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set-17 Histone-lysine N-methyltransferase set-17 [ Caenorhabditis elegans ]

Gene ID: 174425, updated on 2-Nov-2024

Summary

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Official Symbol
set-17
Official Full Name
Histone-lysine N-methyltransferase set-17
Primary source
WormBase:WBGene00011887
Locus tag
CELE_T21B10.5
See related
AllianceGenome:WB:WBGene00011887
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables histone H3K4 methyltransferase activity. Predicted to be involved in chromatin remodeling and methylation. Predicted to be located in nucleus. Is expressed in several structures, including excretory cell; germ line; intestine; primary spermatocyte; and vulval muscle. Orthologous to human PRDM7 (PR/SET domain 7). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See set-17 in Genome Data Viewer
Location:
chromosome: II
Exon count:
7
Sequence:
Chromosome: II; NC_003280.10 (8939054..8940488, complement)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Enolase Neighboring gene THO complex subunit 2 Neighboring gene Uncharacterized protein Neighboring gene ZP domain-containing protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A Caenorhabditis elegans protein with a PRDM9-like SET domain localizes to chromatin-associated foci and promotes spermatocyte gene expression, sperm production and fertility. Engert CG, et al. PLoS Genet, 2018 Apr. PMID 29702639, Free PMC Article
  2. Photoaged Polystyrene Nanoplastics Result in Transgenerational Reproductive Toxicity Associated with the Methylation of Histone H3K4 and H3K9 in Caenorhabditis elegans. Chen H, et al. Environ Sci Technol, 2023 Dec 5. PMID 37934861
  3. Mutation of C. elegans demethylase spr-5 extends transgenerational longevity. Greer EL, et al. Cell Res, 2016 Feb. PMID 26691751, Free PMC Article
  4. The GATA transcription factor ELT-2 modulates both the expression and methyltransferase activity of PRMT-1 in Caenorhabditis elegans. Araoi S, et al. J Biochem, 2018 May 1. PMID 29361115
  5. A histone methylation network regulates transgenerational epigenetic memory in C. elegans. Greer EL, et al. Cell Rep, 2014 Apr 10. PMID 24685137, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. the germline-expressed C. elegans protein SET-17, which has a SET domain similar to that of the PRDM9 and PRDM7 SET-domain proteins, promotes fertility by regulating gene expression in primary spermatocytes
    Title: A Caenorhabditis elegans protein with a PRDM9-like SET domain localizes to chromatin-associated foci and promotes spermatocyte gene expression, sperm production and fertility.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables histone H3K4 methyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone H3K4 monomethyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in methylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Histone-lysine N-methyltransferase set-17
NP_001317778.1
  • Partially confirmed by transcript evidence
NP_001368599.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    8939054..8940488 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001330955.2 → NP_001317778.1  Histone-lysine N-methyltransferase set-17 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A0A163UT06, A0A168H266
    Conserved Domains (2) summary
    cd19193
    Location:128 → 255
    PR-SET_PRDM7_9; PR-SET domain found in PR domain zinc finger protein 7 (PRDM7) and 9 (PRDM9) and similar proteins
    cl22851
    Location:82 → 113
    PHD_SF; PHD finger superfamily

  2. NM_001381544.1 → NP_001368599.1  Histone-lysine N-methyltransferase set-17 [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (2) summary
    cd19193
    Location:116 → 243
    PR-SET_PRDM7_9; PR-SET domain found in PR domain zinc finger protein 7 (PRDM7) and 9 (PRDM9) and similar proteins
    cl22851
    Location:70 → 101
    PHD_SF; PHD finger superfamily
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A163UT06.1

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