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TXLNB taxilin beta [ Homo sapiens (human) ]

Gene ID: 167838, updated on 3-Nov-2024

Summary

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Official Symbol
TXLNBprovided by HGNC
Official Full Name
taxilin betaprovided by HGNC
Primary source
HGNC:HGNC:21617
See related
Ensembl:ENSG00000164440 MIM:611438; AllianceGenome:HGNC:21617
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MDP77; LST001; C6orf198; dJ522B19.2
Summary
Predicted to enable syntaxin binding activity. Located in cytoplasm. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in heart (RPKM 26.4), ovary (RPKM 5.2) and 4 other tissues See more
Orthologs
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Genomic context

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See TXLNB in Genome Data Viewer
Location:
6q24.1
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (139159162..139323950, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (140347705..140507844, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (139561198..139613135, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene epithelial cell transforming 2 like Neighboring gene RALBP1 associated Eps domain containing 1 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr6:139298793-139299367 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17601 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17602 Neighboring gene NANOG hESC enhancer GRCh37_chr6:139331747-139332499 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17603 Neighboring gene Sharpr-MPRA regulatory region 12009 Neighboring gene ABRA C-terminal like Neighboring gene Sharpr-MPRA regulatory region 5517 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:139447769-139448270 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25165 Neighboring gene Sharpr-MPRA regulatory region 4168 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17606 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17607 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25166 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:139484703-139485202 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25167 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17608 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25168 Neighboring gene hdc homolog, cell cycle regulator Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:139563281-139563806 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:139563807-139564332 Neighboring gene Sharpr-MPRA regulatory region 11439 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr6:139583345-139584544 Neighboring gene uncharacterized LOC102723690 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25169 Neighboring gene Sharpr-MPRA regulatory region 14530 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:139634569-139635306 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr6:139635307-139636044 Neighboring gene DnaJ heat shock protein family (Hsp40) member C7 pseudogene Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr6:139689956-139690774 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17609 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25171 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17610 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25172 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17611 Neighboring gene Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Muscle-specific protein MDP77 specifically promotes motor nerve regeneration in rats. Itoh S, et al. Neurosci Lett, 2004 Apr 29. PMID 15082161
  2. Regulatory expression of MDP77 protein in the skeletal and cardiac muscles. Fujimori KE, et al. FEBS Lett, 2002 Oct 9. PMID 12372618
  3. Identification and characterization of taxilin isoforms. Nogami S, et al. Biochem Biophys Res Commun, 2004 Jul 2. PMID 15184072
  4. CBFβ stabilizes HIV Vif to counteract APOBEC3 at the expense of RUNX1 target gene expression. Kim DY, et al. Mol Cell, 2013 Feb 21. PMID 23333304, Free PMC Article
  5. Mapping a dynamic innate immunity protein interaction network regulating type I interferon production. Li S, et al. Immunity, 2011 Sep 23. PMID 21903422, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  2. identification of isoforms of taxilin; interaction with syntaxin; tissue distribution [beta-taxilin, gamma-taxilin].
    Title: Identification and characterization of taxilin isoforms.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Vif vif HIV-1 Vif downregulates the expression of taxilin beta (TXLNB) in Vif-expression T cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • DKFZp451A175

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables syntaxin binding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
  

General protein information

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Preferred Names
beta-taxilin
Names
muscle-derived protein 77

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_153235.4 → NP_694967.3  beta-taxilin

    See identical proteins and their annotated locations for NP_694967.3

    Status: VALIDATED

    Source sequence(s)
    AB085905, AL158850
    Consensus CDS
    CCDS34545.1
    UniProtKB/Swiss-Prot
    Q5HYH7, Q5VTF3, Q76L25, Q86T52, Q8N3L3, Q8N3S2
    UniProtKB/TrEMBL
    B2RBM1, Q5HYK6
    Related
    ENSP00000351206.3, ENST00000358430.8
    Conserved Domains (2) summary
    pfam09728
    Location:143 → 450
    Taxilin; Myosin-like coiled-coil protein
    cl26386
    Location:519 → 683
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    139159162..139323950 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005266836.2 → XP_005266893.1  beta-taxilin isoform X1

    See identical proteins and their annotated locations for XP_005266893.1

    UniProtKB/Swiss-Prot
    Q5HYH7, Q5VTF3, Q76L25, Q86T52, Q8N3L3, Q8N3S2
    UniProtKB/TrEMBL
    B2RBM1, Q5HYK6
    Conserved Domains (2) summary
    pfam09728
    Location:143 → 450
    Taxilin; Myosin-like coiled-coil protein
    cl26386
    Location:519 → 683
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III

  2. XM_047418253.1 → XP_047274209.1  beta-taxilin isoform X1

    UniProtKB/Swiss-Prot
    Q5HYH7, Q5VTF3, Q76L25, Q86T52, Q8N3L3, Q8N3S2

  3. XM_024446341.2 → XP_024302109.1  beta-taxilin isoform X1

    UniProtKB/Swiss-Prot
    Q5HYH7, Q5VTF3, Q76L25, Q86T52, Q8N3L3, Q8N3S2
    UniProtKB/TrEMBL
    B2RBM1, Q5HYK6
    Conserved Domains (2) summary
    pfam09728
    Location:143 → 450
    Taxilin; Myosin-like coiled-coil protein
    cl26386
    Location:519 → 683
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III

  4. XM_047418252.1 → XP_047274208.1  beta-taxilin isoform X1

    UniProtKB/Swiss-Prot
    Q5HYH7, Q5VTF3, Q76L25, Q86T52, Q8N3L3, Q8N3S2

  5. XM_011535506.3 → XP_011533808.1  beta-taxilin isoform X2

    See identical proteins and their annotated locations for XP_011533808.1

    Conserved Domains (2) summary
    pfam09728
    Location:1 → 303
    Taxilin; Myosin-like coiled-coil protein
    cl19219
    Location:129 → 204
    DUF342; Protein of unknown function (DUF342)

RNA

  1. XR_007059217.1 RNA Sequence

  2. XR_007059220.1 RNA Sequence

  3. XR_007059216.1 RNA Sequence

  4. XR_007059219.1 RNA Sequence

  5. XR_007059218.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    140347705..140507844 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054354389.1 → XP_054210364.1  beta-taxilin isoform X1

  2. XM_054354390.1 → XP_054210365.1  beta-taxilin isoform X1

  3. XM_054354391.1 → XP_054210366.1  beta-taxilin isoform X2

RNA

  1. XR_008487268.1 RNA Sequence

  2. XR_008487271.1 RNA Sequence

  3. XR_008487267.1 RNA Sequence

  4. XR_008487270.1 RNA Sequence

  5. XR_008487269.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8N3L3.3 GenPept UniProtKB/Swiss-Prot:Q8N3L3

Gene LinkOut

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