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Mmp16 matrix metallopeptidase 16 [ Mus musculus (house mouse) ]

Gene ID: 17389, updated on 2-Nov-2024

Summary

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Official Symbol
Mmp16provided by MGI
Official Full Name
matrix metallopeptidase 16provided by MGI
Primary source
MGI:MGI:1276107
See related
Ensembl:ENSMUSG00000028226 AllianceGenome:MGI:1276107
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mt3mmp; MT3-MMP; MT-MMP 3
Summary
This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. The encoded preproprotein undergoes proteolytic processing to generate a mature, zinc-dependent endopeptidase enzyme. Mice lacking the encoded protein exhibit retarded growth of the skeleton, especially in the cranium and long bones. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
Expression
Biased expression in CNS E18 (RPKM 3.8), limb E14.5 (RPKM 3.0) and 8 other tissues See more
Orthologs
human all
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Genomic context

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See Mmp16 in Genome Data Viewer
Location:
4 A3; 4 7.08 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (17853072..18117479)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (17853072..18117479)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_09674 Neighboring gene STARR-seq mESC enhancer starr_09675 Neighboring gene predicted gene, 42257 Neighboring gene predicted gene, 30092 Neighboring gene STARR-seq mESC enhancer starr_09676 Neighboring gene STARR-seq mESC enhancer starr_09677 Neighboring gene STARR-seq mESC enhancer starr_09678 Neighboring gene STARR-seq mESC enhancer starr_09679 Neighboring gene STARR-seq mESC enhancer starr_09680 Neighboring gene predicted gene 11860 Neighboring gene STARR-seq mESC enhancer starr_09681 Neighboring gene STARR-seq mESC enhancer starr_09682 Neighboring gene STARR-seq mESC enhancer starr_09683 Neighboring gene STARR-seq mESC enhancer starr_09685 Neighboring gene STARR-seq mESC enhancer starr_09686 Neighboring gene STARR-seq mESC enhancer starr_09687 Neighboring gene kinesin family member 2C pseudogene Neighboring gene STARR-seq mESC enhancer starr_09688 Neighboring gene STARR-seq mESC enhancer starr_09689 Neighboring gene cyclic nucleotide binding domain containing 1 Neighboring gene cytochrome b5 reductase 4 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Exploring the mechanism of artificial selection signature in Chinese indigenous pigs by leveraging multiple bioinformatics database tools. Feng X, et al. BMC Genomics, 2023 Dec 5. PMID 38053015, Free PMC Article
  2. Membrane-type matrix metalloproteinase-3 regulates neuronal responsiveness to myelin through Nogo-66 receptor 1 cleavage. Ferraro GB, et al. J Biol Chem, 2011 Sep 9. PMID 21768085, Free PMC Article
  3. Membrane-type MMPs enable extracellular matrix permissiveness and mesenchymal cell proliferation during embryogenesis. Shi J, et al. Dev Biol, 2008 Jan 1. PMID 18022611, Free PMC Article
  4. Mapping of two mouse membrane-type matrix metalloproteinase (MT-MMP) genes, Mmp15 and Mmp16, to mouse chromosomes 8 and 4, respectively. Seldin MF, et al. Genomics, 1998 Jun 1. PMID 9653660
  5. Matrix metalloproteinases mediate the dismantling of mesenchymal structures in the tadpole tail during thyroid hormone-induced tail resorption. Jung JC, et al. Dev Dyn, 2002 Mar. PMID 11891989

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. miR-155 contributed to the up-regulation of MMP-16, and MMP-16 further degraded aggrecan and collagen type II, leading to the dehydration and degeneration of intervertebral discs
    Title: Role of miR-155 in the regulation of MMP-16 expression in intervertebral disc degeneration.
  2. Neuronal knockdown of MT3-MMP resulted in the accumulation of NgR1 at the cell surface and reduced the accumulation of the NgR1 cleavage fragment in medium conditioned by cortical neurons
    Title: Membrane-type matrix metalloproteinase-3 regulates neuronal responsiveness to myelin through Nogo-66 receptor 1 cleavage.
  3. Study demonstrates that MT3-MMP, is expressed in mesenchymal tissues of the skeleton and in peri-skeletal soft connective tissue; and MT3-MMP-deficient mice display growth inhibition tied to a decreased viability of mesenchymal cells in skeletal tissues.
    Title: Membrane-type MMPs enable extracellular matrix permissiveness and mesenchymal cell proliferation during embryogenesis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (4)  1 citation

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metalloaminopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables metalloaminopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables metalloendopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within bone development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within chondrocyte proliferation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in collagen catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within collagen catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within collagen catabolic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within craniofacial suture morphogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within embryonic cranial skeleton morphogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within endochondral ossification IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in extracellular matrix organization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within ossification IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in protein processing IEA
Inferred from Electronic Annotation
more info
  
involved_in protein processing ISO
Inferred from Sequence Orthology
more info
  
involved_in proteolysis ISO
Inferred from Sequence Orthology
more info
  
involved_in skeletal system development IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in extracellular matrix IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
matrix metalloproteinase-16
Names
Membrane type 3-MMP
membrane-type matrix metalloproteinase 3
NP_001366447.1
NP_001366448.1
NP_062698.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001379518.1 → NP_001366447.1  matrix metalloproteinase-16 preproprotein

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3), as well as variants 1 and 4, encodes the functional protein.
    Source sequence(s)
    AL683877, AL805957
    UniProtKB/Swiss-Prot
    Q6PEQ6, Q9ERT6, Q9WTR0
    Conserved Domains (5) summary
    PHA03247
    Location:292 → 338
    PHA03247; large tegument protein UL36; Provisional
    cd00094
    Location:340 → 532
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    pfam00413
    Location:126 → 291
    Peptidase_M10; Matrixin
    pfam01471
    Location:46 → 96
    PG_binding_1; Putative peptidoglycan binding domain
    pfam11857
    Location:537 → 607
    DUF3377; Domain of unknown function (DUF3377)

  2. NM_001379519.1 → NP_001366448.1  matrix metalloproteinase-16 preproprotein

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4), as well as variants 1 and 3, encodes the functional protein.
    Source sequence(s)
    AL683877, AL805957
    UniProtKB/Swiss-Prot
    Q6PEQ6, Q9ERT6, Q9WTR0
    Conserved Domains (5) summary
    PHA03247
    Location:292 → 338
    PHA03247; large tegument protein UL36; Provisional
    cd00094
    Location:340 → 532
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    pfam00413
    Location:126 → 291
    Peptidase_M10; Matrixin
    pfam01471
    Location:46 → 96
    PG_binding_1; Putative peptidoglycan binding domain
    pfam11857
    Location:537 → 607
    DUF3377; Domain of unknown function (DUF3377)

  3. NM_019724.5 → NP_062698.2  matrix metalloproteinase-16 preproprotein

    See identical proteins and their annotated locations for NP_062698.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the functional protein. Variants 1, 3, and 4 all encode the same protein.
    Source sequence(s)
    AL683877, AL805957
    Consensus CDS
    CCDS17989.1
    UniProtKB/Swiss-Prot
    Q6PEQ6, Q9ERT6, Q9WTR0
    Related
    ENSMUSP00000029881.4, ENSMUST00000029881.10
    Conserved Domains (5) summary
    PHA03247
    Location:292 → 338
    PHA03247; large tegument protein UL36; Provisional
    cd00094
    Location:340 → 532
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    pfam00413
    Location:126 → 291
    Peptidase_M10; Matrixin
    pfam01471
    Location:46 → 96
    PG_binding_1; Putative peptidoglycan binding domain
    pfam11857
    Location:537 → 607
    DUF3377; Domain of unknown function (DUF3377)

RNA

  1. NR_135158.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains two alternate exons and uses an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL683877, AL805957
    Related
    ENSMUST00000183662.8

  2. NR_166735.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL683877, AL805957

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    17853072..18117479
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9WTR0.3 GenPept UniProtKB/Swiss-Prot:Q9WTR0

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