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smg-1 Serine/threonine-protein kinase smg-1 [ Caenorhabditis elegans ]

Gene ID: 172418, updated on 2-Nov-2024

Summary

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Official Symbol
smg-1
Official Full Name
Serine/threonine-protein kinase smg-1
Primary source
WormBase:WBGene00004879
Locus tag
CELE_C48B6.6
See related
AllianceGenome:WB:WBGene00004879
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable protein serine/threonine kinase activity. Involved in male genitalia development and nuclear-transcribed mRNA catabolic process, nonsense-mediated decay. Predicted to be part of TOR complex. Predicted to be active in cytoplasm and nucleus. Orthologous to human SMG1 (SMG1 nonsense mediated mRNA decay associated PI3K related kinase). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See smg-1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
42
Sequence:
Chromosome: I; NC_003279.8 (6900949..6913579, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Serpentine receptor class beta-15 Neighboring gene Essential protein Yae1 N-terminal domain-containing protein Neighboring gene U3 small nucleolar ribonucleoprotein imp3

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Spatial and temporal patterns of lin-12 expression during C. elegans hermaphrodite development. Wilkinson HA, et al. Genetics, 1995 Oct. PMID 8647389, Free PMC Article
  2. Genetic characterization of smg-8 mutants reveals no role in C. elegans nonsense mediated decay. Rosains J, et al. PLoS One, 2012. PMID 23166684, Free PMC Article
  3. A Role for the Nonsense-Mediated mRNA Decay Pathway in Maintaining Genome Stability in Caenorhabditis elegans. González-Huici V, et al. Genetics, 2017 Aug. PMID 28634159, Free PMC Article
  4. Carboxy-terminal truncation activates glp-1 protein to specify vulval fates in Caenorhabditis elegans. Mango SE, et al. Nature, 1991 Aug 29. PMID 1881436
  5. Global regulatory features of alternative splicing across tissues and within the nervous system of C. elegans. Koterniak B, et al. Genome Res, 2020 Dec. PMID 33127752, Free PMC Article

See all (74) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A novel role is reported for smg-1 in lifespan and oxidative stress resistance in Caenorhabditis elegans.
    Title: A novel role for the SMG-1 kinase in lifespan and oxidative stress resistance in Caenorhabditis elegans.
  2. smg-1 encodes a protein kinase of the phosphatidylinositol kinase superfamily of protein kinases; SMG-1 kinase activity is required in vivo for nonsense-mediated mRNA decay and in vitro for SMG-2 phosphorylation
    Title: SMG-1 is a phosphatidylinositol kinase-related protein kinase required for nonsense-mediated mRNA Decay in Caenorhabditis elegans.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in TOR signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in male genitalia development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of macroautophagy IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IEA
Inferred from Electronic Annotation
more info
  
involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of TOR complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Serine/threonine-protein kinase smg-1
NP_001021053.1
  • Confirmed by transcript evidence
NP_001361976.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    6900949..6913579 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001025882.5 → NP_001021053.1  Serine/threonine-protein kinase smg-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001021053.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O01510, Q6BEW0, Q9U9U7
    Conserved Domains (3) summary
    cd05170
    Location:1751 → 2058
    PIKKc_SMG1; Catalytic domain of Suppressor of Morphogenetic effect on Genitalia-1
    pfam02260
    Location:2291 → 2321
    FATC; FATC domain
    pfam15785
    Location:468 → 985
    SMG1; Serine/threonine-protein kinase smg-1

  2. NM_001374908.2 → NP_001361976.1  Serine/threonine-protein kinase smg-1 [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (3) summary
    cd05170
    Location:1753 → 2060
    PIKKc_SMG1; Catalytic domain of Suppressor of Morphogenetic effect on Genitalia-1
    pfam02260
    Location:2293 → 2323
    FATC; FATC domain
    pfam15785
    Location:468 → 984
    SMG1; Serine/threonine-protein kinase smg-1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O01510.3

Gene LinkOut

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