rnp-8 RRM domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: rnp-8
Official Full Name: RRM domain-containing protein
Primary source: WormBase:WBGene00020091
Locus tag: CELE_R119.7
See related: AllianceGenome:WB:WBGene00020091
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables enzyme binding activity; poly(G) binding activity; and polynucleotide adenylyltransferase activator activity. Predicted to be involved in regulation of alternative mRNA splicing, via spliceosome. Part of protein-containing complex. Is expressed in germ line and oocyte. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See rnp-8 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 6

Sequence:: Chromosome: I; NC_003279.8 (364510..368579)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data suggest that the GLD-2/RNP-8 enzyme is a broad-spectrum regulator of the oogenesis program that acts within an RNA regulatory network to specify and produce fully functional oocytes.
Title: GLD-2/RNP-8 cytoplasmic poly(A) polymerase is a broad-spectrum regulator of the oogenesis program.
In C. elegans hermaphrodites, gamete production begins with spermatogenesis and transitions later to oogenesis; the combinatorial use of GLD-2 contributes to this transition, as GLD-2/GLD-3 promotes spermatogenesis, and GLD-2/RNP-8 specifies oogenesis.
Title: Antagonism between GLD-2 binding partners controls gamete sex.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

R119.1 (e-PCR)
- UniSTS:311613

R119.7 (e-PCR)
- UniSTS:311614

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables poly(G) binding	IDA Inferred from Direct Assay more info	PubMed
enables polynucleotide adenylyltransferase activator activity	IDA Inferred from Direct Assay more info	PubMed
enables single-stranded RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables single-stranded RNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in regulation of alternative mRNA splicing, via spliceosome	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: RRM domain-containing protein

NP_001380158.1

Confirmed by transcript evidence

NP_490724.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

364510..368579

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_058323.5 → NP_490724.1 RRM domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_490724.1

Status: REVIEWED

UniProtKB/TrEMBL

O61711

Conserved Domains (2) summary

COG0724
Location:1 → 140

RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

cd00590
Location:13 → 79

RRM_SF; RNA recognition motif (RRM) superfamily
NM_001393194.1 → NP_001380158.1 RRM domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

V6CLS0