleukin-10 isoform 1 precursor IL10 upregulates PubMed
interleukin-23 receptor precursor IL23R upregulates PubMed
interleukin-31 receptor subunit alpha isoform 1 IL31RA modulates PubMed
interleukin-4 isoform 1 precursor IL4 upregulates PubMed
interleukin-7 receptor subunit alpha isoform 1 precursor IL7R upregulates PubMed
interleukin-9 receptor isoform 1 precursor IL9R interacts with PubMed
insulin-induced gene 1 protein isoform 1 INSIG1 upregulates PubMed
interferon regulatory factor 1 isoform 1 IRF1 downregulates PubMed
interferon regulatory factor 3 isoform 1 IRF3 induces cleavage of PubMed
IRF3 degrades PubMed
isthmin-1 precursor ISM1 upregulates PubMed
E3 ubiquitin-protein ligase Itchy homolog isoform 2 ITCH binds PubMed
integrin alpha-6 isoform b preproprotein ITGA6 downregulates PubMed
KH domain-containing, RNA-binding, signal transduction-associated protein 3 KHDRBS3 upregulates PubMed
sickle tail protein homolog isoform 1 KIAA1217 interacts with PubMed
KIAA1217 upregulates PubMed
kinesin-like protein KIF11 KIF11 interacts with PubMed
kinesin-like protein KIF26B KIF26B interacts with PubMed
Krueppel-like factor 2 KLF2 downregulates PubMed
lysine-rich nucleolar protein 1 isoform b KNOP1 downregulates PubMed
low-density lipoprotein receptor isoform 1 precursor LDLR upregulates PubMed
lipopolysaccharide-induced tumor necrosis factor-alpha factor isoform 1 LITAF upregulates PubMed
LON peptidase N-terminal domain and RING finger protein 2 isoform 1 LONRF2 downregulates PubMed
lymphocyte antigen 96 isoform 1 precursor LY96 upregulates PubMed
mastermind-like protein 2 MAML2 downregulates PubMed
mastermind-like domain-containing protein 1 isoform 2 MAMLD1 upregulates PubMed
microtubule-associated protein 1B isoform 1 MAP1B interacts with PubMed
MAP1B downregulates PubMed
microtubule-associated proteins 1A/1B light chain 3A isoform a MAP1LC3A binds PubMed
MAP1LC3A binds PubMed
MAP1LC3A interacts with PubMed
microtubule-associated proteins 1A/1B light chain 3B MAP1LC3B binds PubMed
MAP1LC3B binds PubMed
MAP1LC3B interacts with PubMed
microtubule-associated proteins 1A/1B light chain 3C MAP1LC3C binds PubMed
MAP1LC3C binds PubMed
MAP1LC3C interacts with PubMed
mitogen-activated protein kinase kinase kinase 5 MAP3K5 inhibited by PubMed
MAP3K5 inhibited by PubMed
MAP3K5 inhibited by PubMed
MAP3K5 binds PubMed
MAP3K5 binds PubMed
mitogen-activated protein kinase 1 MAPK1 phosphorylated by PubMed
mitogen-activated protein kinase 3 isoform 1 MAPK3 phosphorylated by PubMed
E3 ubiquitin-protein ligase Mdm2 isoform a MDM2 binds PubMed
MDM2 interacts with PubMed
MDM2 degraded by PubMed
MDM2 binds PubMed
MDM2 inhibits PubMed
neprilysin isoform a MME upregulates PubMed
meiosis-specific nuclear structural protein 1 MNS1 downregulates PubMed
mitochondrial peptide methionine sulfoxide reductase isoform a precursor MSRA downregulates PubMed
monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform 1 precursor MTHFD1L interacts with PubMed
methionine synthase isoform 1 MTR interacts with PubMed
mevalonate kinase isoform a MVK upregulates PubMed
nascent polypeptide-associated complex subunit alpha isoform a NACA interacts with PubMed
nuclear receptor corepressor 1 isoform 1 NCOR1 interacts with PubMed
E3 ubiquitin-protein ligase NEDD4 isoform 1 NEDD4 binds PubMed
NEDD8 NEDD8 complexes with PubMed
NEDD8 complexes with PubMed
pro-FMRFamide-related neuropeptide FF isoform 1 preproprotein NPFF upregulates PubMed
nuclear receptor subfamily 4 group A member 2 isoform a NR4A2 upregulates PubMed
nardilysin isoform a NRDC interacts with PubMed
5'-nucleotidase isoform 1 preproprotein NT5E upregulates PubMed
P2Y purinoceptor 14 P2RY14 downregulates PubMed
partitioning defective 6 homolog gamma PARD6G modulates PubMed
poly(rC)-binding protein 3 isoform 1 PCBP3 downregulates PubMed
high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform a PDE9A downregulates PubMed
p53 apoptosis effector related to PMP-22 PERP upregulates PubMed
phosphoribosylformylglycinamidine synthase PFAS interacts with PubMed
phosphatase and actin regulator 2 isoform 3 PHACTR2 downregulates PubMed
phosphatidylinositol-glycan biosynthesis class F protein isoform 1 PIGF downregulates PubMed
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 PIN1 interacts with PubMed
zinc finger protein PLAGL1 isoform 2 PLAGL1 downregulates PubMed
urokinase-type plasminogen activator isoform 1 preproprotein PLAU upregulates PubMed
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform a PLCB1 downregulates PubMed
PI-PLC X domain-containing protein 2 isoform b PLCXD2 upregulates PubMed
plectin isoform 1c PLEC relocalizes PubMed
polyamine-modulated factor 1-binding protein 1 isoform a PMFBP1 downregulates PubMed
DNA-directed RNA polymerase II subunit RPB1 POLR2A interacts with PubMed
DNA-directed RNA polymerase II subunit RPB2 isoform 1 POLR2B interacts with PubMed
peroxisome proliferator-activated receptor gamma isoform 1 PPARG downregulates PubMed
peptidyl-prolyl cis-trans isomerase A isoform 1 PPIA binds PubMed
serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform isoform 1 PPP2R5A degrades PubMed
PPP2R5A binds PubMed
PPP2R5A downregulates PubMed
5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform 1 PRKAA1 inhibited by PubMed
5'-AMP-activated protein kinase catalytic subunit alpha-2 PRKAA2 inhibited by PubMed
5'-AMP-activated protein kinase subunit beta-1 PRKAB1 inhibited by PubMed
5'-AMP-activated protein kinase subunit beta-2 PRKAB2 inhibited by PubMed
cAMP-dependent protein kinase catalytic subunit alpha isoform Calpha1 PRKACA inhibited by PubMed
cAMP-dependent protein kinase catalytic subunit beta isoform 2 PRKACB inhibited by PubMed
cAMP-dependent protein kinase catalytic subunit gamma PRKACG inhibited by PubMed
5'-AMP-activated protein kinase subunit gamma-1 isoform 1 PRKAG1 inhibited by PubMed
cAMP-dependent protein kinase type I-alpha regulatory subunit isoform a PRKAR1A inhibited by PubMed
cAMP-dependent protein kinase type I-beta regulatory subunit PRKAR1B inhibited by PubMed
cAMP-dependent protein kinase type II-alpha regulatory subunit isoform a PRKAR2A inhibited by PubMed
cAMP-dependent protein kinase type II-beta regulatory subunit PRKAR2B inhibited by PubMed
prolactin precursor PRL downregulates PubMed
prokineticin-2 isoform b precursor PROK2 upregulates PubMed
proteasome subunit alpha type-2 PSMA2 interacts with PubMed
proteasome subunit alpha type-3 isoform 1 PSMA3 interacts with PubMed
proteasome subunit alpha type-5 isoform 1 PSMA5 interacts with PubMed
proteasome subunit alpha type-6 isoform a PSMA6 interacts with PubMed
proteasome subunit alpha type-7 PSMA7 interacts with PubMed
proteasome subunit beta type-10 PSMB10 interacts with PubMed
proteasome subunit beta type-2 isoform 1 PSMB2 interacts with PubMed
proteasome subunit beta type-3 PSMB3 interacts with PubMed
proteasome subunit beta type-4 PSMB4 interacts with PubMed
proteasome subunit beta type-5 isoform 1 PSMB5 interacts with PubMed
proteasome subunit beta type-6 isoform 1 PSMB6 interacts with PubMed
proteasome subunit beta type-7 precursor PSMB7 interacts with PubMed
26S proteasome regulatory subunit 4 isoform a PSMC1 interacts with PubMed
26S proteasome regulatory subunit 7 isoform 1 PSMC2 interacts with PubMed
26S proteasome regulatory subunit 6A PSMC3 interacts with PubMed
26S proteasome regulatory subunit 6B isoform 1 PSMC4 interacts with PubMed
26S proteasome regulatory subunit 8 isoform 1 PSMC5 interacts with PubMed
26S proteasome regulatory subunit 10B PSMC6 interacts with PubMed
26S proteasome non-ATPase regulatory subunit 1 isoform 1 PSMD1 interacts with PubMed
26S proteasome non-ATPase regulatory subunit 10 isoform 1 PSMD10 interacts with PubMed
26S proteasome non-ATPase regulatory subunit 11 PSMD11 interacts with PubMed
26S proteasome non-ATPase regulatory subunit 12 isoform 1 PSMD12 interacts with PubMed
26S proteasome non-ATPase regulatory subunit 13 isoform 1 PSMD13 interacts with PubMed
26S proteasome non-ATPase regulatory subunit 2 isoform 1 PSMD2 interacts with PubMed
26S proteasome non-ATPase regulatory subunit 3 PSMD3 interacts with PubMed
26S proteasome non-ATPase regulatory subunit 4 isoform 2 PSMD4 interacts with PubMed
26S proteasome non-ATPase regulatory subunit 5 isoform 1 PSMD5 interacts with PubMed
26S proteasome non-ATPase regulatory subunit 6 isoform 2 PSMD6 interacts with PubMed
26S proteasome non-ATPase regulatory subunit 7 PSMD7 interacts with PubMed
26S proteasome non-ATPase regulatory subunit 8 PSMD8 interacts with PubMed
26S proteasome non-ATPase regulatory subunit 9 isoform 1 PSMD9 interacts with PubMed
proteasome activator complex subunit 1 isoform 1 PSME1 interacts with PubMed
proteasome activator complex subunit 2 PSME2 interacts with PubMed
proteasome activator complex subunit 3 isoform 1 PSME3 interacts with PubMed
PSME3 interacts with PubMed
proteasome activator complex subunit 4 PSME4 interacts with PubMed
proteasome inhibitor PI31 subunit isoform 1 PSMF1 interacts with PubMed
purine-rich element-binding protein gamma isoform A PURG modulates PubMed
ras-related protein Rab-7a RAB7A regulated by PubMed
V(D)J recombination-activating protein 2 RAG2 downregulates PubMed
RNA-binding protein 34 isoform 1 RBM34 downregulates PubMed
E3 ubiquitin-protein ligase RBX1 RBX1 complexes with PubMed
RBX1 interacts with PubMed
RBX1 interacts with PubMed
RBX1 complexes with PubMed
rho-related GTP-binding protein RhoU RHOU downregulates PubMed
rho-related GTP-binding protein RhoE precursor RND3 modulates PubMed
E3 ubiquitin-protein ligase RNF216 isoform a RNF216 binds PubMed
RNF216 interacts with PubMed
RNF216 binds PubMed
RNF216 binds PubMed
RING-box protein 2 isoform 1 RNF7 interacts with PubMed
RNF7 complexes with PubMed
RNF7 interacts with PubMed
RNF7 complexes with PubMed
RNF7 interacts with PubMed
nuclear receptor ROR-beta isoform 1 RORB upregulates PubMed
replication protein A 32 kDa subunit isoform 1 RPA2 inhibited by PubMed
S-adenosylmethionine-dependent nucleotide dehydratase RSAD2 isoform 1 RSAD2 downregulates PubMed
runt-related transcription factor 1 isoform AML1c RUNX1 inhibits PubMed
RUNX1 inhibits PubMed
RUNX1 regulates PubMed
RUNX1 interacts with PubMed
RUNX1 interacts with PubMed
runt-related transcription factor 2 isoform b RUNX2 inhibits PubMed
runt-related transcription factor 3 isoform 2 RUNX3 inhibits PubMed
sphingosine 1-phosphate receptor 1 S1PR1 downregulates PubMed
diamine acetyltransferase 1 SAT1 modulates PubMed
SAT1 binds PubMed
sodium channel protein type 3 subunit alpha isoform 1 SCN3A downregulates PubMed
monocarboxylate transporter 7 SLC16A6 downregulates PubMed
solute carrier family 22 member 1 isoform a SLC22A1 upregulates PubMed
mitochondrial 2-oxodicarboxylate carrier isoform 1 SLC25A21 downregulates PubMed
sodium- and chloride-dependent transporter XTRP3 isoform 1 SLC6A20 downregulates PubMed
schlafen family member 5 isoform 1 SLFN5 interacts with PubMed
slit homolog 2 protein isoform 1 precursor SLIT2 upregulates PubMed
mothers against decapentaplegic homolog 1 SMAD1 upregulates PubMed
SPARC-related modular calcium-binding protein 1 isoform 2 precursor SMOC1 upregulates PubMed
superoxide dismutase SOD2 upregulates PubMed
nuclear body protein SP140 isoform 1 SP140 binds PubMed
SP140 interacts with PubMed
SP140 binds PubMed
spondin-1 precursor SPON1 downregulates PubMed
protein sprouty homolog 1 SPRY1 upregulates PubMed
SPRY domain-containing SOCS box protein 1 SPSB1 downregulates PubMed
sequestosome-1 isoform 1 SQSTM1 interacts with PubMed
serine/arginine-rich splicing factor 4 SRSF4 regulated by PubMed
statherin isoform a precursor STATH upregulates PubMed
E3 ubiquitin-protein ligase CHIP isoform a STUB1 interacts with PubMed
taste receptor type 2 member 40 TAS2R40 downregulates PubMed
serine/threonine-protein kinase TBK1 TBK1 interacts with PubMed
F-box-like/WD repeat-containing protein TBL1XR1 isoform 1 TBL1XR1 interacts with PubMed
T-box transcription factor TBX21 TBX21 downregulates PubMed
T-complex protein 1 subunit alpha isoform a TCP1 interacts with PubMed
transferrin receptor protein 1 isoform 1 TFRC interacts with PubMed
transducin-like enhancer protein 1 isoform 2 TLE1 upregulates PubMed
toll-like receptor 5 precursor TLR5 downregulates PubMed
protein O-mannosyl-transferase TMTC2 isoform 1 precursor TMTC2 upregulates PubMed
tumor necrosis factor receptor superfamily member 10D precursor TNFRSF10D upregulates PubMed
tumor necrosis factor receptor superfamily member 14 isoform 1 precursor TNFRSF14 downregulates PubMed
tumor necrosis factor receptor superfamily member 8 isoform 1 precursor TNFRSF8 upregulates PubMed
tumor necrosis factor ligand superfamily member 10 isoform 1 TNFSF10 downregulates PubMed
tumor necrosis factor ligand superfamily member 15 isoform VEGI-251 precursor TNFSF15 upregulates PubMed
tumor necrosis factor ligand superfamily member 8 isoform 1 TNFSF8 upregulates PubMed
cellular tumor antigen p53 isoform a TP53 stabilizes PubMed
TP53 binds PubMed
thiamin pyrophosphokinase 1 isoform a TPK1 upregulates PubMed
TNF receptor-associated factor 1 isoform a TRAF1 upregulates PubMed
TRAF3-interacting JNK-activating modulator isoform 1 TRAF3IP3 downregulates PubMed
thyrotropin-releasing hormone receptor TRHR downregulates PubMed
E3 ubiquitin-protein ligase TRIM36 isoform 1 TRIM36 downregulates PubMed
tetratricopeptide repeat protein 28 isoform 1 TTC28 downregulates PubMed
beta-taxilin TXLNB downregulates PubMed
uveal autoantigen with coiled-coil domains and ankyrin repeats isoform 1 UACA downregulates PubMed
ubiquitin-like modifier-activating enzyme 1 UBA1 dependent on PubMed
polyubiquitin-B precursor UBB inhibited by PubMed
polyubiquitin-C UBC inhibited by PubMed
ubiquitin-conjugating enzyme E2 D2 isoform 1 UBE2D2 cooperates with PubMed
NEDD8-conjugating enzyme UBE2F isoform 1 UBE2F interacts with PubMed
UBE2F interacts with PubMed
UBE2F interacts with PubMed
ubiquitin-like protein 4A UBL4A interacts with PubMed
E3 ubiquitin-protein ligase UBR2 isoform 1 UBR2 interacts with PubMed
putative mitochondrial transporter UCP3 isoform UCP3L UCP3 downregulates PubMed
UL16-binding protein 1 isoform 1 precursor ULBP1 downregulates PubMed
ULBP1 inhibits PubMed
ULBP1 inhibits PubMed
UL16-binding protein 2 preproprotein ULBP2 inhibits PubMed
ULBP2 downregulates PubMed
ULBP2 inhibits PubMed
UL16-binding protein 3 ULBP3 downregulates PubMed
ULBP3 inhibits PubMed
ULBP3 inhibits PubMed
vimentin VIM co-localizes with PubMed
WD repeat-containing protein 6 isoform 1 WDR6 interacts with PubMed
XIAP-associated factor 1 isoform 1 XAF1 downregulates PubMed
xin actin-binding repeat-containing protein 1 isoform 1 XIRP1 upregulates PubMed
X-ray repair cross-complementing protein 6 isoform 1 XRCC6 binds PubMed
xylosyltransferase 1 XYLT1 modulates PubMed
zinc finger and BTB domain-containing protein 16 isoform 1 ZBTB16 downregulates PubMed
zinc finger protein 774 ZNF774 upregulates PubMed

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Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

General protein information

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Preferred Names
Vif

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001802.1 Reference assembly

    Range
    4587..5165
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_057851.1 Vif [Human immunodeficiency virus 1]

    See identical proteins and their annotated locations for NP_057851.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P03401, P69720, P69721, P69722, P69723, P69724
    UniProtKB/TrEMBL
    A0A076PX61, A0A288CG30, A0A386YSI5, Q74086, Q77YG0, Q79095
    Conserved Domains (1) summary
    pfam00559
    Location:1 → 192
    Vif; Retroviral Vif (Viral infectivity) protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
1103299D.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Miscellaneous