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tsp-12 Tetraspanin-12 [ Caenorhabditis elegans ]

Gene ID: 177890, updated on 2-Nov-2024

Summary

Official Symbol
tsp-12
Official Full Name
Tetraspanin-12
Primary source
WormBase:WBGene00006638
Locus tag
CELE_T14G10.6
See related
AllianceGenome:WB:WBGene00006638
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables protease binding activity. Involved in several processes, including nematode male tail tip morphogenesis; positive regulation of egg-laying behavior; and positive regulation of transforming growth factor beta receptor signaling pathway. Located in cytoplasmic vesicle membrane and plasma membrane. Is expressed in several structures, including M lineage cell; germ line; intestine; pharynx; and vulval precursor cell. Used to study cancer. Orthologous to human TSPAN14 (tetraspanin 14); TSPAN17 (tetraspanin 17); and TSPAN5 (tetraspanin 5). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

See tsp-12 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
4
Sequence:
Chromosome: IV; NC_003282.8 (10149166..10150602, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene SH2 domain-containing protein Neighboring gene GPI transamidase component PIG-S Neighboring gene ncRNA Neighboring gene Coatomer subunit gamma;putative coatomer subunit gamma

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables protease binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasmic vesicle membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in early endosome membrane IEA
Inferred from Electronic Annotation
more info
 
located_in endosome IEA
Inferred from Electronic Annotation
more info
 
located_in late endosome membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in recycling endosome membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
Tetraspanin-12
NP_501853.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    10149166..10150602 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_069452.5NP_501853.1  Tetraspanin-12 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_501853.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q22495
    Conserved Domains (1) summary
    pfam00335
    Location:38293
    Tetraspannin; Tetraspanin family