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ape-1 Apoptotic enhancer 1 protein [ Caenorhabditis elegans ]

Gene ID: 179601, updated on 12-Jun-2024

Summary

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Gene symbol
ape-1
Gene description
Apoptotic enhancer 1 protein
Locus tag
CELE_F46F3.4
See related
AllianceGenome:WB:WBGene00000146
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables p53 binding activity. Involved in negative regulation of apoptotic process. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Is expressed in several structures, including pharyngeal-intestinal valve; somatic nervous system; and spermatheca. Orthologous to several human genes including PPP1R13B (protein phosphatase 1 regulatory subunit 13B) and TP53BP2 (tumor protein p53 binding protein 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See ape-1 in Genome Data Viewer
Location:
chromosome: V
Exon count:
8
Sequence:
Chromosome: V; NC_003283.11 (11675938..11685274)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene Major facilitator superfamily (MFS) profile domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. iASPP oncoprotein is a key inhibitor of p53 conserved from worm to human. Bergamaschi D, et al. Nat Genet, 2003 Feb. PMID 12524540
  2. Assessment of stress-related gene expression in the heavy metal-exposed nematode Caenorhabditis elegans: a potential biomarker for metal-induced toxicity monitoring and environmental risk assessment. Roh JY, et al. Environ Toxicol Chem, 2006 Nov. PMID 17089718
  3. Signaling pathways of the ING proteins in apoptosis. Shah S, et al. Curr Drug Targets, 2009 May. PMID 19442111
  4. Conserved genes act as modifiers of invertebrate SMN loss of function defects. Dimitriadi M, et al. PLoS Genet, 2010 Oct 28. PMID 21124729, Free PMC Article
  5. DNA repair. O'Neil N, et al. WormBook, 2006 Jan 13. PMID 18050489, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables p53 binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables p53 binding IEA
Inferred from Electronic Annotation
more info
  
enables p53 binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of apoptotic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Apoptotic enhancer 1 protein
NP_001256353.1
  • Confirmed by transcript evidence
NP_001256354.1
  • Confirmed by transcript evidence
NP_001256355.1
  • Confirmed by transcript evidence
NP_001256356.1
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    11675938..11685274
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001269424.2 → NP_001256353.1  Apoptotic enhancer 1 protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001256353.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    E0AHC9, E0AHD0, E0AHD1, Q9XVN3
    Conserved Domains (5) summary
    smart00326
    Location:687 → 742
    SH3; Src homology 3 domains
    cd00204
    Location:578 → 674
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam10231
    Location:154 → 225
    DUF2315; uncharacterized conserved protein (DUF2315)
    pfam13637
    Location:588 → 639
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:585 → 616
    ANK; ANK repeat [structural motif]

  2. NM_001269425.4 → NP_001256354.1  Apoptotic enhancer 1 protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001256354.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E0AHC9
    Conserved Domains (5) summary
    smart00326
    Location:623 → 678
    SH3; Src homology 3 domains
    cd00204
    Location:514 → 610
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam10231
    Location:90 → 161
    DUF2315; uncharacterized conserved protein (DUF2315)
    pfam13637
    Location:524 → 575
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:521 → 552
    ANK; ANK repeat [structural motif]

  3. NM_001269426.3 → NP_001256355.1  Apoptotic enhancer 1 protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001256355.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E0AHD0
    Conserved Domains (4) summary
    smart00326
    Location:351 → 406
    SH3; Src homology 3 domains
    cd00204
    Location:242 → 338
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam13637
    Location:252 → 303
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:249 → 280
    ANK; ANK repeat [structural motif]

  4. NM_001269427.3 → NP_001256356.1  Apoptotic enhancer 1 protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001256356.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E0AHD1
    Conserved Domains (4) summary
    smart00326
    Location:259 → 314
    SH3; Src homology 3 domains
    cd00204
    Location:150 → 246
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam13637
    Location:160 → 211
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:157 → 188
    ANK; ANK repeat [structural motif]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9XVN3.1

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