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egl-3 Neuroendocrine convertase 2 [ Caenorhabditis elegans ]

Gene ID: 179412, updated on 2-Nov-2024

Summary

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Official Symbol
egl-3
Official Full Name
Neuroendocrine convertase 2
Primary source
WormBase:WBGene00001172
Locus tag
CELE_C51E3.7
See related
AllianceGenome:WB:WBGene00001172
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables FBXO family protein binding activity and serine-type endopeptidase activity. Involved in several processes, including modulation of chemical synaptic transmission; positive regulation of behavior; and protein processing. Located in axon. Is expressed in several structures, including intestine; nervous system; pharynx; tail; and uv1. Used to study alcohol use disorder. Human ortholog(s) of this gene implicated in myocardial infarction and type 2 diabetes mellitus. Orthologous to human PCSK2 (proprotein convertase subtilisin/kexin type 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See egl-3 in Genome Data Viewer
Location:
chromosome: V
Exon count:
8
Sequence:
Chromosome: V; NC_003283.11 (10169177..10173753, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein Neighboring gene DUF3149 domain-containing protein Neighboring gene Solute carrier family 23 member 2 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. WormTensor: a clustering method for time-series whole-brain activity data from C. elegans. Tsuyuzaki K, et al. BMC Bioinformatics, 2023 Jun 16. PMID 37328814, Free PMC Article
  2. Characterization of a key neuropeptide processing enzyme in C. elegans by mass spectrometry. Husson SJ, et al. Commun Agric Appl Biol Sci, 2006. PMID 17191499
  3. AWC thermosensory neuron interferes with information processing in a compact circuit regulating temperature-evoked posture dynamics in the nematode Caenorhabditis elegans. Kano A, et al. Neurosci Res, 2023 Mar. PMID 36336147
  4. Hypoxia induces food leaving in C. elegans. Pu L, et al. MicroPubl Biol, 2023. PMID 37033703, Free PMC Article
  5. Isolation and in situ localization of a cDNA encoding a Kex2-like prohormone convertase in the nematode Caenorhabditis elegans. Gómez-Saladín E, et al. Cell Mol Neurobiol, 1994 Feb. PMID 7954663

See all (70) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Our data has shown that thermal avoidance behavior of egl-3 and egl-21 mutants was significantly hampered compared to WT(N2) C. elegans.
    Title: EGL-3 and EGL-21 are required to trigger nocifensive response of Caenorhabditis elegans to noxious heat.
  2. Role of PC2/EGL-3 in the processing of FMRFamide-like peptide (FLP) precursors and neuropeptide-like protein (NLP) precursors in nematodes.
    Title: Defective processing of neuropeptide precursors in Caenorhabditis elegans lacking proprotein convertase 2 (KPC-2/EGL-3): mutant analysis by mass spectrometry.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables FBXO family protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables serine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables serine-type endopeptidase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables serine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in arg-arg specific dibasic protein processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in determination of adult lifespan IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in dibasic protein processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in insulin processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in larval feeding behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of dauer entry IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of dense core granule transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of turning behavior involved in mating IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuromuscular synaptic transmission IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in neuropeptide processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in peptide hormone processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of acetylcholine secretion, neurotransmission IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of acetylcholine secretion, neurotransmission IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of backward locomotion IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of digestive system process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of egg-laying behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of forward locomotion IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of forward locomotion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of lipid localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of locomotion involved in locomotory behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of synaptic assembly at neuromuscular junction IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of backward locomotion IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of eating behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of locomotion involved in locomotory behavior IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of locomotion involved in locomotory behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of muscle contraction IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of muscle contraction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of neuromuscular synaptic transmission IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of synaptic assembly at neuromuscular junction IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in response to mechanical stimulus IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in response to mechanical stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to serotonin IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in axon IDA
Inferred from Direct Assay
more info
 PubMed 
located_in axon IEA
Inferred from Electronic Annotation
more info
  
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in synapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Neuroendocrine convertase 2
NP_001023732.1
  • Confirmed by transcript evidence
NP_001256192.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    10169177..10173753 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001028561.4 → NP_001023732.1  Neuroendocrine convertase 2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001023732.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    E9P883, G5ECN9, Q18772
    Conserved Domains (3) summary
    cd04059
    Location:128 → 423
    Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
    pfam01483
    Location:532 → 619
    P_proprotein; Proprotein convertase P-domain
    pfam16470
    Location:29 → 107
    S8_pro-domain; Peptidase S8 pro-domain

  2. NM_001269263.3 → NP_001256192.1  Neuroendocrine convertase 2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001256192.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G5ECN9
    Conserved Domains (3) summary
    cd04059
    Location:3 → 298
    Peptidases_S8_Protein_convertases_Kexins_Furin-like; Peptidase S8 family domain in Protein convertases
    pfam00082
    Location:40 → 302
    Peptidase_S8; Subtilase family
    pfam01483
    Location:407 → 494
    P_proprotein; Proprotein convertase P-domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
G5ECN9.1

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