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Bzw2 basic leucine zipper and W2 domains 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 171439, updated on 2-Nov-2024

Summary

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Official Symbol
Bzw2provided by RGD
Official Full Name
basic leucine zipper and W2 domains 2provided by RGD
Primary source
RGD:621507
See related
EnsemblRapid:ENSRNOG00000005096 AllianceGenome:RGD:621507
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Hfb2
Summary
Predicted to be involved in regulation of translational initiation. Predicted to be active in cytoplasm. Orthologous to human BZW2 (basic leucine zipper and W2 domains 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 1249.2), Muscle (RPKM 393.6) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Bzw2 in Genome Data Viewer
Location:
6q16
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (58555362..58615921, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (52828069..52888599, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (55586754..55647650, complement)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene tetraspanin 13 Neighboring gene uncharacterized LOC134479367 Neighboring gene ankyrin repeat and MYND domain containing 2 Neighboring gene non-POU domain containing, octamer-binding, pseudogene 3 Neighboring gene leucine rich repeat containing 72 Neighboring gene MYC associated factor X, pseudogene 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Identification of the novel developmentally regulated gene, Bdm2, which is highly expressed in fetal rat brain. Nishinaka N, et al. Brain Res Dev Brain Res, 2000 Mar 15. PMID 10727730
  2. E-cadherin interactome complexity and robustness resolved by quantitative proteomics. Guo Z, et al. Sci Signal, 2014 Dec 2. PMID 25468996, Free PMC Article
  3. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in regulation of translational initiation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of translational initiation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of translational initiation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
eIF5-mimic protein 1
Names
basic leucine zipper and W2 domain-containing protein 2
brain development-related molecule 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_134402.3 → NP_599229.1  eIF5-mimic protein 1

    See identical proteins and their annotated locations for NP_599229.1

    Status: PROVISIONAL

    Source sequence(s)
    BC063149
    UniProtKB/Swiss-Prot
    Q9WTT7
    UniProtKB/TrEMBL
    A0A8I5ZSL9, A6HBA9
    Related
    ENSRNOP00000007414.2, ENSRNOT00000007414.5
    Conserved Domains (1) summary
    cd11560
    Location:218 → 408
    W2_eIF5C_like; C-terminal W2 domain of the eukaryotic translation initiation factor 5C and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    58555362..58615921 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063261524.1 → XP_063117594.1  eIF5-mimic protein 1 isoform X1

  2. XM_063261525.1 → XP_063117595.1  eIF5-mimic protein 1 isoform X2

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9WTT7.1 GenPept UniProtKB/Swiss-Prot:Q9WTT7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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