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nek8 NIMA-related kinase 8 [ Danio rerio (zebrafish) ]

Gene ID: 171094, updated on 28-Oct-2024

Summary

Official Symbol
nek8provided by ZNC
Official Full Name
NIMA-related kinase 8provided by ZNC
Primary source
ZFIN:ZDB-GENE-020509-1
See related
Ensembl:ENSDARG00000045626 AllianceGenome:ZFIN:ZDB-GENE-020509-1
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Predicted to enable ATP binding activity; metal ion binding activity; and protein kinase activity. Acts upstream of or within heart looping; pronephros formation; and renal tubule development. Located in cilium. Human ortholog(s) of this gene implicated in nephronophthisis 9 and renal-hepatic-pancreatic dysplasia. Orthologous to human NEK8 (NIMA related kinase 8). [provided by Alliance of Genome Resources, Oct 2024]
Orthologs
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Genomic context

See nek8 in Genome Data Viewer
Location:
chromosome: 15
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (15479440..15514010)
105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (15543418..15577988)

Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene transfer RNA threonine (anticodon AGU) Neighboring gene transfer RNA arginine (anticodon UCU) Neighboring gene tnf receptor-associated factor 4a Neighboring gene uncharacterized LOC797963

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cilium IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cilium IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
serine/threonine-protein kinase Nek8
Names
NIMA (never in mitosis gene a)-related kinase 8
never in mitosis A-related kinase 8
nimA-related protein kinase 8
NP_620776.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_139077.2NP_620776.2  serine/threonine-protein kinase Nek8

    Status: VALIDATED

    Source sequence(s)
    CR855391
    Related
    ENSDARP00000067094.6, ENSDART00000067095.7

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007126.7 Reference GRCz11 Primary Assembly

    Range
    15479440..15514010
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394940.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    50081..80274
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)