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lrp-1 Low-density lipoprotein receptor-related protein [ Caenorhabditis elegans ]

Gene ID: 172520, updated on 2-Nov-2024

Summary

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Official Symbol
lrp-1
Official Full Name
Low-density lipoprotein receptor-related protein
Primary source
WormBase:WBGene00003071
Locus tag
CELE_F29D11.1
See related
AllianceGenome:WB:WBGene00003071
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable calcium ion binding activity. Involved in several processes, including ecdysis, collagen and cuticulin-based cuticle; nematode larval development; and sterol transport. Located in apical plasma membrane and endocytic vesicle. Is expressed in head and hypodermis. Human ortholog(s) of this gene implicated in Donnai-Barrow syndrome and autoimmune thyroiditis. Orthologous to human LRP2 (LDL receptor related protein 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See lrp-1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
27
Sequence:
Chromosome: I; NC_003279.8 (7614176..7634143)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene C2 domain-containing protein aex-1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Condensin complex subunit capg-1 Neighboring gene ncRNA Neighboring gene Lipid droplet-associated hydrolase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A gp330/megalin-related protein is required in the major epidermis of Caenorhabditis elegans for completion of molting. Yochem J, et al. Development, 1999 Feb. PMID 9876188
  2. Low density lipoprotein receptors LRP-1 and LRP-2 in C. elegans. Minor P, et al. MicroPubl Biol, 2019 Aug 27. PMID 32550404, Free PMC Article
  3. Regulation of neuronal APL-1 expression by cholesterol starvation. Wiese M, et al. PLoS One, 2012. PMID 22363792, Free PMC Article
  4. C. elegans peb-1 mutants exhibit pleiotropic defects in molting, feeding, and morphology. Fernandez AP, et al. Dev Biol, 2004 Dec 15. PMID 15581870
  5. Membrane transport in Caenorhabditis elegans: an essential role for VPS34 at the nuclear membrane. Roggo L, et al. EMBO J, 2002 Apr 2. PMID 11927551, Free PMC Article

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. EPN-1/epsin as an essential factor in promoting internalization of the C. elegans LDLR superfamily member LRP-1.
    Title: Caenorhabditis elegans reveals a FxNPxY-independent low-density lipoprotein receptor internalization mechanism mediated by epsin1.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in ecdysis, collagen and cuticulin-based cuticle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in endocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in nematode larval development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of locomotion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell migration IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in sterol transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in clathrin-coated pit IEA
Inferred from Electronic Annotation
more info
  
located_in endocytic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Low-density lipoprotein receptor-related protein
NP_001379135.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    7614176..7634143
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001392587.1 → NP_001379135.1  Low-density lipoprotein receptor-related protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q04833
    Conserved Domains (10) summary
    smart00192
    Location:1057 → 1087
    LDLa; Low-density lipoprotein receptor domain class A
    smart00135
    Location:2613 → 2655
    LY; Low-density lipoprotein-receptor YWTD domain
    smart00179
    Location:4132 → 4163
    EGF_CA; Calcium-binding EGF-like domain
    cd00112
    Location:3140 → 3174
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd05819
    Location:4219 → 4257
    NHL; NHL repeat [structural motif]
    cl18310
    Location:4219 → 4431
    NHL; NHL repeat unit of beta-propeller proteins
    pfam00058
    Location:3445 → 3490
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B
    pfam14670
    Location:3586 → 3623
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    NF033759
    Location:1054 → 1451
    exchanger_TraA; outer membrane exchange protein TraA
    cl39070
    Location:1943 → 1986
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q04833.1

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