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unc-23 BAG domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 179272, updated on 18-Sep-2024

Summary

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Official Symbol
unc-23
Official Full Name
BAG domain-containing protein
Primary source
WormBase:WBGene00006760
Locus tag
CELE_H14N18.1
See related
AllianceGenome:WB:WBGene00006760
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables heat shock protein binding activity. Involved in muscle attachment. Located in M band; nucleolus; and striated muscle dense body. Is expressed in several structures, including excretory canal; hypodermis; muscle cell; neurons; and pharynx. Orthologous to human BAG2 (BAG cochaperone 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See unc-23 in Genome Data Viewer
Location:
chromosome: V
Exon count:
5
Sequence:
Chromosome: V; NC_003283.11 (8936359..8939684)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene DUF2726 domain-containing protein Neighboring gene ncRNA Neighboring gene Atrophin-1 multi-domain protein;DUF148 domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Analysis of the effects of turning bias on chemotaxis in C. elegans. Pierce-Shimomura JT, et al. J Exp Biol, 2005 Dec. PMID 16326954
  2. The C. elegans UNC-23 protein, a member of the BCL-2-associated athanogene (BAG) family of chaperone regulators, interacts with HSP-1 to regulate cell attachment and maintain hypodermal integrity. Rahmani P, et al. Worm, 2015 Apr-Jun. PMID 26435886, Free PMC Article
  3. Chaperone complex BAG2-HSC70 regulates localization of Caenorhabditis elegans leucine-rich repeat kinase LRK-1 to the Golgi. Fukuzono T, et al. Genes Cells, 2016 Apr. PMID 26853528
  4. Chemotaxis by the nematode Caenorhabditis elegans: identification of attractants and analysis of the response by use of mutants. Ward S. Proc Natl Acad Sci U S A, 1973 Mar. PMID 4351805, Free PMC Article
  5. head-bent resistant Hsc70 variants show reduced Hsp40 affinity and altered protein folding activity. Papsdorf K, et al. Sci Rep, 2019 Aug 16. PMID 31420580, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Epithelial UNC-23 limits mechanical stress to maintain glia-neuron architecture in C. elegans.
    Title: Epithelial UNC-23 limits mechanical stress to maintain glia-neuron architecture in C. elegans.
  2. Study investigated the role of UNC-23 and HSP-1 on LRK-1 function in C. elegans; results suggest that the UNC-23-HSP-1 chaperone complex regulates LRK-1 localization to the Golgi apparatus and consequently determines the polarized sorting of synaptic vesicle proteins to the axons.
    Title: Chaperone complex BAG2-HSC70 regulates localization of Caenorhabditis elegans leucine-rich repeat kinase LRK-1 to the Golgi.
  3. Data indicate that UNC-23 protein interacts with molecular chaperone Hsc70, whose uncoupling from DNJ-13 protein cures the muscular phenotype.
    Title: The balanced regulation of Hsc70 by DNJ-13 and UNC-23 is required for muscle functionality.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATPase activator activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables adenyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables adenyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
  
enables heat shock protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-folding chaperone binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_positive_effect muscle attachment IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein stabilization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in M band IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in striated muscle dense body IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
BAG domain-containing protein
NP_001380002.1
  • Confirmed by transcript evidence
NP_505307.1
  • Confirmed by transcript evidence
NP_872142.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    8936359..8939684
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_072906.7 → NP_505307.1  BAG domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_505307.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O61980
    Conserved Domains (2) summary
    smart00264
    Location:370 → 450
    BAG; BAG domains, present in regulator of Hsp70 proteins
    TIGR02168
    Location:275 → 452
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  2. NM_001392570.1 → NP_001380002.1  BAG domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q5TKA9
    Conserved Domains (2) summary
    smart00264
    Location:369 → 449
    BAG; BAG domains, present in regulator of Hsp70 proteins
    TIGR02168
    Location:274 → 451
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  3. NM_182342.6 → NP_872142.1  BAG domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_872142.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q86S24
    Conserved Domains (2) summary
    smart00264
    Location:311 → 391
    BAG; BAG domains, present in regulator of Hsp70 proteins
    TIGR02168
    Location:216 → 393
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
Nucleotide Protein
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