mrg-1 Mortality factor related protein 1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: mrg-1
Official Full Name: Mortality factor related protein 1
Primary source: WormBase:WBGene00003406
Locus tag: CELE_Y37D8A.9
See related: AllianceGenome:WB:WBGene00003406
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Involved in several processes, including chromosome attachment to the nuclear envelope; protein localization to euchromatin; and regulation of gene expression. Located in autosome and euchromatin. Is expressed in several structures, including AB; C; germ cell; germ line; and somatic cell. Orthologous to several human genes including MORF4L2 (mortality factor 4 like 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See mrg-1 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 4

Sequence:: Chromosome: III; NC_003281.10 (12871029..12874656, complement)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MRG-1 has two distinct functions: chromatin-based transcriptional silencing and preserving genomic integrity at the maintenance stage of primordial germ cells.
Title: MRG-1 is required for both chromatin-based transcriptional silencing and genomic integrity of primordial germ cells in Caenorhabditis elegans.
MRG-1 safeguards germ cells against conversion into neurons.
Title: MRG-1/MRG15 Is a Barrier for Germ Cell to Neuron Reprogramming in Caenorhabditis elegans.
Authors show that this characteristic spatiotemporal expression pattern is dictated by the mrg-1 3'UTR and is differentially regulated at the RNA level between germline and somatic cells
Title: Restricted distribution of mrg-1 mRNA in C. elegans primordial germ cells through germ granule-independent regulation.
Proteasome regulation of the chromodomain protein MRG-1 controls the balance between proliferative fate and differentiation in the C. elegans germ line.
Title: Proteasome regulation of the chromodomain protein MRG-1 controls the balance between proliferative fate and differentiation in the C. elegans germ line.
MRG-1 is critical for genomic integrity by promoting meiotic DNA double strand breaks repair and synapsis progression in meiosis.
Title: MRG-1 is required for genomic integrity in Caenorhabditis elegans germ cells.
evidence for presynaptic chromosome pairing activity intrinsic to non-pairing center regions, which is facilitated by a conserved chromodomain protein, MRG-1
Title: The chromodomain protein MRG-1 facilitates SC-independent homologous pairing during meiosis in Caenorhabditis elegans.
Here we demonstrate the importance of mrg-1 in development and reproduction in C. elegans and discuss its potential to impact the aging process.
Title: Functional analysis of MRG-1: the ortholog of human MRG15 in Caenorhabditis elegans.
MRG-1 is required to maintain repression in the maternal germ line of transgenes on extrachromosomal arrays, and of several X-linked genes previously shown to depend on MES-4 for repression
Title: MRG-1, an autosome-associated protein, silences X-linked genes and protects germline immortality in Caenorhabditis elegans.
MRG-1 is required maternally to form normal primordial germ cells with the potential to start mitotic proliferation during post-embryonic development.
Title: MRG-1, a mortality factor-related chromodomain protein, is required maternally for primordial germ cells to initiate mitotic proliferation in C. elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Y37D8A.9 (e-PCR)
- UniSTS:319749

Y37D8A.10 (e-PCR)
- UniSTS:320642

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA repair	IEA Inferred from Electronic Annotation more info
involved_in chromatin organization	IEA Inferred from Electronic Annotation more info
involved_in chromosome attachment to the nuclear envelope	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chromosome organization involved in meiotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryo development ending in birth or egg hatching	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germ cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heterochromatin formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in meiotic cell cycle	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein localization to euchromatin	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of NuA4 histone acetyltransferase complex	IBA Inferred from Biological aspect of Ancestor more info
located_in autosome	IDA Inferred from Direct Assay more info	PubMed
located_in chromatin	IMP Inferred from Mutant Phenotype more info	PubMed
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in euchromatin	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Mortality factor related protein 1

NP_001122727.1

Confirmed by transcript evidence

NP_499675.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

12871029..12874656 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_067274.6 → NP_499675.1 Mortality factor related protein 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_499675.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9XWW2

Conserved Domains (2) summary

pfam05712
Location:125 → 314

MRG

cl28914
Location:19 → 63

CD_CSD; CHROMO (CHRromatin Organization Modifier) domains and chromo shadow domains
NM_001129255.6 → NP_001122727.1 Mortality factor related protein 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001122727.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A7DTF0, Q9XWW2

Conserved Domains (2) summary

pfam05712
Location:125 → 316

MRG

cl28914
Location:19 → 63

CD_CSD; CHROMO (CHRromatin Organization Modifier) domains and chromo shadow domains