unc-52 Basement membrane proteoglycan;Basement membrane-specific heparan sulfate proteoglycan core protein;Ig-like domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: unc-52
Official Full Name: Basement membrane proteoglycan;Basement membrane-specific heparan sulfate proteoglycan core protein;Ig-like domain-containing protein
Primary source: WormBase:WBGene00006787
Locus tag: CELE_ZC101.2
See related: AllianceGenome:WB:WBGene00006787
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: An extracellular matrix structural constituent. Involved in several processes, including hemidesmosome assembly; muscle cell cellular homeostasis; and nematode pharyngeal gland morphogenesis. Located in basement membrane and striated muscle dense body. Is expressed in several structures, including intestine; non-striated muscle; pharyngeal-intestinal valve; pharynx; and reproductive system. Human ortholog(s) of this gene implicated in Schwartz-Jampel syndrome 1; Silverman-Handmaker type dyssegmental dysplasia; and osteochondrodysplasia. Orthologous to human HSPG2 (heparan sulfate proteoglycan 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See unc-52 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 48

Sequence:: Chromosome: II; NC_003280.10 (14647321..14684456, complement)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The RGD (Arg-Gly-Asp) is a potential cell-binding motif of UNC-52/PERLECAN.
Title: The RGD (Arg-Gly-Asp) is a potential cell-binding motif of UNC-52/PERLECAN.
CCAR-1 physically interacts with HRP-2, a splicing factor known to mediate unc-52 alternative splicing to control the proportions of different UNC-52 isoforms and stabilize hemidesmosomes .
Title: CCAR-1 affects hemidesmosome biogenesis by regulating unc-52/perlecan alternative splicing in the C. elegans epidermis.
the conserved basement membrane protein UNC-52/Perlecan is required for establishing the correct number of the highly ordered dendritic trees in the somatosensory neuron PVD in Caenorhabditis elegans.
Title: Four specific immunoglobulin domains in UNC-52/Perlecan function with NID-1/Nidogen during dendrite morphogenesis in Caenorhabditis elegans.
A perlecan/UNC-52 splice variant is necessary for Fibulin-1D assembly at uterine and mechanosensory neurons attachments.
Title: Selective assembly of fibulin-1 splice variants reveals distinct extracellular matrix networks and novel functions for perlecan/UNC-52 splice variants.
UNC-52 serves dual roles in larval development in the maintenance of muscle structure and the regulation of growth factor-like signaling pathways.
Title: UNC-52/perlecan affects gonadal leader cell migrations in C. elegans hermaphrodites through alterations in growth factor signaling.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

ZC101.2 (e-PCR)
- UniSTS:317550

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables extracellular matrix structural constituent	IBA Inferred from Biological aspect of Ancestor more info
enables extracellular matrix structural constituent	IMP Inferred from Mutant Phenotype more info	PubMed
enables structural molecule activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in animal organ morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in axon guidance	IEA Inferred from Electronic Annotation more info
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in cell migration	IGI Inferred from Genetic Interaction more info	PubMed
involved_in embryo development ending in birth or egg hatching	IGI Inferred from Genetic Interaction more info	PubMed
involved_in fibroblast growth factor receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in hemidesmosome assembly	IGI Inferred from Genetic Interaction more info	PubMed
involved_in locomotion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitochondrion organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in muscle cell cellular homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in muscle organ development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in muscle organ morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in myofibril assembly	IEP Inferred from Expression Pattern more info	PubMed
involved_in nematode larval development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nematode pharyngeal gland morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nematode pharynx development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of locomotion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of ovulation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of sarcomere organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tissue development	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in M band	IEA Inferred from Electronic Annotation more info
is_active_in basement membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in basement membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basement membrane	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in extracellular matrix	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in striated muscle dense body	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Basement membrane proteoglycan;Basement membrane-specific heparan sulfate proteoglycan core protein;Ig-like domain-containing protein

NP_001022488.1

Confirmed by transcript evidence

NP_001254438.1

Confirmed by transcript evidence

NP_001254439.1

Confirmed by transcript evidence

NP_001254440.1

Confirmed by transcript evidence

NP_001254442.1

Confirmed by transcript evidence

NP_001254443.1

Confirmed by transcript evidence

NP_001254444.1

Confirmed by transcript evidence

NP_001254445.1

Confirmed by transcript evidence

NP_001254446.1

Partially confirmed by transcript evidence

NP_001293585.1

Confirmed by transcript evidence

NP_001337294.1

Confirmed by transcript evidence

NP_001364664.1

Confirmed by transcript evidence

NP_497044.3

Confirmed by transcript evidence

NP_497045.1

Confirmed by transcript evidence

NP_497046.1

Confirmed by transcript evidence

NP_497047.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

14647321..14684456 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001377905.2 → NP_001364664.1 Basement membrane-specific heparan sulfate proteoglycan core protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

G5EEI5

Conserved Domains (16) summary

cd05743
Location:1075 → 1152

Ig_Perlecan_like; Immunoglobulin (Ig)-like domain of the human basement membrane heparan sulfate proteoglycan perlecan and similar proteins

smart00180
Location:1172 → 1218

EGF_Lam; Laminin-type epidermal growth factor-like domai

smart00281
Location:1578 → 1702

LamB; Laminin B domain

smart00282
Location:3513 → 3644

LamG; Laminin G domain

smart00409
Location:1932 → 2012

IG; Immunoglobulin

smart00410
Location:2404 → 2486

IG_like; Immunoglobulin like

cd00054
Location:3411 → 3448

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:3882 → 4040

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

cd00112
Location:416 → 450

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

pfam00053
Location:1748 → 1795

Laminin_EGF; Laminin EGF domain

pfam00057
Location:1020 → 1057

Ldl_recept_a; Low-density lipoprotein receptor domain class A

pfam13927
Location:2673 → 2756

Ig_3; Immunoglobulin domain

cd00096
Location:3070 → 3077

Ig; Ig strand B [structural motif]

cd05754
Location:834 → 919

IgI_Perlecan_like; Immunoglobulin (Ig)-like domain found in Perlecan and similar proteins; member of the I-set of Ig superfamily (IgSF) domains

cl00104
Location:977 → 1013

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

cl11960
Location:3067 → 3137

Ig; Immunoglobulin domain
NM_064643.10 → NP_497044.3 Basement membrane proteoglycan [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_497044.3

Status: REVIEWED

UniProtKB/Swiss-Prot

O18261, O18263, Q06561, Q6BEQ6, Q9U7E8, Q9XTD2, Q9XTI5

Conserved Domains (16) summary

cd05743
Location:286 → 363

Ig_Perlecan_D2_like; Immunoglobulin (Ig)-like domain II (D2) of the human basement membrane heparan sulfate proteoglycan perlecan, also known as HSPG2

smart00408
Location:2366 → 2427

IGc2; Immunoglobulin C-2 Type

smart00180
Location:383 → 429

EGF_Lam; Laminin-type epidermal growth factor-like domai

smart00281
Location:785 → 909

LamB; Laminin B domain

smart00282
Location:2813 → 2944

LamG; Laminin G domain

smart00409
Location:1512 → 1593

IG; Immunoglobulin

smart00410
Location:1232 → 1312

IG_like; Immunoglobulin like

cd00054
Location:2711 → 2748

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:3182 → 3340

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam07679
Location:271 → 356

I-set; Immunoglobulin I-set domain

pfam00047
Location:1418 → 1493

ig; Immunoglobulin domain

pfam00053
Location:955 → 1002

Laminin_EGF; Laminin EGF domain

pfam00057
Location:231 → 268

Ldl_recept_a; Low-density lipoprotein receptor domain class A

pfam13895
Location:1599 → 1683

Ig_2; Immunoglobulin domain

cl00104
Location:188 → 224

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

cl11960
Location:45 → 130

Ig; Immunoglobulin domain
NM_001267509.3 → NP_001254438.1 Basement membrane-specific heparan sulfate proteoglycan core protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001254438.1

Status: REVIEWED

UniProtKB/TrEMBL

G1K109

Conserved Domains (4) summary

smart00282
Location:314 → 445

LamG; Laminin G domain

cd00054
Location:212 → 249

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:683 → 841

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00008
Location:255 → 284

EGF; EGF-like domain
NM_064645.6 → NP_497046.1 Basement membrane proteoglycan [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_497046.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q06561

Conserved Domains (13) summary

cd05743
Location:286 → 363

Ig_Perlecan_D2_like; Immunoglobulin (Ig)-like domain II (D2) of the human basement membrane heparan sulfate proteoglycan perlecan, also known as HSPG2

smart00408
Location:2366 → 2427

IGc2; Immunoglobulin C-2 Type

smart00180
Location:383 → 429

EGF_Lam; Laminin-type epidermal growth factor-like domai

smart00281
Location:785 → 909

LamB; Laminin B domain

smart00409
Location:1512 → 1593

IG; Immunoglobulin

smart00410
Location:1232 → 1312

IG_like; Immunoglobulin like

pfam07679
Location:271 → 356

I-set; Immunoglobulin I-set domain

pfam00047
Location:1418 → 1493

ig; Immunoglobulin domain

pfam00053
Location:955 → 1002

Laminin_EGF; Laminin EGF domain

pfam00057
Location:231 → 268

Ldl_recept_a; Low-density lipoprotein receptor domain class A

pfam13895
Location:1599 → 1683

Ig_2; Immunoglobulin domain

cl00104
Location:188 → 224

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

cl11960
Location:45 → 130

Ig; Immunoglobulin domain
NM_001027317.8 → NP_001022488.1 Basement membrane proteoglycan [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001022488.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q06561

Conserved Domains (13) summary

cd05743
Location:286 → 363

Ig_Perlecan_D2_like; Immunoglobulin (Ig)-like domain II (D2) of the human basement membrane heparan sulfate proteoglycan perlecan, also known as HSPG2

smart00408
Location:2273 → 2334

IGc2; Immunoglobulin C-2 Type

smart00180
Location:383 → 429

EGF_Lam; Laminin-type epidermal growth factor-like domai

smart00281
Location:785 → 909

LamB; Laminin B domain

smart00409
Location:1327 → 1407

IG; Immunoglobulin

smart00410
Location:1139 → 1219

IG_like; Immunoglobulin like

pfam07679
Location:271 → 356

I-set; Immunoglobulin I-set domain

pfam00047
Location:1325 → 1400

ig; Immunoglobulin domain

pfam00053
Location:955 → 1002

Laminin_EGF; Laminin EGF domain

pfam00057
Location:231 → 268

Ldl_recept_a; Low-density lipoprotein receptor domain class A

pfam13895
Location:1506 → 1590

Ig_2; Immunoglobulin domain

cl00104
Location:188 → 224

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

cl11960
Location:45 → 130

Ig; Immunoglobulin domain
NM_064644.6 → NP_497045.1 Basement membrane proteoglycan [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_497045.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q06561

Conserved Domains (13) summary

cd05743
Location:286 → 363

Ig_Perlecan_D2_like; Immunoglobulin (Ig)-like domain II (D2) of the human basement membrane heparan sulfate proteoglycan perlecan, also known as HSPG2

smart00408
Location:2179 → 2240

IGc2; Immunoglobulin C-2 Type

smart00180
Location:383 → 429

EGF_Lam; Laminin-type epidermal growth factor-like domai

smart00281
Location:785 → 909

LamB; Laminin B domain

smart00409
Location:1512 → 1593

IG; Immunoglobulin

smart00410
Location:1232 → 1312

IG_like; Immunoglobulin like

pfam07679
Location:271 → 356

I-set; Immunoglobulin I-set domain

pfam00047
Location:1418 → 1493

ig; Immunoglobulin domain

pfam00053
Location:955 → 1002

Laminin_EGF; Laminin EGF domain

pfam00057
Location:231 → 268

Ldl_recept_a; Low-density lipoprotein receptor domain class A

pfam13895
Location:1599 → 1683

Ig_2; Immunoglobulin domain

cl00104
Location:188 → 224

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

cl11960
Location:45 → 130

Ig; Immunoglobulin domain
NM_001267515.3 → NP_001254444.1 Basement membrane proteoglycan [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001254444.1

Status: REVIEWED

UniProtKB/TrEMBL

H9G348

Conserved Domains (13) summary

cd05743
Location:286 → 363

Ig_Perlecan_D2_like; Immunoglobulin (Ig)-like domain II (D2) of the human basement membrane heparan sulfate proteoglycan perlecan, also known as HSPG2

smart00408
Location:2267 → 2328

IGc2; Immunoglobulin C-2 Type

smart00180
Location:383 → 429

EGF_Lam; Laminin-type epidermal growth factor-like domai

smart00281
Location:785 → 909

LamB; Laminin B domain

smart00409
Location:1512 → 1593

IG; Immunoglobulin

smart00410
Location:1232 → 1312

IG_like; Immunoglobulin like

pfam07679
Location:271 → 356

I-set; Immunoglobulin I-set domain

pfam00047
Location:1418 → 1493

ig; Immunoglobulin domain

pfam00053
Location:955 → 1002

Laminin_EGF; Laminin EGF domain

pfam00057
Location:231 → 268

Ldl_recept_a; Low-density lipoprotein receptor domain class A

pfam13895
Location:1228 → 1312

Ig_2; Immunoglobulin domain

cl00104
Location:188 → 224

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

cl11960
Location:45 → 130

Ig; Immunoglobulin domain
NM_001267516.3 → NP_001254445.1 Basement membrane proteoglycan [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001254445.1

Status: REVIEWED

UniProtKB/TrEMBL

H9G349

Conserved Domains (13) summary

cd05743
Location:286 → 363

Ig_Perlecan_D2_like; Immunoglobulin (Ig)-like domain II (D2) of the human basement membrane heparan sulfate proteoglycan perlecan, also known as HSPG2

smart00408
Location:2272 → 2333

IGc2; Immunoglobulin C-2 Type

smart00180
Location:383 → 429

EGF_Lam; Laminin-type epidermal growth factor-like domai

smart00281
Location:785 → 909

LamB; Laminin B domain

smart00409
Location:1512 → 1593

IG; Immunoglobulin

smart00410
Location:1232 → 1312

IG_like; Immunoglobulin like

pfam07679
Location:271 → 356

I-set; Immunoglobulin I-set domain

pfam00047
Location:1418 → 1493

ig; Immunoglobulin domain

pfam00053
Location:955 → 1002

Laminin_EGF; Laminin EGF domain

pfam00057
Location:231 → 268

Ldl_recept_a; Low-density lipoprotein receptor domain class A

pfam13895
Location:1599 → 1683

Ig_2; Immunoglobulin domain

cl00104
Location:188 → 224

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

cl11960
Location:45 → 130

Ig; Immunoglobulin domain
NM_001267517.3 → NP_001254446.1 Basement membrane proteoglycan [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001254446.1

Status: REVIEWED

UniProtKB/TrEMBL

H9G350

Conserved Domains (13) summary

cd05743
Location:286 → 363

Ig_Perlecan_D2_like; Immunoglobulin (Ig)-like domain II (D2) of the human basement membrane heparan sulfate proteoglycan perlecan, also known as HSPG2

smart00408
Location:2363 → 2424

IGc2; Immunoglobulin C-2 Type

smart00180
Location:383 → 429

EGF_Lam; Laminin-type epidermal growth factor-like domai

smart00281
Location:785 → 909

LamB; Laminin B domain

smart00409
Location:1420 → 1500

IG; Immunoglobulin

smart00410
Location:1232 → 1312

IG_like; Immunoglobulin like

pfam07679
Location:271 → 356

I-set; Immunoglobulin I-set domain

pfam00047
Location:1418 → 1493

ig; Immunoglobulin domain

pfam00053
Location:955 → 1002

Laminin_EGF; Laminin EGF domain

pfam00057
Location:231 → 268

Ldl_recept_a; Low-density lipoprotein receptor domain class A

pfam13895
Location:1599 → 1683

Ig_2; Immunoglobulin domain

cl00104
Location:188 → 224

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

cl11960
Location:45 → 130

Ig; Immunoglobulin domain
NM_001267513.3 → NP_001254442.1 Basement membrane proteoglycan [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001254442.1

Status: REVIEWED

UniProtKB/TrEMBL

H9G353

Conserved Domains (13) summary

cd05743
Location:286 → 363

Ig_Perlecan_D2_like; Immunoglobulin (Ig)-like domain II (D2) of the human basement membrane heparan sulfate proteoglycan perlecan, also known as HSPG2

smart00408
Location:2080 → 2141

IGc2; Immunoglobulin C-2 Type

smart00180
Location:383 → 429

EGF_Lam; Laminin-type epidermal growth factor-like domai

smart00281
Location:785 → 909

LamB; Laminin B domain

smart00409
Location:1512 → 1593

IG; Immunoglobulin

smart00410
Location:1232 → 1312

IG_like; Immunoglobulin like

pfam07679
Location:271 → 356

I-set; Immunoglobulin I-set domain

pfam00047
Location:1418 → 1493

ig; Immunoglobulin domain

pfam00053
Location:955 → 1002

Laminin_EGF; Laminin EGF domain

pfam00057
Location:231 → 268

Ldl_recept_a; Low-density lipoprotein receptor domain class A

pfam13895
Location:1228 → 1312

Ig_2; Immunoglobulin domain

cl00104
Location:188 → 224

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

cl11960
Location:45 → 130

Ig; Immunoglobulin domain
NM_001267514.4 → NP_001254443.1 Basement membrane proteoglycan [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001254443.1

Status: REVIEWED

UniProtKB/TrEMBL

H9G354

Conserved Domains (13) summary

cd05743
Location:286 → 363

Ig_Perlecan_D2_like; Immunoglobulin (Ig)-like domain II (D2) of the human basement membrane heparan sulfate proteoglycan perlecan, also known as HSPG2

smart00408
Location:2173 → 2234

IGc2; Immunoglobulin C-2 Type

smart00180
Location:383 → 429

EGF_Lam; Laminin-type epidermal growth factor-like domai

smart00281
Location:785 → 909

LamB; Laminin B domain

smart00409
Location:1512 → 1593

IG; Immunoglobulin

smart00410
Location:1232 → 1312

IG_like; Immunoglobulin like

pfam07679
Location:271 → 356

I-set; Immunoglobulin I-set domain

pfam00047
Location:1418 → 1493

ig; Immunoglobulin domain

pfam00053
Location:955 → 1002

Laminin_EGF; Laminin EGF domain

pfam00057
Location:231 → 268

Ldl_recept_a; Low-density lipoprotein receptor domain class A

pfam13895
Location:1228 → 1312

Ig_2; Immunoglobulin domain

cl00104
Location:188 → 224

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

cl11960
Location:45 → 130

Ig; Immunoglobulin domain
NM_001350388.3 → NP_001337294.1 Basement membrane-specific heparan sulfate proteoglycan core protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1T5HUZ1

Conserved Domains (14) summary

cd05743
Location:1075 → 1152

Ig_Perlecan_like; Immunoglobulin (Ig)-like domain of the human basement membrane heparan sulfate proteoglycan perlecan, also known as HSPG2, and similar domains

cd05754
Location:834 → 919

Ig_Perlecan_like; Igmmunoglobulin (Ig)-like domain found in Perlecan and similar proteins

smart00408
Location:3155 → 3216

IGc2; Immunoglobulin C-2 Type

smart00180
Location:1172 → 1218

EGF_Lam; Laminin-type epidermal growth factor-like domai

smart00281
Location:1574 → 1698

LamB; Laminin B domain

smart00409
Location:2021 → 2101

IG; Immunoglobulin

smart00410
Location:2301 → 2382

IG_like; Immunoglobulin like

cd00112
Location:416 → 450

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

pfam00053
Location:1744 → 1791

Laminin_EGF; Laminin EGF domain

pfam00057
Location:1020 → 1057

Ldl_recept_a; Low-density lipoprotein receptor domain class A

cl00104
Location:977 → 1013

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

pfam13895
Location:2387 → 2472

Ig_2; Immunoglobulin domain

pfam13927
Location:2674 → 2747

Ig_3; Immunoglobulin domain

cl11960
Location:1919 → 2007

Ig; Immunoglobulin domain
NM_001267510.3 → NP_001254439.1 Basement membrane proteoglycan [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001254439.1

Status: REVIEWED

UniProtKB/TrEMBL

H9G352

Conserved Domains (13) summary

cd05743
Location:286 → 363

Ig_Perlecan_D2_like; Immunoglobulin (Ig)-like domain II (D2) of the human basement membrane heparan sulfate proteoglycan perlecan, also known as HSPG2

smart00408
Location:2077 → 2138

IGc2; Immunoglobulin C-2 Type

smart00180
Location:383 → 429

EGF_Lam; Laminin-type epidermal growth factor-like domai

smart00281
Location:496 → 620

LamB; Laminin B domain

smart00409
Location:1223 → 1304

IG; Immunoglobulin

smart00410
Location:943 → 1023

IG_like; Immunoglobulin like

pfam07679
Location:271 → 356

I-set; Immunoglobulin I-set domain

pfam00047
Location:1129 → 1204

ig; Immunoglobulin domain

pfam00053
Location:666 → 713

Laminin_EGF; Laminin EGF domain

pfam00057
Location:231 → 268

Ldl_recept_a; Low-density lipoprotein receptor domain class A

pfam13895
Location:1310 → 1394

Ig_2; Immunoglobulin domain

cl00104
Location:188 → 224

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

cl11960
Location:45 → 130

Ig; Immunoglobulin domain
NM_001267511.3 → NP_001254440.1 Basement membrane proteoglycan [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001254440.1

Status: REVIEWED

UniProtKB/TrEMBL

H9G351

Conserved Domains (13) summary

cd05743
Location:286 → 363

Ig_Perlecan_D2_like; Immunoglobulin (Ig)-like domain II (D2) of the human basement membrane heparan sulfate proteoglycan perlecan, also known as HSPG2

smart00408
Location:2180 → 2241

IGc2; Immunoglobulin C-2 Type

smart00180
Location:383 → 429

EGF_Lam; Laminin-type epidermal growth factor-like domai

smart00281
Location:785 → 909

LamB; Laminin B domain

smart00409
Location:1326 → 1407

IG; Immunoglobulin

smart00410
Location:1234 → 1314

IG_like; Immunoglobulin like

pfam07679
Location:271 → 356

I-set; Immunoglobulin I-set domain

pfam00047
Location:1232 → 1307

ig; Immunoglobulin domain

pfam00053
Location:955 → 1002

Laminin_EGF; Laminin EGF domain

pfam00057
Location:231 → 268

Ldl_recept_a; Low-density lipoprotein receptor domain class A

pfam13895
Location:1413 → 1497

Ig_2; Immunoglobulin domain

cl00104
Location:188 → 224

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

cl11960
Location:45 → 130

Ig; Immunoglobulin domain
NM_001306656.3 → NP_001293585.1 Ig-like domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001293585.1

Status: REVIEWED

UniProtKB/TrEMBL

U4PS79

Conserved Domains (1) summary

smart00408
Location:21 → 82

IGc2; Immunoglobulin C-2 Type
NM_064646.7 → NP_497047.1 Basement membrane proteoglycan [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_497047.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q06561

Conserved Domains (8) summary

cd05743
Location:286 → 363

Ig_Perlecan_D2_like; Immunoglobulin (Ig)-like domain II (D2) of the human basement membrane heparan sulfate proteoglycan perlecan, also known as HSPG2

smart00180
Location:383 → 429

EGF_Lam; Laminin-type epidermal growth factor-like domai

smart00281
Location:785 → 909

LamB; Laminin B domain

pfam07679
Location:271 → 356

I-set; Immunoglobulin I-set domain

pfam00053
Location:955 → 1002

Laminin_EGF; Laminin EGF domain

pfam00057
Location:231 → 268

Ldl_recept_a; Low-density lipoprotein receptor domain class A

cl00104
Location:188 → 224

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

cl11960
Location:45 → 130

Ig; Immunoglobulin domain