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szy-20 SUZ domain-containing protein;Suppressor of zyg-1 protein 20 [ Caenorhabditis elegans ]

Gene ID: 174430, updated on 2-Nov-2024

Summary

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Official Symbol
szy-20
Official Full Name
SUZ domain-containing protein;Suppressor of zyg-1 protein 20
Primary source
WormBase:WBGene00004105
Locus tag
CELE_C18E9.3
See related
AllianceGenome:WB:WBGene00004105
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable RNA binding activity. Involved in several processes, including negative regulation of protein localization to centrosome; positive regulation of fertilization; and regulation of cell cycle process. Located in centrosome; cytoplasm; and nucleolus. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See szy-20 in Genome Data Viewer
Location:
chromosome: II
Exon count:
7
Sequence:
Chromosome: II; NC_003280.10 (8966921..8969333, complement)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 Neighboring gene Translocation protein SEC62 Neighboring gene uncharacterized protein Neighboring gene Mitochondrial import receptor subunit TOM40 homolog Neighboring gene Fibronectin type-III domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The conserved protein SZY-20 opposes the Plk4-related kinase ZYG-1 to limit centrosome size. Song MH, et al. Dev Cell, 2008 Dec. PMID 19081077, Free PMC Article
  2. Correction: ATX-2, The C. elegans Ortholog of Human Ataxin-2, Regulates Centrosome Size and Microtubule Dynamics. Stubenvoll MD, et al. PLoS Genet, 2016 Dec. PMID 28027322, Free PMC Article
  3. Casein kinase II is required for proper cell division and acts as a negative regulator of centrosome duplication in Caenorhabditis elegans embryos. Medley JC, et al. Biol Open, 2017 Jan 15. PMID 27881437, Free PMC Article
  4. ATX-2, the C. elegans Ortholog of Human Ataxin-2, Regulates Centrosome Size and Microtubule Dynamics. Stubenvoll MD, et al. PLoS Genet, 2016 Sep. PMID 27689799, Free PMC Article
  5. Protein phosphatase 2A-SUR-6/B55 regulates centriole duplication in C. elegans by controlling the levels of centriole assembly factors. Song MH, et al. Dev Cell, 2011 Apr 19. PMID 21497766, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in cell division IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in embryo development ending in birth or egg hatching IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in meiotic chromosome segregation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of protein localization to centrosome IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of protein localization to centrosome IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of fertilization IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of mitotic cell cycle, embryonic IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of mitotic cytokinetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of centrosome duplication IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of mitotic cell cycle, embryonic IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of mitotic cytokinetic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of spindle assembly IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in centriole IEA
Inferred from Electronic Annotation
more info
  
located_in centrosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in centrosome IEA
Inferred from Electronic Annotation
more info
  
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
SUZ domain-containing protein;Suppressor of zyg-1 protein 20
NP_001021977.2
  • Confirmed by transcript evidence
NP_001122590.1
  • Confirmed by transcript evidence
NP_001129808.1
  • Confirmed by transcript evidence
NP_001254187.1
  • Confirmed by transcript evidence
NP_001254188.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    8966921..8969333 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001136336.3 → NP_001129808.1  Suppressor of zyg-1 protein 20 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001129808.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G5EGU9
    Conserved Domains (1) summary
    pfam12752
    Location:69 → 145
    SUZ; SUZ domain

  2. NM_001026806.7 → NP_001021977.2  SUZ domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001021977.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q565A8
    Conserved Domains (1) summary
    pfam12752
    Location:69 → 146
    SUZ; SUZ domain

  3. NM_001129118.4 → NP_001122590.1  SUZ domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001122590.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B2D6L4
    Conserved Domains (1) summary
    pfam12752
    Location:72 → 149
    SUZ; SUZ domain

  4. NM_001267258.3 → NP_001254187.1  Suppressor of zyg-1 protein 20 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001254187.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A9P338, A9P339, G5EEB4, G5EGU9
    Conserved Domains (1) summary
    pfam12752
    Location:69 → 146
    SUZ; SUZ domain

  5. NM_001267259.3 → NP_001254188.1  SUZ domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001254188.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    D2KT99
    Conserved Domains (1) summary
    pfam12752
    Location:72 → 149
    SUZ; SUZ domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
G5EGU9.1

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