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tsp-12 Tetraspanin-12 [ Caenorhabditis elegans ]

Gene ID: 177890, updated on 2-Nov-2024

Summary

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Official Symbol
tsp-12
Official Full Name
Tetraspanin-12
Primary source
WormBase:WBGene00006638
Locus tag
CELE_T14G10.6
See related
AllianceGenome:WB:WBGene00006638
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables protease binding activity. Involved in several processes, including nematode male tail tip morphogenesis; positive regulation of egg-laying behavior; and positive regulation of transforming growth factor beta receptor signaling pathway. Located in cytoplasmic vesicle membrane and plasma membrane. Is expressed in several structures, including M lineage cell; germ line; intestine; pharynx; and vulval precursor cell. Used to study cancer. Orthologous to human TSPAN14 (tetraspanin 14); TSPAN17 (tetraspanin 17); and TSPAN5 (tetraspanin 5). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See tsp-12 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
4
Sequence:
Chromosome: IV; NC_003282.8 (10149166..10150602, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene SH2 domain-containing protein Neighboring gene GPI transamidase component PIG-S Neighboring gene ncRNA Neighboring gene Coatomer subunit gamma;putative coatomer subunit gamma

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A conserved tetraspanin subfamily promotes Notch signaling in Caenorhabditis elegans and in human cells. Dunn CD, et al. Proc Natl Acad Sci U S A, 2010 Mar 30. PMID 20220101, Free PMC Article
  2. Two Paralogous Tetraspanins TSP-12 and TSP-14 Function with the ADAM10 Metalloprotease SUP-17 to Promote BMP Signaling in Caenorhabditis elegans. Wang L, et al. PLoS Genet, 2017 Jan. PMID 28068334, Free PMC Article
  3. The C. elegans TspanC8 tetraspanin TSP-14 exhibits isoform-specific localization and function. Liu Z, et al. PLoS Genet, 2022 Jan. PMID 35089916, Free PMC Article
  4. Tetraspanins TSP-12 and TSP-14 function redundantly to regulate the trafficking of the type II BMP receptor in Caenorhabditis elegans. Liu Z, et al. Proc Natl Acad Sci U S A, 2020 Feb 11. PMID 31988138, Free PMC Article
  5. Promotion of bone morphogenetic protein signaling by tetraspanins and glycosphingolipids. Liu Z, et al. PLoS Genet, 2015 May. PMID 25978409, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The C. elegans TspanC8 tetraspanin TSP-14 exhibits isoform-specific localization and function.
    Title: The C. elegans TspanC8 tetraspanin TSP-14 exhibits isoform-specific localization and function.
  2. TSP-12 and TSP-14 are required for the recycling of DAF-4/BMPRII.
    Title: Tetraspanins TSP-12 and TSP-14 function redundantly to regulate the trafficking of the type II BMP receptor in Caenorhabditis elegans.
  3. TSP-12 can bind to and promote the cell surface localization of SUP-17. TSP-12 and TSP-14 function redundantly to promote BMP signaling.
    Title: Two Paralogous Tetraspanins TSP-12 and TSP-14 Function with the ADAM10 Metalloprotease SUP-17 to Promote BMP Signaling in Caenorhabditis elegans.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables protease binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in nematode male tail tip morphogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of egg-laying behavior IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of embryonic development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of transforming growth factor beta receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of vulval development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in protein localization to plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of mesodermal cell fate specification IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic vesicle membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in early endosome membrane IEA
Inferred from Electronic Annotation
more info
  
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
located_in late endosome membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in recycling endosome membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Tetraspanin-12
NP_501853.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    10149166..10150602 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_069452.5 → NP_501853.1  Tetraspanin-12 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_501853.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q22495
    Conserved Domains (1) summary
    pfam00335
    Location:38 → 293
    Tetraspannin; Tetraspanin family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q22495.1

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